2015年
Association between DNA methylation of the BDNF promoter region and clinical presentation in Alzheimer's disease
Dementia and Geriatric Cognitive Disorders Extra
- 巻
- 5
- 号
- 1
- 開始ページ
- 64
- 終了ページ
- 73
- 記述言語
- 掲載種別
- 研究論文(学術雑誌)
- DOI
- 10.1159/000375367
© 2015 S. Karger AG, Basel. Background/Aims: In the present study, we examined whether DNA methylation of the brain-derived neurotrophic factor (BDNF) promoter is associated with the manifestation and clinical presentation of Alzheimer's disease (AD). Methods: Of 20 patients with AD and 20 age-matched normal controls (NCs), the DNA methylation of the BDNF promoter (measured using peripheral blood samples) was completely analyzed in 12 patients with AD and 6 NCs. The resulting methylation levels were compared statistically. Next, we investigated the correlation between the DNA methylation levels and the clinical presentation of AD. Results: The total methylation ratio (in %) of the 20 CpG sites was significantly higher in the AD patients (5.08 ± 5.52%) than in the NCs (2.09 ± 0.81%; p < 0.05). Of the 20 CpG sites, the methylation level at the CpG4 site was significantly higher in the AD subjects than in the NCs (p < 0.05). Moreover, the methylation level was significantly and negatively correlated with some neuropsychological test subscores (registration, recall, and prehension behavior scores; p < 0.05). Conclusion: These results suggest that the DNA methylation of the BDNF promoter may significantly influence the manifestation of AD and might be associated with its neurocognitive presentation.
- リンク情報
- ID情報
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- DOI : 10.1159/000375367
- eISSN : 1664-5464
- PubMed ID : 25873928
- SCOPUS ID : 84931401930