2012年9月
Primary cilia and graded Sonic Hedgehog signaling
WILEY INTERDISCIPLINARY REVIEWS-DEVELOPMENTAL BIOLOGY
- ,
- 巻
- 1
- 号
- 5
- 開始ページ
- 753
- 終了ページ
- 772
- 記述言語
- 英語
- 掲載種別
- 研究論文(学術雑誌)
- DOI
- 10.1002/wdev.43
- 出版者・発行元
- WILEY-BLACKWELL
Cilia are evolutionary-conserved microtubule-containing organelles protruding from the surface of cells. They are classified into two types-primary and motile cilia. Primary cilia are nearly ubiquitous, at least in vertebrate cells, and it has become apparent that they play an essential role in the intracellular transduction of a range of stimuli. Most notable among these is Sonic Hedgehog. In this article we briefly summarize the structure and biogenesis of primary cilia. We discuss the evidence implicating cilia in the transduction of extrinsic signals. We focus on the involvement and molecular mechanism of cilia in signaling by Sonic Hedgehog in embryonic tissues, specifically the neural tube, and we discuss how cilia play an active role in the interpretation of gradients of Sonic Hedgehog (Shh) signaling. (C) 2012 Wiley Periodicals, Inc.
- リンク情報
- ID情報
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- DOI : 10.1002/wdev.43
- ISSN : 1759-7684
- eISSN : 1759-7692
- PubMed ID : 23799571
- Web of Science ID : WOS:000321263100010