2018年5月5日
High expression of A-type lamin in the leading front is required for Drosophila thorax closure
Biochemical and Biophysical Research Communications
- ,
- ,
- ,
- 巻
- 499
- 号
- 2
- 開始ページ
- 209
- 終了ページ
- 214
- 記述言語
- 英語
- 掲載種別
- 研究論文(学術雑誌)
- DOI
- 10.1016/j.bbrc.2018.03.128
- 出版者・発行元
- Elsevier B.V.
Tissue closure involves the coordinated unidirectional movement of a group of cells without loss of cell–cell contact. However, the molecular mechanisms controlling the tissue closure are not fully understood. Here, we demonstrate that Lamin C, the sole A-type lamin in Drosophila, contributes to the process of thorax closure in pupa. High expression of Lamin C was observed at the leading front of the migrating wing imaginal discs. Live imaging analysis revealed that knockdown of Lamin C in the thorax region affected the coordinated movement of the leading front, resulting in incomplete tissue fusion required for formation of the adult thorax. The closure defect due to knockdown of Lamin C correlated with insufficient accumulation of F-actin at the front. Our study indicates a link between A-type lamin and the cell migration behavior during tissue closure.
- ID情報
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- DOI : 10.1016/j.bbrc.2018.03.128
- ISSN : 1090-2104
- ISSN : 0006-291X
- ORCIDのPut Code : 42861494
- SCOPUS ID : 85044297866