1999年10月
Differential roles of TLR2 and TLR4 in recognition of gram-negative and gram-positive bacterial cell wall components
Immunity
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- 巻
- 11
- 号
- 4
- 開始ページ
- 443
- 終了ページ
- 451
- 記述言語
- 英語
- 掲載種別
- 研究論文(学術雑誌)
- DOI
- 10.1016/S1074-7613(00)80119-3
- 出版者・発行元
- CELL PRESS
Toll-like receptor (TLR) 2 and TLR4 are implicated in the recognition of various bacterial cell wall components, such as lipopolysaccharide (LPS). To investigate in vivo roles of TLR2, we generated TLR2-deficient mice. In contrast to LPS unresponsiveness in TLR4-deficient mice, TLR2-deficient mice responded to LPS to the same extent as wild-type mice. TLR2-deficient macrophages were hyporesponsive to several Gram-positive bacterial cell walls as well as Staphylococcus aureus peptidoglycan. TLR4-deficient macrophages lacked the response to Gram-positive lipoteichoic acids. These results demonstrate that TLR2 and TLR4 recognize different bacterial cell wall components in vivo and TLR2 plays a major role in Gram-positive bacterial recognition.
- リンク情報
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- DOI
- https://doi.org/10.1016/S1074-7613(00)80119-3
- PubMed
- https://www.ncbi.nlm.nih.gov/pubmed/10549626
- Web of Science
- https://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=JSTA_CEL&SrcApp=J_Gate_JST&DestLinkType=FullRecord&KeyUT=WOS:000083343100006&DestApp=WOS_CPL
- Scopus
- https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=0033213590&origin=inward 本文へのリンクあり
- Scopus Citedby
- https://www.scopus.com/inward/citedby.uri?partnerID=HzOxMe3b&scp=0033213590&origin=inward
- ID情報
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- DOI : 10.1016/S1074-7613(00)80119-3
- ISSN : 1074-7613
- PubMed ID : 10549626
- SCOPUS ID : 0033213590
- Web of Science ID : WOS:000083343100006