2015年3月
Design of a CO-releasing Extracellular Scaffold Using in Vivo Protein Crystals
CHEMISTRY LETTERS
- 巻
- 44
- 号
- 3
- 開始ページ
- 342
- 終了ページ
- 344
- 記述言語
- 英語
- 掲載種別
- 研究論文(学術雑誌)
- DOI
- 10.1246/cl.141035
- 出版者・発行元
- CHEMICAL SOC JAPAN
A crystalline protein assembly of cypovirus polyhedra was engineered to develop a carbon monoxide (CO) releasing extracellular scaffold by immobilizing ruthenium carbonyls. The molecular design includes introduction of a hexahistidine tag to the C-terminus and provides immobilization of about 2-fold more Ru carbonyls per protein monomer and effectively releases three times more CO for activation of nuclear factor kappa B (NF-kappa B) in living cells relative to wild-type polyhedra with Ru carbonyls.
- リンク情報
- ID情報
-
- DOI : 10.1246/cl.141035
- ISSN : 0366-7022
- eISSN : 1348-0715
- Web of Science ID : WOS:000350526600037