2009年
Effect of Food Restriction on Adipose Tissue in Spontaneously Diabetic Torii Fatty Rats
EXPERIMENTAL DIABETES RESEARCH
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- 巻
- 2009
- 号
- ID715057
- 記述言語
- 英語
- 掲載種別
- 研究論文(学術雑誌)
- DOI
- 10.1155/2009/715057
- 出版者・発行元
- HINDAWI PUBLISHING CORPORATION
Spontaneously Diabetic Torii-fa/fa (SDT fatty) rat is a new model of obese type 2 diabetes. SDT fatty rat exhibits obesity associated with hyperphagia. In this study, SDT fatty rats were subjected to pair-feeding with SDT-+/+ (SDT) rats from 6 to 22 weeks of age. The ratio of visceral fat weight to subcutaneous fat weight (V/S) decreased at 12 weeks of age in the pair-feeding rats. The intraperitoneal fat weight such as epididymal and retroperitoneal fat weight decreased, whereas mesenteric fat weight had no change. Cell size of the epididymal fat in the pair-feeding rats tended to decrease. Glucose oxidation level in epididymal fat in the pair-feeding rats at 12 weeks of age was recovered to a similar level with that in SDT rats. These results indicated that SDT fatty rat is a useful model to evaluate the functional or the morphological features in adipose tissue and develop a novel drug for antiobesity. Copyright (C) 2009 Hisayo Morinaga et al.
- リンク情報
- ID情報
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- DOI : 10.1155/2009/715057
- ISSN : 1687-5214
- Web of Science ID : WOS:000270535100001