J-GLOBAL         Last updated: Jul 7, 2019 at 13:41
Osaka University
Graduate School of Science Department of Chemistry
Job title

Research Areas


Academic & Professional Experience

Suntory Institute for Bioorganic Research,
      Research Staff
Tohoku University, Research Associate
The University of Tokyo, Associate Professor
- Osaka University, Professor

Published Papers

Hayashi T, Tsuchikawa H, Umegawa Y, Murata M
Bioorganic & medicinal chemistry   27(8) 1677-1682   Apr 2019   [Refereed]
Möuts A, Yamamoto T, Nyholm TKM, Murata M, Slotte JP
Biophysical journal   116(8) 1507-1515   Apr 2019   [Refereed]
Tomoya Yamamoto, Yuichi Umegawa, Masaki Yamagami, Taiga Suzuki, Hiroshi Tsuchikawa, Shinya Hanashima, Nobuaki Matsumori, Michio Murata
Biochemistry      Apr 2019   [Refereed]
Yano Y, Hanashima S, Yasuda T, Tsuchikawa H, Matsumori N, Kinoshita M, Al Sazzad MA, Slotte JP, Murata M
Biophysical journal   115(8) 1530-1540   Oct 2018   [Refereed]
Masanao Kinoshita, Kenichi G.N. Suzuki, Michio Murata, Michio Murata, Nobuaki Matsumori
Chemistry and Physics of Lipids   215 84-95   Sep 2018   [Refereed]
© 2018 Elsevier B.V. Sphingomyelin (SM)-rich membrane nano-domains, called lipid rafts, have attracted the interest of researchers due to their potential involvement in the formation of signaling platform. Although there are many studies on lipid ...
Soon-Lim Chong, Arshia Hematpoor, Hazrina Hazni, Mohd Sofian-Azirun, Marc Litaudon, Unang Supratman, Michio Murata, Khalijah Awang
Phytochemistry Letters   30 69-73   Apr 2019   [Refereed]
Cornelio K, Espiritu RA, Hanashima S, Todokoro Y, Malabed R, Kinoshita M, Matsumori N, Murata M, Nishimura S, Kakeya H, Yoshida M, Matsunaga S
Biochimica et biophysica acta. Biomembranes   1861(1) 228-235   Jan 2019   [Refereed]
Yasuda T, Slotte JP, Murata M
Langmuir : the ACS journal of surfaces and colloids   34(44) 13426-13437   Nov 2018   [Refereed]
Futoshi Hasegawa, Yoshifumi Yasukawa, Kazushi Kawamura, Hiroshi Tsuchikawa, Michio Murata
Asian Journal of Organic Chemistry   7 1648-1653   Aug 2018
© 2018 Wiley-VCH Verlag GmbH & Co. KGaA, Weinheim We achieved a highly diastereoselective synthesis of 1-aryl-6-aminouracils, which are C−N atropisomeric compounds, through the combined use of a chiral auxiliary and a chiral base under mild cond...
Yuma Wakamiya, Makoto Ebine, Mariko Murayama, Hiroyuki Omizu, Nobuaki Matsumori, Michio Murata, Tohru Oishi
Angewandte Chemie - International Edition   57(21) 6060-6064   May 2018   [Refereed]
© 2018 Wiley-VCH Verlag GmbH & Co. KGaA, Weinheim Amphidinol 3 (AM3) is a marine natural product produced by the dinoflagellate Amphidinium klebsii. Although the absolute configuration of AM3 was determined in 1999 by extensive NMR analysis and ...
Yoshifumi Yasukawa, Hiroshi Tsuchikawa, Yasuto Todokoro, Michio Murata
Asian Journal of Organic Chemistry   7 1101-1106   Jun 2018
© 2018 Wiley-VCH Verlag GmbH & Co. KGaA, Weinheim The cisoid-selective construction of a tricyclic bisspiroacetal framework was demonstrated using MgBr2as a cisoid stabilizer through chelation of the oxygen atoms of lateral acetal rings in the c...
Tomohiro Watanabe, Hajime Shibata, Makoto Ebine, Hiroshi Tsuchikawa, Nobuaki Matsumori, Michio Murata, Manabu Yoshida, Masaaki Morisawa, Shu Lin, Kosei Yamauchi, Ken Sakai, Tohru Oishi
Journal of Natural Products   81(4) 985-997   Apr 2018   [Refereed]
© 2018 American Chemical Society and American Society of Pharmacognosy. For the complete structure elucidation of an endogenous sperm-activating and -attracting factor isolated from eggs of the ascidian Ascidia sydneiensis (Assydn-SAAF), its two p...
Sébastien Lethu, Sébastien Lethu, Hikaru Ano, Michio Murata, Shigeru Matsuoka, Shigeru Matsuoka
European Journal of Organic Chemistry   2018 235-239   Jan 2018
© 2018 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim We report an efficient method for the synthesis of a chiral C-CHD-CHD-C unit in threo form, which enables the asymmetric conformational analysis of straight alkyl chains. The vicinal dideuterated...
Masanao Kinoshita, Masanao Kinoshita, Masanao Kinoshita, Hikaru Ano, Hikaru Ano, Michio Murata, Michio Murata, Michio Murata, Kenta Shigetomi, Junichi Ikenouchi, Nobuaki Matsumori, Nobuaki Matsumori, Nobuaki Matsumori
Scientific Reports   7    Dec 2017
© 2017 The Author(s). Imaging the distribution of sphingomyelin (SM) in membranes is an important issue in lipid-raft research. Recently we developed novel fluorescent SM analogs that exhibit partition and dynamic behaviors similar to native SM, a...
Raymond Malabed, Raymond Malabed, Shinya Hanashima, Michio Murata, Michio Murata, Kaori Sakurai
Biochimica et Biophysica Acta - Biomembranes   1859 2516-2525   Dec 2017
© 2017 Elsevier B.V. OSW-1 is a structurally unique steroidal saponin isolated from the bulbs of Ornithogalum saundersiae, and has exhibited highly potent and selective cytotoxicity in tumor cell lines. This study aimed to investigate the molecula...
Masayuki Satake, Kimberly Cornelio, Kimberly Cornelio, Shinya Hanashima, Raymond Malabed, Michio Murata, Michio Murata, Nobuaki Matsumori, Huiping Zhang, Fumiaki Hayashi, Shoko Mori, Jong Souk Kim, Chang Hoon Kim, Jong Soo Lee
Journal of Natural Products   80 2883-2888   Nov 2017
© 2017 The American Chemical Society and American Society of Pharmacognosy. Amphidinols are polyketide metabolites produced by marine dinoflagellates and are chiefly composed of a long linear chain with polyol groups and polyolefins. Two new homol...
Hiroshi Tsuchikawa, Kou Minamino, Sho Hayashi, Michio Murata, Michio Murata
Asian Journal of Organic Chemistry   6 1322-1327   Sep 2017
© 2017 Wiley-VCH Verlag GmbH & Co. KGaA, Weinheim A functionalized bicyclic lactam that was used as a key intermediate in an efficient synthesis of the pharmacophore of potent marine toxin spirolide C was synthesized by using a highly selective ...
Minoru Kubo, Minoru Kubo, Eriko Nango, Eriko Nango, Kensuke Tono, Tetsunari Kimura, Tetsunari Kimura, Shigeki Owada, Changyong Song, Changyong Song, Fumitaka Mafuné, Ken Miyajima, Yoshihiro Takeda, Jun Ya Kohno, Naoya Miyauchi, Takanori Nakane, Tomoyuki Tanaka, Takashi Nomura, Jan Davidsson, Rie Tanaka, Michio Murata, Takashi Kameshima, Takaki Hatsui, Yasumasa Joti, Richard Neutze, Makina Yabashi, So Iwata, So Iwata
Journal of Synchrotron Radiation   24 1086-1091   Sep 2017
© Minoru Kubo et al. 2017. X-ray free-electron lasers (XFELs) have opened new opportunities for time-resolved X-ray crystallography. Here a nanosecond optical-pump XFEL-probe device developed for time-resolved serial femtosecond crystallography (T...
J. Peter Slotte, Tomokazu Yasuda, Tomokazu Yasuda, Oskar Engberg, Md Abdullah Al Sazzad, Victor Hautala, Thomas K.M. Nyholm, Michio Murata, Michio Murata
Biophysical Journal   112 1673-1681   Apr 2017
© 2017 Biophysical Society Using differential scanning calorimetry and lifetime analysis of trans-parinaric acid fluorescence, we have examined how cholesterol and cholesteryl phosphocholine (CholPC) affect gel-phase properties of palmitoyl cerami...
Masanao Kinoshita, Masanao Kinoshita, Masanao Kinoshita, Kenichi G.N. Suzuki, Kenichi G.N. Suzuki, Nobuaki Matsumori, Nobuaki Matsumori, Nobuaki Matsumori, Nobuaki Matsumori, Misa Takada, Hikaru Ano, Hikaru Ano, Kenichi Morigaki, Mitsuhiro Abe, Asami Makino, Toshihide Kobayashi, Koichiro M. Hirosawa, Takahiro K. Fujiwara, Akihiro Kusumi, Akihiro Kusumi, Akihiro Kusumi, Michio Murata, Michio Murata, Michio Murata
Journal of Cell Biology   216 1183-1204   Apr 2017
© 2017 Kinoshita et al. Sphingomyelin (SM) has been proposed to form cholesterol-dependent raft domains and sphingolipid domains in the plasma membrane (PM). How SM contributes to the formation and function of these domains remains unknown, primar...


Yuichi Umegawa, Yuichi Umegawa, Yuichi Umegawa, Nobuaki Matsumori, Nobuaki Matsumori, Michio Murata, Michio Murata
Annual Reports on NMR Spectroscopy   94 41-72   Jan 2018
© 2018 Elsevier Ltd Interactional and structural analyses of lipids in hydrated biomembranes are at the frontier of membrane physics and biology. Recently, solid-state NMR has emerged as a frequently used technique for the investigation of biomemb...
Nobuaki Matsumori, Michio Murata, Michio Murata
Experimental Approaches of NMR Spectroscopy: Methodology and Application to Life Science and Materials Science   383-414   Nov 2017
© Springer Nature Singapore Pte Ltd. 2018. All rights reserved. In this chapter we overview two topics on NMR methodologies for small molecules, mostly natural products; one is about the solution NMR-based methods used for stereochemical determina...
Michio Murata, Michio Murata, Shigeru Sugiyama, Shigeru Sugiyama, Shigeru Matsuoka, Nobuaki Matsumori, Nobuaki Matsumori
Chemical Record   15 675-690   Aug 2015
© 2015 The Chemical Society of Japan & Wiley-VCH Verlag GmbH & Co. KGaA, Weinheim. Determining the bioactive structure of membrane lipids is a new concept, which aims to examine the functions of lipids with respect to their three-dimensional s...
Minoru Isobe, Michio Murata, Shinya Hanashima, Atsushi Nishida, Teck Peng Loh, Noorsaadah Abd Rahman, Nopporn Thasana, Montakarn Chittchang
Chemistry - An Asian Journal   9 1689-1696   Jan 2014
Michio Murata, Yusuke Kasai, Yuichi Umegawa, Naohiro Matsushita, Hiroshi Tsuchikawa, Nobuaki Matsumori, Tohru Oishi
Pure and Applied Chemistry   81 1123-1129   Jul 2009
Amphotericin B (AmB) exerts its pharmacological effects by forming a barrel-stave assembly in fungal membranes. To examine the interaction between AmB and ergosterol or cholesterol,13C- and19F-labeled covalent conjugates were prepared and subjecte...
Design, synthesis, and biological evaluation of fluorinated analogs of salicylihalamide.
Maitotoxin-photoactive probe binds to membrane proteins in erythrocyte membrane.
Synthesis oh the JK ring fragments of yessotoxin and 42, 43, 44, 45, 46, 47, 55-heptanor-41-oxoyessotoxin
M. Murata, T. Oishi, M. Yoshida
Progress in molecular and subcellular biology.   42 203-220   Aug 2006
Structure elucidation studies on natural products are reviewed emphasizing extremely small sample amounts. Previous studies on insect pheromones, periplanones, and bean-originating kairomones, glycinoeclepins, are described briefly. Recent example...
Nobuaki Matsumori, Tohru Oishi, Michio Murata
Yuki Gosei Kagaku Kyokaishi/Journal of Synthetic Organic Chemistry   64 502-513   May 2006
Amphotericin B (AmB) is known to assemble together and form an ion channel across biomembranes. The selective toxicity is generally accounted for by its higher affinity for ergosterol than cholesterol. To better understand the ion-channel structur...
Synthesis of artificial ladder-shaped polyether containing a 6/7 cis-fused ring system
Heterocycles   70, 161-167    2006
Progress in Molecular and Subcellular Biology
Springer-Verlag      2006
Mycosamine orientation of amphotericin B controlling interaction with ergosterol: sterol-dependent activity
Journal of American Chemical Society   127    2005
Inhibition of maitotoxin-induced Ca2+ in flux in rat glioma C6 cells by brevetoxin and Syhthetic fragments of maitotoxin
Journal of Ncurochemistry   70 409   1998
Makoto Sasaki, Michio Murata
Yuki Gosei Kagaku Kyokaishi/Journal of Synthetic Organic Chemistry   55 535-546   Jan 1997
Maitotoxin (MTX, 1) is the most toxic and largest non-biopolymer known to date. The complete structural determination of MTX including the absolute configuration has been achieved recently. The relative configurations of the four acyclic portions ...
Michio Murata, Nobuaki Matsumori, Nobuaki Matsumori, Kazuo Tachibana
Nippon Kagaku Kaishi / Chemical Society of Japan - Chemistry and Industrial Chemistry Journal   749-757   Jan 1997
A new NMR methodology was devised for configurational assignments of acyclic structures in natural products or synthetic compounds. Conventional methods based on NOEs often suffer from the ambiguity in assigning the configurations of compounds wit...
Michio Murata, Takeshi Yasumoto
Yuki Gosei Kagaku Kyokaishi/Journal of Synthetic Organic Chemistry   53(3) 207-217   Jan 1995
Maitotoxin was first discovered as one of the causative toxins responsible for ciguatera, which is a form of seafood poisoning prevalent in coral reef area. The structure (1) has been elucidated to be a polyketide compound with a molecular weight ...
Structure elucidation of maitotoxin with molecular weight of 3422
53(3) 207   1995
Michio Murata, Masahiro Sasaki, Akihiro Yokoyama, Takeshi Yasumoto, Hideo Naoki, Takashi Iwashita, Shigeki Matsunaga
Journal of the American Chemical Society   115 2060-2062   Mar 1993
Takeshi Yasumoto, Michio Murata, Michio Murata
Chemical Reviews   93(5) 1897-1909   Jan 1993
Oxidation of the 27-hydroxyl group results in a marked decrease in the affinity of okadaic acid to protein phosphatases
Biochemical Journal   298,259    1993
Inhibitory effect of derivatives of okadaic acid on protein phosphatase ; a study on structure-affinity relationship
Biochemical Journal   284,539    1992
Gambieric acids, unprecedentedly potent anti-fungals isolated from cultures of a marine dinoflagellate ┣DBGambierdiscus toxicus(/)-┫DB
Journal of the American Chemical Society   114,1102    1992
Takeshi Yasumoto, Mari Yotsu, Amane Endo, Mi chio Murata, Hideo Naoki
Pure and Applied Chemistry   61 505-508   Jan 1989
Screening for tetrodotoxin among biota at low levels of the food chain led us to identification of bacteria as the primary source of the toxin. In parallel with the search for the biogenetic origin, we explored naturally occurring tetrodotoxin ana...
Hirota Fujiki, Masami Suganuma, Hiroko Suguri, Shigeru Yoshizawa, Kanji Takagi, Naoto Uda, Kazumasa Wakamatsu, Kiyoyuki Yamada, Michio Murata, Takeshi Yasumoto, Takashi Sugimura
Japanese Journal of Cancer Research   79 1089-1093   Jan 1988
Dinophysistoxin‐1, 35‐methylokadaic acid, is a causative agent of diarrhetic shellfish poisoning. The biological activities and tumor‐promoting activity of dinophysistoxin‐1 were studied together with those of okadaic acid and 7‐O‐palmitoyl okadai...


Structure of Amino Acid in Glycated Collagen
18O-Incorporation Experiment Using MS/MS
NMR-based Configuration Analysis for Acyclic Compounds
Bioactive Lipid Structures