Michio Murata

Profile Information

Affiliation: specially appointed professor, Institute for Protein Research, Osaka University

Degree: (BLANK)

J-GLOBAL ID: 200901090408829973
researchmap Member ID: 1000161603

External link: http://www.chem.sci.osaka-u.ac.jp/lab/murata/

Research Interests

Research Areas

Research History

Apr, 2024 - Present

Specially Apointed Professor, Osaka University
Apr, 1999 - Mar, 2024

Professor, Department of Chemistry, Graduate School of Science, Osaka University
2011 - 2017

Reserach Director, ERATO Lipid Active Structure Project, Japan Science and Technology Agency
1993 - 1999

Associate Professor,, Chemsitry Department, Graduate School of Science, The University of Tokyo
1985 - 1993

Reseach Associate, Faculty of Agriclture, Tohoku University

Papers

320

Protein-lipid acyl chain interactions: Depth-dependent changes of segmental mobility of phospholipid in contact with bacteriorhodopsin.

Yuichi Umegawa, Sho Kato, Sangjae Seo, Wataru Shinoda, Satoshi Kawatake, Shigeru Matsuoka, Michio Murata

Biophysical chemistry, 308 107204-107204, Feb 22, 2024
NMR Studies on the Structure and Functions of Small Biomolecules with Highly Flexible Conformation

Michio Murata, Yuichi Umegawa, Shinya Hanashima

Bulletin of the Chemical Society of Japan, 96(10) 1156-1168, Oct 15, 2023
Passive Translocation of Phospholipids in Asymmetric Model Membranes: Solid-State 1H NMR Characterization of Flip-Flop Kinetics Using Deuterated Sphingomyelin and Phosphatidylcholine.

Hirofumi Watanabe, Shinya Hanashima, Yo Yano, Tomokazu Yasuda, Michio Murata

Langmuir : the ACS journal of surfaces and colloids, Sep 20, 2023
Dynamic assembly and interaction of glycosphingolipids in cholesterol-containing model membranes

Shinya Hanashima, Mikito Nakano, Michio Murata

Pure and Applied Chemistry, Apr 28, 2023 Peer-reviewedInvited
Effect of the number of sugar units on the interaction between diosgenyl saponin and membrane lipids.

Joan Candice Ondevilla, Shinya Hanashima, Akane Mukogawa, Darcy Garza Miyazato, Yuichi Umegawa, Michio Murata

Biochimica et biophysica acta. Biomembranes, 1865(5) 184145-184145, Mar 11, 2023 Peer-reviewedLast authorCorresponding author
Combined effect of the head groups and alkyl chains of archaea lipids when interacting with bacteriorhodopsin.

Yuichi Umegawa, Satoshi Kawatake, Michio Murata, Shigeru Matsuoka

Biophysical chemistry, 294 106959-106959, Mar, 2023 Peer-reviewedInvited
A fluorescent probe of C24 fatty acid to report the deep interior of lipid bilayers

Yuichi Umegawa, Shiho Fukunaga, Tomokazu Yasuda, Michio Murata

Synlett, 2023
Molecular Dynamics of Glycolipids in Liposomes.

Tomokazu Yasuda, J Peter Slotte, Michio Murata, Shinya Hanashima

Methods in molecular biology (Clifton, N.J.), 2613 257-270, 2023
Behavior of Triterpenoid Saponin Ginsenoside Rh2 in Ordered and Disordered Phases in Model Membranes Consisting of Sphingomyelin, Phosphatidylcholine, and Cholesterol

Darcy Lacanilao Garza, Shinya Hanashima, Yuichi Umegawa, Michio Murata, Masanao Kinoshita, Nobuaki Matsumori, Peter Greimel

Langmuir, 38(34) 10478-10491, Aug 19, 2022 Peer-reviewedCorresponding author
LnDOTA ‐d ₈ , a versatile chemical‐shift thermometer for ² H solid‐state NMR

Yuichi Umegawa, Takeshi Shimonishi, Hiroshi Tsuchikawa, Michio Murata

Magnetic Resonance in Chemistry, 60(10) 1005-1013, Aug 17, 2022 Peer-reviewedLast author
Lipid chain-driven interaction of a lipidated Src-family kinase Lyn with the bilayer membrane.

Shinya Hanashima, Kanako Mito, Yuichi Umegawa, Michio Murata, Hironobu Hojo

Organic & biomolecular chemistry, 20(32) 6436-6444, Aug 17, 2022 Peer-reviewed
Experimental and theoretical investigations into the mechanism of interactions between membrane-bound fatty acids and their binding protein: A model system to investigate the behavior of lipid acyl chains in contact with proteins

Shigeru Sugiyama, Daisuke Matsuoka, Toshiaki Hara, Masashi Sonoyama, Shigeru Matsuoka, Michio Murata

Chemistry and Physics of Lipids, 247 105227-105227, Aug, 2022 Peer-reviewedCorresponding author
Amphotericin B assembles into seven-molecule ion channels: An NMR and molecular dynamics study.

Yuichi Umegawa, Tomoya Yamamoto, Mayank Dixit, Kosuke Funahashi, Sangjae Seo, Yasuo Nakagawa, Taiga Suzuki, Shigeru Matsuoka, Hiroshi Tsuchikawa, Shinya Hanashima …

Science advances, 8(24) eabo2658, Jun 17, 2022 Peer-reviewedCorresponding author
Molecular substructure of the liquid-ordered phase formed by sphingomyelin and cholesterol: sphingomyelin clusters forming nano-subdomains are a characteristic feature

Michio Murata, Nobuaki Matsumori, Masanao Kinoshita, Erwin London

Biophysical Reviews, 14(3) 655-678, Jun, 2022 Peer-reviewedLead authorCorresponding author
Depth-Dependent Segmental Melting of the Sphingomyelin Alkyl Chain in Lipid Bilayers.

Hiroshi Tsuchikawa, Mami Monji, Yuichi Umegawa, Tomokazu Yasuda, J Peter Slotte, Michio Murata

Langmuir : the ACS journal of surfaces and colloids, 38(18) 5515-5524, May 10, 2022 Peer-reviewedLast authorCorresponding author
Effect of cholesterol on the lactosylceramide domains in phospholipid bilayers.

Shinya Hanashima, Ryuji Ikeda, Yuki Matsubara, Tomokazu Yasuda, Hiroshi Tsuchikawa, J Peter Slotte, Michio Murata

Biophysical journal, 121(7) 1143-1155, Apr 5, 2022 Peer-reviewedLast authorCorresponding author
FRET detects lateral interaction between transmembrane domain of EGF receptor and ganglioside GM3 in lipid bilayers

Mikito Nakano, Shinya Hanashima, Toshiaki Hara, Kazuya Kabayama, Yuya Asahina, Hironobu Hojo, Naoko Komura, Hiromune Ando, Thomas K.M. Nyholm, J. Peter Slotte …

Biochimica et Biophysica Acta (BBA) - Biomembranes, 1863(8) 183623-183623, Aug, 2021 Peer-reviewedCorresponding author
Diosgenin-induced physicochemical effects on phospholipid bilayers in comparison with cholesterol

Joan Candice Ondevilla, Shinya Hanashima, Akane Mukogawa, Yuichi Umegawa, Michio Murata

Bioorganic & Medicinal Chemistry Letters, 36 127816-127816, Mar, 2021 Peer-reviewedLast authorCorresponding author
β-Glucosylation of cholesterol reduces sterol-sphingomyelin interactions

Shinya Hanashima, Nanami Fukuda, Raymond Malabed, Michio Murata, Msanao Kinoshita, Peter Greimel, Yoshio Hirabayashi

Biochimica et Biophysica Acta (BBA) - Biomembranes, 1863(2) 183496-183496, Feb, 2021 Peer-reviewedCorresponding author
Impact of Intrinsic and Extrinsic Factors on Cellular Sphingomyelin Imaging with Specific Reporter Proteins

Toshihide Kobayashi, Nario Tomishige, Takehiko Inaba, Asami Makino, Michio Murata, Akiko Yamaji-Hasegawa, Motohide Murate

Contact, 4 251525642110424-251525642110424, Jan, 2021 Peer-reviewed

Misc.

148

X-ray crystal structure analysis of MHC class I like molecule CD1d in complex with glycolipids

喜多俊介, 秋田穂, 日下裕規, TIAN Cong, 田所高志, 井貫晋輔, 新山真由美, 杉山成, 村田道雄, 藤本ゆかり …

日本蛋白質科学会年会プログラム・要旨集, 22nd (Web), 2022
Investigation of Inner Leaflet Lipids Influence on Sphingomyelin Domain

LIAO Chia-Hui, HANASHIMA Shinya, YASUDA Tomokazu, MURATA Michio

日本化学会春季年会講演予稿集(Web), 102nd, 2022
Elucidation of dynamic behavior of exosome membranes involved in intracellular uptake efficiency

YASUDA Tomokazu, HIROSAWA Koichiro M., SUZUKI Kenichi G.N., KABAYAMA Kazuya, MURATA Michio, HANASHIMA Shinya

日本化学会春季年会講演予稿集(Web), 102nd, 2022
Leaflet-specific quantification of choline lipids in the two layers of asymmetric vesicles

渡辺宏史, 花島慎弥, 安田智一, 村田道雄

日本化学会春季年会講演予稿集(Web), 102nd, 2022
Dynamic behavior of phosphatidylethanolamine as an inner leaflet lipid in biological model membranes

西直也, 安田智一, 花島慎弥, 村田道雄

日本化学会春季年会講演予稿集(Web), 102nd, 2022
Elucidation of dynamic behavior of Ceramide 1-phosphate in lipid bilayers in association with cytosolic phospholipase A₂ activation

植浦大貴, 中込まどか, 花島慎弥, 安田智一, 安田智一, 村田道雄

日本化学会春季年会講演予稿集(Web), 102nd, 2022
FRET detects lateral interaction between transmembrane domain of EGF receptor and ganglioside GM3 in lipid bilayers

Nakano Mikito, Hanashima Shinya, Hara Toshiaki, Hara Toshiaki, Kabayama Kazuya, Asahina Yuya, Hojo Hironobu, Komura Naoko, Komura Naoko, Ando Hiromune …

Biochimica et Biophysica Acta, 1863(8), 2021
Membrane Lipids Affect the Interplay between the Transmembrane Domain of the EGF Receptor and Ganglioside GM3-Thermodynamic Quantification of the Lateral Interaction using FRET

NAKANO Mikito, HANASHIMA Shinya, HARA Toshiaki, KABAYAMA Kazuya, KOMURA Naoko, ANDO Hiromune, NYHOLM Thomas K. M., SLOTTE Peter J., MURATA Michio

日本化学会春季年会講演予稿集(Web), 101st, 2021
Structural Basis for Membrane Receptor Activity of Ganglioside GM3 Regulated by Lipid-Lipid Interactions

SASAKI Katsuaki, HANASHIMA Shinya, UMEGAWA Yuichi, MURATA Michio

日本化学会春季年会講演予稿集(Web), 101st, 2021
Membrane interaction and disrupting activity of ginsenoside Rh2 to cholesterol and sphingomyelin-containing liposomes

GARZA Darcy, HANASHIMA Shinya, MURATA Michio

日本化学会春季年会講演予稿集(Web), 101st, 2021
Elucidation of inter-leaflet coupling in asymmetric membranes induced by very long chain sphingomyelin based on solid-state NMR

KEERATISAKULSITH Tanatchphong, UMEGAWA Yuichi, TSUCHIKAWA Hiroshi, HANASHIMA Shinya, MURATA Michio, SHINODA Wataru

日本化学会春季年会講演予稿集(Web), 101st, 2021
Natural products and membrane lipids interplay responsible for biological activities

村田道雄, 梅川雄一, 花島慎弥, 土川博史

日本農芸化学会大会講演要旨集(Web), 2021, 2021
Solid-State NMR Analysis of the GM3 Glycan Conformations Dependent on the Lipid Bilayer Composition

佐々木克聡, 梅川雄一, 村田道雄, 花島慎弥

日本糖質学会年会要旨集, 40th, 2021
Thermal stability analysis of lipid antigen presenting molecule, CD1d

秋田穂, 日下裕規, TIAN Cong, 田所高志, 井貫晋輔, 新山真由美, 杉山成, 村田道雄, 藤本ゆかり, 喜多俊介 …

日本分子生物学会年会プログラム・要旨集(Web), 44th, 2021
MHC classI様分子CD1dとアミド型α-GarCer複合体のX線結晶構造解析

秋田穂, 日下裕規, 田聡, 田所高志, 井貫晋輔, 新山真由美, 杉山成, 村田道雄, 藤本ゆかり, 喜多俊介 …

日本結晶学会年会講演要旨集, 2021, 2021
FRET analysis for the sphingolipid domains in model bilayer membranes using the fluorescent sphingolipid probes

友田千尋, 矢野陽, 花島慎弥, 河村奈緒子, 安藤弘宗, 村田道雄, LONDON Erwin

日本化学会春季年会講演予稿集(Web), 101st, 2021
Quantitative Analysis of Lipid Composition of L_o/L_d Phase in Phase-Separated Membrane Using Deuterium Solid-state NMR

山中彩菜, 花島慎弥, 井端悠貴, 梅川雄一, 村田道雄

日本化学会春季年会講演予稿集(Web), 101st, 2021
Cholesterol Distribution in The Inner and Outer Leaflets of Asymmetric Bilayer Membranes

渡辺宏史, 花島慎弥, 村田道雄

日本化学会春季年会講演予稿集(Web), 101st, 2021
Evaluation of membrane functions of polyunsaturated fatty acid-substituted phospholipids based on solid-state-NMR

大田英和, 梅川雄一, 花島慎弥, 土川博史, 村田道雄

日本化学会春季年会講演予稿集(Web), 101st, 2021
Evaluation of the Glycosylation Effect on the Interaction of Cholesteryl Glucoside with Membrane Lipids

花島慎弥, 福田奈那美, MALABED Raymond, 村田道雄, 木下祥尚, GREIMEL Peter, 平林義雄, 平林義雄

日本糖質学会年会要旨集, 39th, 2020

Works

Research Projects

Average orientation of lipid acyl chains in the domain structure of model membranes

Grants-in-Aid for Scientific Research, Grant-in-Aid for Challenging Research (Pioneering), Japan Society for the Promotion of Science, Jun, 2023 - Mar, 2026
Chemical study on dynamics of model lipid bilayers reproducing biomembrane under non-equilibrium conditions

Grants-in-Aid for Scientific Research, Grant-in-Aid for Scientific Research (A), Japan Society for the Promotion of Science, Apr, 2021 - Mar, 2025
Frontiers in Chemical Communications

Grants-in-Aid for Scientific Research, Grant-in-Aid for Scientific Research on Innovative Areas (Research in a proposed research area), Japan Society for the Promotion of Science, Jun, 2017 - Mar, 2022

Kakeya Hideaki
Dynamic conformation and domain structure of lipid molecules in model biomembranes

Grants-in-Aid for Scientific Research Grant-in-Aid for Scientific Research on Innovative Areas (Research in a proposed research area), Grant-in-Aid for Scientific Research on Innovative Areas (Research in a proposed research area), Japan Society for the Promotion of Science, Jun, 2017 - Mar, 2022

Murata Michio
Roles of lipid anchors and minor components in domain formation in biomembranes

Grants-in-Aid for Scientific Research, Grant-in-Aid for Challenging Research (Exploratory), Japan Society for the Promotion of Science, Jun, 2019 - Mar, 2021

Murata Michio
Dynamic conformation and domain structure of lipid molecules in model biomembranes

Grants-in-Aid for Scientific Research Grant-in-Aid for Scientific Research (S), Grant-in-Aid for Scientific Research (S), Japan Society for the Promotion of Science, May, 2016 - Mar, 2021

MURATA Michio
Depth-dependent melting of acyl chains and phase-transition of lipid bilayers

Grants-in-Aid for Scientific Research Grant-in-Aid for Challenging Exploratory Research, Grant-in-Aid for Challenging Exploratory Research, Japan Society for the Promotion of Science, Apr, 2016 - Mar, 2018

Murata Michio
Exploration of natural products and small molecues for mode-of-action study on biomembrane lipids

Grants-in-Aid for Scientific Research Grant-in-Aid for Scientific Research (A), Grant-in-Aid for Scientific Research (A), Japan Society for the Promotion of Science, May, 2013 - Mar, 2017

Murata Michio
Lipid-water interactions involved in membrane biofunctions

Grants-in-Aid for Scientific Research Grant-in-Aid for Challenging Exploratory Research, Grant-in-Aid for Challenging Exploratory Research, Japan Society for the Promotion of Science, Apr, 2014 - Mar, 2016

Murata Michio
Elucidation of Mechanisms on Membrane Protein Integration by a Glycolipid Acting Like an Enzyme

Grants-in-Aid for Scientific Research Grant-in-Aid for Scientific Research (B), Grant-in-Aid for Scientific Research (B), Japan Society for the Promotion of Science, Apr, 2013 - Mar, 2016

SHIMAMOTO Keiko, MIURA Kaoru, NISHIYAMA Ken-ichi, MURATA Michio
Structral analysis of amphotericin B channel complex using solid-state NMR

Grants-in-Aid for Scientific Research Grant-in-Aid for Young Scientists (B), Grant-in-Aid for Young Scientists (B), Japan Society for the Promotion of Science, Apr, 2013 - Mar, 2015

UMEGAWA Yuichi, MURATA Michio, MATSUMORI Nobuaki
Study on biosynthesis and secretion mechanisms of the sperm attracting factor in ascidians

Grants-in-Aid for Scientific Research, Grant-in-Aid for Challenging Exploratory Research, Japan Society for the Promotion of Science, Apr, 2012 - Mar, 2015

YOSHIDA Manabu, YOSHIDA Kaoru, MURATA Michio
Rapid conformational change results in attractive interactions between biomolecules

Grants-in-Aid for Scientific Research Grant-in-Aid for Challenging Exploratory Research, Grant-in-Aid for Challenging Exploratory Research, Japan Society for the Promotion of Science, Apr, 2012 - Mar, 2014

MURATA Michio
分子プローブを用いた脂質ラフトにおけるタンパク質-リン脂質相互作用の構造基盤解明

科学研究費助成事業, 特別研究員奨励費, 日本学術振興会, 2009 - 2011

村田道雄, GORETTA Sarah
生体小分子の化学構造と生理機能を結ぶ弱い分子間相互作用の記述

科学研究費助成事業挑戦的萌芽研究, 挑戦的萌芽研究, 日本学術振興会, 2009 - 2010

村田道雄
Analysis of molecular assemblage in lipid bilayers using bicelles

Grants-in-Aid for Scientific Research Grant-in-Aid for Scientific Research (B), Grant-in-Aid for Scientific Research (B), Japan Society for the Promotion of Science, 2008 - 2010

MATSUMORI Nobuaki, MURATA Michio
Structures and Functions of Membrane-Bound Biomolecules

Grants-in-Aid for Scientific Research Grant-in-Aid for Scientific Research (S), Grant-in-Aid for Scientific Research (S), Japan Society for the Promotion of Science, 2006 - 2010

MURATA Michio, OISHI Tohru, MATSUMORI Nobujaki, DOI Mototsugu
大腸菌におけるタンパク質膜挿入に関与する膜内在性新因子の構造決定

科学研究費助成事業, 萌芽研究, 日本学術振興会, 2006 - 2007

松森信明, 西山賢一, 村田道雄, 安達清治
膜蛋白質と相互作用する生体機能分子の合成と機能解析

科学研究費助成事業特定領域研究, 特定領域研究, 日本学術振興会, 2004 - 2007

大石徹, 村田道雄, 松森信明
自己組識化して活性を発現する天然物アンフィジノールの全合成と分子複合体の構造解析

科学研究費助成事業萌芽研究, 萌芽研究, 日本学術振興会, 2005 - 2006

大石徹, 村田道雄

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