2016年10月
Impact of feline AIM on the susceptibility of cats to renal disease
SCIENTIFIC REPORTS
- 巻
- 6
- 号
- 開始ページ
- 35251
- 終了ページ
- 記述言語
- 英語
- 掲載種別
- 研究論文(学術雑誌)
- DOI
- 10.1038/srep35251
- 出版者・発行元
- NATURE PUBLISHING GROUP
Renal failure is one of the most important social problems for its incurability and high costs for patients' health care. Through clarification of the underlying mechanism for the high susceptibility of cats to renal disease, we here demonstrates that the effective dissociation of serum AIM protein from IgM is necessary for the recovery from acute kidney injury (AKI). In cats, the AIM-IgM binding affinity is 1000-fold higher than that in mice, which is caused by the unique positively-charged amino-acid cluster present in feline AIM. Hence, feline AIM does not dissociate from IgM during AKI, abolishing its translocation into urine. This results in inefficient clearance of lumen-obstructing necrotic cell debris at proximal tubules, thereby impairing AKI recovery. Accordingly, mice whose AIM is replaced by feline AIM exhibit higher mortality by AKI than in wild-type mice. Recombinant AIM administration into the mice improves their renal function and survival. As insufficient recovery from AKI predisposes patients to chronic, end-stage renal disease, feline AIM may be involved crucially in the high mortality of cats due to renal disease. Our findings could be the basis of the development of novel AKI therapies targeting AIM-IgM dissociation, and may support renal function in cats and prolong their lives.
- リンク情報
-
- DOI
- https://doi.org/10.1038/srep35251 本文へのリンクあり
- J-GLOBAL
- https://jglobal.jst.go.jp/detail?JGLOBAL_ID=201702206835027319
- PubMed
- https://www.ncbi.nlm.nih.gov/pubmed/27731392
- Web of Science
- https://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=JSTA_CEL&SrcApp=J_Gate_JST&DestLinkType=FullRecord&KeyUT=WOS:000385001700002&DestApp=WOS_CPL
- URL
- http://europepmc.org/articles/PMC5059666
- URL
- http://orcid.org/0000-0002-5912-5647
- ID情報
-
- DOI : 10.1038/srep35251
- ISSN : 2045-2322
- J-Global ID : 201702206835027319
- ORCIDのPut Code : 47284451
- PubMed ID : 27731392
- Web of Science ID : WOS:000385001700002