論文

査読有り 国際誌
2020年11月

Endoscopic pressure study integrated system reflects gastroesophageal junction competence in patients with erosive esophagitis and Barrett´s esophagus.

Digestive endoscopy : official journal of the Japan Gastroenterological Endoscopy Society
  • Yugo Iwaya
  • ,
  • Haruhiro Inoue
  • ,
  • Enrique Rodríguez de Santiago
  • ,
  • Mary Raina Angeli Abad
  • ,
  • Yusuke Fujiyoshi
  • ,
  • Akiko Ueno
  • ,
  • Mayo Tanabe
  • ,
  • Kazuya Sumi
  • ,
  • Hideomi Tomida
  • ,
  • Masaki Ominami
  • ,
  • Haruo Ikeda
  • ,
  • Manabu Onimaru
  • ,
  • Yuto Shimamura

32
7
開始ページ
1050
終了ページ
1056
記述言語
英語
掲載種別
研究論文(学術雑誌)
DOI
10.1111/den.13644

OBJECTIVES: The endoscopic pressure study integrated system (EPSIS) is a novel diagnostic tool for gastroesophageal reflux disease (GERD) by monitoring intragastric pressure (IGP). Evaluation of the lower esophageal sphincter (LES) function may be achieved endoscopically by utilizing this newly developed diagnostic tool. This study aimed to evaluate the association between EPSIS results and gastroesophageal reflux-related diseases, e.g., erosive esophagitis (EE) and Barrett's esophagus (BE). METHODS: This was a retrospective, single-center study. All patients who underwent EPSIS between November 2016 and July 2018 were included. EPSIS was performed during esophagogastroduodenoscopy with a dedicated electronic device and a through-the-scope catheter. The maximum IGP (IGP-max) and IGP waveform pattern (flat or uphill) were recorded with this system. Evaluation of an EE and BE was based on the Los Angeles classification and Prague classification, respectively. RESULTS: A total of 104 patients were enrolled; 29 (28%) had EE and 42 (40%) had BE. Patients with EE had lower IGP-max values (16.0 vs 18.8 mmHg, P = 0.01) and an EPSIS flat pattern was seen more frequently (82.8% vs 37.3%, P < 0.001). Similarly, patients with BE displayed a lower IGP-max (15.7 vs 19.6 mmHg, P < 0.001) and presented with an EPSIS flat pattern in a higher proportion (69% vs 37.1%, P < 0.001). These differences remained significant on multivariate analysis. CONCLUSIONS: The EPSIS, as a novel diagnostic tool, was shown to exhibit a relation with EE and BE, implying that EPSIS is a promising modality to evaluate gastroesophageal reflux-related diseases and LES function endoscopically.

リンク情報
DOI
https://doi.org/10.1111/den.13644
PubMed
https://www.ncbi.nlm.nih.gov/pubmed/32012362
ID情報
  • DOI : 10.1111/den.13644
  • PubMed ID : 32012362

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