2003年
Effect of a tyrosine kinase inhibitor ST1571 in a patient with hepatic metastases from a duodenal gastrointestinal stromal tumor
JOURNAL OF GASTROENTEROLOGY
- 巻
- 38
- 号
- 7
- 開始ページ
- 690
- 終了ページ
- 694
- 記述言語
- 英語
- 掲載種別
- DOI
- 10.1007/s00535-002-1124-1
- 出版者・発行元
- SPRINGER-VERLAG TOKYO
Gastrointestinal stromal tumors (GISTS) are the most common mesenchymal tumors. The molecular etiology is the result of mutations in the c-Kit gene. The mutant c-Kit proteins, which are activated without a stem cell factor, contribute to the tumor development. STI571 selectively inhibits c-Kit, BCR-ABL, and PDGFR tyrosine kinases. Based on this potential to inhibit critical c-Kit function in GISTS, case studies have reported effective outcomes following treatment with STI571. This case report describes a highly effective use of STI571 in a 54-year-old woman with multiple liver metastases from a GIST originating in the duodenum.
- リンク情報
-
- DOI
- https://doi.org/10.1007/s00535-002-1124-1
- CiNii Articles
- http://ci.nii.ac.jp/naid/10013691020
- PubMed
- https://www.ncbi.nlm.nih.gov/pubmed/12898363
- Web of Science
- https://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=JSTA_CEL&SrcApp=J_Gate_JST&DestLinkType=FullRecord&KeyUT=WOS:000184452500011&DestApp=WOS_CPL
- ID情報
-
- DOI : 10.1007/s00535-002-1124-1
- ISSN : 0944-1174
- CiNii Articles ID : 10013691020
- PubMed ID : 12898363
- Web of Science ID : WOS:000184452500011