Yoshiyasu Fukuyama - My portal

Profile Information

Affiliation: Professor, Faculty of Pharmaceutical Sciences, Tokushima Bunri University

Degree: Ph.D(Osaka City University)

J-GLOBAL ID: 200901036831952353
researchmap Member ID: 0000034884

External link: http://www.ph.bunri-u.ac.jp/

Research Interests

Research Areas

Research History

Education

Committee Memberships

Apr, 2012 - Mar, 2013

徳島県献血推薦協議会委員, 徳島県献血推薦協議会
Apr, 2012 - Mar, 2013

徳島県薬事審議会委員, 徳島県
Apr, 2011 - Mar, 2013

徳島新聞賞候補者推薦委員, 徳島新聞
Apr, 2011 - Mar, 2013

編集委員, 日本薬学会
Sep, 2002 - Mar, 2003

学会賞第一次選考委員, 日本薬学会

Awards

Jun, 2006

Tokushima News Paer Award (Sicence), Chemical and Biological Studies on Plant-derived Biologically Active Substance, Tokushima News Paper

FUKUYAMA Yoshiyasu

Papers

162

The first examples of seco-prezizaane-type norsesquiterpenoids with neurotrophic activity from Illicium jiadifengpi

Miwa Kubo, Kana Kobayashi, Jian-Mei Huang, Kenichi Harada, Yoshiyasu Fukuyama

TETRAHEDRON LETTERS, 53(10) 1231-1235, Mar, 2012 Peer-reviewed
New Prenylated C-6-C-3 Compounds from the Twigs of Illicium anisatum

Miwa Kubo, Naoki Shima, Kenichi Harada, Hideaki Hioki, Yoshiyasu Fukuyama

CHEMICAL & PHARMACEUTICAL BULLETIN, 59(7) 898-901, Jul, 2011 Peer-reviewed
Asymmetric Synthesis of (-)-Chicanine Using a Higlhy Regioselective Intramolecular Mitsunobu Reaction and Revision of its Absolute Stereochemistry.

FUKUYAMA Yoshiyasu

Tetrahedron Lett., 52(23) 3005-3008, Jun, 2011 Peer-reviewed
Chemical Diversity of Vibsane-type Diterpenoids.

FUKUYAMA Yoshiyasu

Current Topics in Phytochemistry, 10(1) 39-53, May, 2011 Peer-reviewed
Synthesis of the ABC Ring System of Jiadifenin via Pd-Catalyzed Cyclizations

Kenichi Harada, Akiko Imai, Kazuharu Uto, Rich G. Carter, Miwa Kubo, Hideaki Hioki, Yoshiyasu Fukuyama

ORGANIC LETTERS, 13(5) 988-991, Mar, 2011 Peer-reviewed
Eight Clerodane DiterpenpAsymmetric Synthesis of (+)-Machilin F by Unusual Stereoselective Mitsunobu Reaction.

FUKUYAMA Yoshiyasu

Heterocyles, 82(2) 1127-1132, Feb, 2011 Peer-reviewed
Chemistry and Biological Activities of Vibsane-type Diterpenoids.

FUKUYAMA Yoshiyasu

Heterocyles, 81(7) 1571-1602, Jul, 2010 Peer-reviewedInvited
NGF-potentiating vibsane-type diterpenoids from Viburnum sieboldii

Miwa Kubo, Yoshiko Kishimoto, Kenichi Harada, Hideaki Hioki, Yoshiyasu Fukuyama

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 20(8) 2566-2571, Apr, 2010 Peer-reviewed
First Enantiocontrolled Formal Synthesis of (+)-Neovibsanin B, A Neurotrophic Diterpenoid

Tomoyuki Esumi, Takehiro Mori, Ming Zhao, Masao Toyota, Yoshiyasu Fukuyama

ORGANIC LETTERS, 12(4) 888-891, Feb, 2010 Peer-reviewed
Magnolol and honokiol prevent learning and memory impairment and cholinergic deficit in SAMP8 mice

Nobuaki Matsui, Kazuki Takahashi, Miho Takeichi, Touma Kuroshita, Kaori Noguchi, Kana Yamazaki, Hideaki Tagashira, Kenichi Tsutsui, Hideki Okada, Yuki Kido …

BRAIN RESEARCH, 1305 108-117, Dec, 2009 Peer-reviewed
Novel Pentacyclic seco-Prezizaane-Type Sesquiterpenoids with Neurotrophic Properties from Illicium jiadifengpi

Miwa Kubo, Chihiro Okada, Jian-Mei Huang, Kenichi Harada, Hideaki Hioki, Yoshiyasu Fukuyama

ORGANIC LETTERS, 11(22) 5190-5193, Nov, 2009 Peer-reviewed
Isolation, Synthesis, and Neurotrophic Activity of Illicinin A from the flowers of Illicium anisatum.

FUKUYAMA Yoshiyasu

Tetrahedron, 65(40) 8354-8361, Jun, 2009 Peer-reviewed
Novel NGF-potentiating diterpenoids from a Brazilian medicinal plant, Ptychopetalum olacoides

Wanxia Tang, Miwa Kubo, Kenichi Harada, Hideaki Hioki, Yoshiyasu Fukuyama

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 19(3) 882-886, Feb, 2009 Peer-reviewed
Synthesis of riccardin C and its seven analogues. Part 1: The role of their phenolic hydroxy groups as LXR alpha agonists

Hideaki Hioki, Naoki Shima, Kota Kawaguchi, Kenich Harada, Miwa Kubo, Tomoyuki Esumi, Tomoko Nishimaki-Mogami, Jun-ichi Sawada, Toshihiro Hashimoto, Yoshinori Asakawa …

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 19(3) 738-741, Feb, 2009 Peer-reviewed
Coumaroyl Triterpenes from Casuarina equisetifolia

Phytochemistry, 51(4), 543-550, 1999 Peer-reviewed
Convenient Syntheses of Neurotrophic Americanol A and Isoamericanol A by HRP Catalyzed Oxidative Coupling

Tetrahedron Letters, 40(16), 3185-3186, 1999 Peer-reviewed
An Example of Co-occurrence of Enantiomeric Labdane-type Diterpenes in the leaves of Mimosa hostilis

Chem. Pharm. Bull., 47(3), 454-455, 1999 Peer-reviewed
Aldovibsanins, Enol Ester Free Vibsane-type Diterpenes from Viburnum odoratissimum

Chem. Pharm. Bull., 47(2), 295-296, 1999 Peer-reviewed
Chemical Conversion of Vibsanin C to Vibsanin E and Structure of 3-Hydroxyvibsanin E

J. Nat. Prod., 62(2), 337-339, 1999 Peer-reviewed

Misc.

154

Xanthones and benzophenones from the stems of Garcinia multiflora

YM Chiang, YH Kuo, S Oota, Y Fukuyama

JOURNAL OF NATURAL PRODUCTS, 66(8) 1070-1073, Aug, 2003
Xanthones and benzophenones from the stems of Garcinia multiflora

YM Chiang, YH Kuo, S Oota, Y Fukuyama

JOURNAL OF NATURAL PRODUCTS, 66(8) 1070-1073, Aug, 2003
Synthesis and neuroprotective activity of bergenin derivatives with antioxidant activity

H Takahashi, M Kosaka, Y Watanabe, K Nakade, Y Fukuyama

BIOORGANIC & MEDICINAL CHEMISTRY, 11(8) 1781-1788, Apr, 2003
Synthesis and neuroprotective activity of bergenin derivatives with antioxidant activity

H Takahashi, M Kosaka, Y Watanabe, K Nakade, Y Fukuyama

BIOORGANIC & MEDICINAL CHEMISTRY, 11(8) 1781-1788, Apr, 2003
Structures of 1,4-Benzodioxane Derivatives from the Seeds of Phytolacca americana and Their Neuritogenic Activity in Primary Cultured Rat Cortical Neurons.

Chem. Pharm. Bull., 51, (12), 1377-1381, 2003
Determination of the Absolute Structure of Vibsanin F by Asymmetric Synthesis via p-allylpalladium complex.

Tetrahedron Lett., 44, (33), 6253-6239, 2003
Honokiol and Magnolol Induced Intracellar Ca2+ Mobilization in the Cultured Rat Cortical Neurons and Human Neuroblastoma SH-SY5Y.

Eurp. J. Pharmcol., 474, (2-3), 199-204, 2003
Seco-Prezizaane- and an Abitetan-type Terpenoids from Illicium miwanense.

J. Nat. Prod, 66, (6), 799-803, 2003
Structures of 1,4-Benzodioxane Derivatives from the Seeds of Phytolacca americana and Their Neuritogenic Activity in Primary Cultured Rat Cortical Neurons.

Chem. Pharm. Bull., 51, (12), 1377-1381, 2003
Determination of the Absolute Structure of Vibsanin F by Asymmetric Synthesis via p-allylpalladium complex.

Tetrahedron Lett., 44, (33), 6253-6239, 2003
Honokiol and Magnolol Induced Intracellar Ca2+ Mobilization in the Cultured Rat Cortical Neurons and Human Neuroblastoma SH-SY5Y.

Eurp. J. Pharmcol., 474, (2-3), 199-204, 2003
Seco-Prezizaane- and an Abitetan-type Terpenoids from Illicium miwanense

J. Nat. Prod., 66, (6), 799-803, 2003
Structures of Furanovibsanins A - G from Viburnum awbuki.

Tetrahedron, 58, (50) 10033-10041, 2002
The First Total Syhnthesis and Neurotrophic Activitry of Clusiparalicoline A, a Prenylated and Geranylated Biaryl from Clusia paralicola.

Tetrahedrom letters, 43(39), 6919-6923, 2002
Merrillianin, a unique seco-preziaane-type sesquiterpenes, and (6R)-pseudomajucin, from Illicium merrillianum.

Tetrahedron, 58(34), 6937-6941, 2002

Triterpenoids from Viburnum susupensum.

Phyto Chemistry, 60(8), 755-758, 2002

Total Synthesis of 7-O-Methyldehydropinguisenol by Palladium-catalyzed 1, 7-Enyne Cycloiosmerization.

Tetrahedron dettters, 43(21), 3829-3832, 2002

Neurotrophic Activity of Honokiol on the Culture of Fetal Rat Cortical Neurons.

Bioorg. Med. Chem. Lett., 12(8), 1163-1166, 2002

New Seco-prezizaane-type Sesquiterpenes, Jiadifenin and 1, 2-Dehydroneomajucin with Neurotrophic Activity from Illicium jiadifengpi.

J. Nat. Prod., 65(4), 527-531, 2002

Lignans and Sesquiterpenes from Magnoila praecosissima.

Chem. Pharm. Bull., 50(4), 541-543, 2002

More

Books and Other Publications
5

天然物の全合成 2000〜2008

福山愛保 (Role: Joint author, Vibsanin F の合成)

化学同人, May, 2009

天然物化学−植物編−（山村庄亮、長谷川宏司編）

福山愛保 (Role: Joint author, 4. 神経毒と神経突起、栄養因子活性物質)

アイピーシー, Nov, 2007

Studies in Natural Products Chemistry (edited by Attarr Rhamann) vol. 32

FUKUYAMA Yoshiyasu (Role: Joint author, 3. Chemistry and Neurotrophic Activity of Seco-Prezizaane- and Anislactone-type Sesquiterpenes from Illicium species.)

Elsevier, Oct, 2005

International Congress Series 1260. The Senescence-Accelerated Mouse (SAM): An Animal Model of Senescence

FUKUYAMA Yoshiyasu (Role: Joint author, Neuroprotective Effect of Magnolol in the Hippocampus of Senescence-accelerated Mice (SAMP1).)

Elsevier, Oct, 2004

Illicium, Pimpinella and Foeniculum

FUKUYAMA Yoshiyasu (Role: Joint author, Chemical Constituents of the genus Illicium)

CRC Press, May, 2004

Professional Memberships
12

有機合成化学協会

日本薬学会

日本生薬学会

日本化学会

国際ヘテロ環学会

アメリカ化学会

The pharmaceutical Society of Japan

The Japanese Society of Pharmacognosy

The International Society of Heterocyclic Chemistry

The Chemical Society of Japan

The American Chemical Society

Synthetic Organic Chemistry of Japan

Research Projects
6

神経栄養因子様活性化合物の化学的及び生物学的研究

科学研究費補助金, Apr, 2010 - Mar, 2012

福山愛保

食用植物由来の生理活性化合物の探索

JST, Apr, 2009 - Mar, 2010

福山愛保

Pd触媒を活用した生理活性物質の合成

科学研究費補助金, 2003 - 2010

Synthetic Studies on Biologically Active Substance by Using Pd Catalyst

1995 - 2010

Studies on Biologically Active Substances from Natural

1995 - 2010

Chemical and Biological Studies on Neurotrophic Substances

Grant-in-Aid for Scientific Research, 1995 - 2010

Industrial Property Rights
3

特願JP2009-148156 神経突起伸展促進新規化合物

福山愛保

特願JP2008-260691 神経細胞突起伸展作用を有する置換シクロヘキセンを有効成分として含有する植物を利用することを特徴とする健康組成物

福山愛保

特願JP2005-139153 トリシクロイリシノンを含む痴呆症治療薬

福山愛保

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