2005年7月
Postnatal development of excitation propagation in the trigeminal subnucleus caudalis evoked by afferent stimulation in mice
NEUROSCIENCE RESEARCH
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- 巻
- 52
- 号
- 3
- 開始ページ
- 201
- 終了ページ
- 210
- 記述言語
- 英語
- 掲載種別
- 研究論文(学術雑誌)
- DOI
- 10.1016/j.neures.2005.03.005
- 出版者・発行元
- ELSEVIER IRELAND LTD
The postnatal development of nociceptive afferent activity expansion and its modulation features were examined in mice using an optical imaging technique. Developing mice (1-2 weeks old (N 1-2w), 3-4 weeks old (N3-4w), 5-6 weeks old (N5-6w) and 7-8 weeks old (N7-8w)) and neonatally capsaicin-treated mice were used. The propagation of neuronal excitation was measured by changes in fluorescent intensity in horizontal brain stem slices evoked by electrical stimulation to the trigeminal spinal tract. A single-pulse stimulation evoked excitation propagation in the trigeminal caudalis (Vc). The propagation area was larger in N1-2w than in N7-8w, and no differences were observed between capsaicin-treated and naive mice in the same age groups. Repetitive stimulation (100 Hz, 30 pulses) elicited long-lasting and widespread excitation propagation. The excitation propagation area was significantly larger in N7-8w than in N1-2w, N3-4w and N5-6w. This propagation was suppressed by 5 mu M L-703.606, an NK1-receptor antagonist, suggesting that the repetitive stimulation-elicited excitation may require substance-P releases. Morphological observations demonstrated that the neural network in the Vc had grown by postnatal week 5. These results suggest that nociceptive afferent activity co-operatively matures with development of the network structure in the Vc, and that a mechanism for prolonged increase in central excitability is established during a later postnatal period. (c) 2005 Elsevier Ireland Ltd and the Japan Neuroscience Society. All rights reserved.
- リンク情報
- ID情報
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- DOI : 10.1016/j.neures.2005.03.005
- ISSN : 0168-0102
- PubMed ID : 15927721
- Web of Science ID : WOS:000229987900001