2008年10月
Neural-Activity-Dependent Release of S100B from Astrocytes Enhances Kainate-Induced Gamma Oscillations In Vivo
JOURNAL OF NEUROSCIENCE
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- 巻
- 28
- 号
- 43
- 開始ページ
- 10928
- 終了ページ
- 10936
- 記述言語
- 英語
- 掲載種別
- DOI
- 10.1523/JNEUROSCI.3693-08.2008
- 出版者・発行元
- SOC NEUROSCIENCE
S100B is the principal calcium-binding protein of astrocytes and known to be secreted to extracellular space. Although secreted S100B has been reported to promote neurite extension and cell survival via its receptor [receptor for advanced glycation end products (RAGE)], effects of extracellular S100B on neural activity have been mostly unexplored. Here, we demonstrate that secreted S100B enhances kainate-induced gamma oscillations. Local infusion of S100B in S100B(-/-) mice enhanced hippocampal kainate-induced gamma oscillations in vivo. In a complementary set of experiments, local application of anti-S100B antibody in wild-type mice attenuated the gamma oscillations. Both results indicate that the presence of extracellular S100B enhances the kainate-induced gamma oscillations. In acutely isolated hippocampal slices, kainate application increased S100B secretion in a neural-activity-dependent manner. Further pharmacological experiments revealed that S100B secretion was critically dependent on presynaptic release of neurotransmitter and activation of metabotropic glutamate receptor 3. Moreover, the kainate-induced gamma oscillations were attenuated by the genetic deletion or antibody blockade of RAGE in vivo. These results suggest RAGE activation by S100B enhances the gamma oscillations. Together, we propose a novel pathway of neuron-glia communications - astrocytic release of S100B modulates neural network activity through RAGE activation.
- リンク情報
- ID情報
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- DOI : 10.1523/JNEUROSCI.3693-08.2008
- ISSN : 0270-6474
- Web of Science ID : WOS:000260265700016