Noriyoshi Hashimoto

Profile Information

Affiliation: Advanced Science Research Center, Advanced Science Research Center, Kanazawa University

Degree: 博士(獣医学)(北海道大学)

J-GLOBAL ID: 200901014121721596
researchmap Member ID: 1000019823

Research Interests

Research Areas

Life sciences / Laboratory animal science /

Research History

Education

- 1992

Hokkaido University
- 1992

Graduate School, Division of Veterinary Medicine, Hokkaido University
- 1987

Veterinary Medicine, School of Veterinary Medicine, Hokkaido University
- 1987

Faculty of Veterinary Medicine, Hokkaido University

Awards

1996

(財)放射線影響協会研究奨励助成

Papers

Galactosyl carbohydrate residues on hematopoietic stem/progenitor cells are essential for homing and engraftment to the bone marrow.

Soichiro Takagaki, Rieko Yamashita, Noriyoshi Hashimoto, Kazushi Sugihara, Kanako Kanari, Keisuke Tabata, Toshikazu Nishie, Shogo Oka, Masanori Miyanishi, Chie Naruse …

Scientific reports, 9(1) 7133-7133, May 9, 2019 Peer-reviewed
Modulation of CD4(+) T cell responses following splenectomy in hepatitis C virus-related liver cirrhosis

N. Hashimoto, S. Shimoda, H. Kawanaka, K. Tsuneyama, H. Uehara, T. Akahoshi, N. Kinjo, A. Taketomi, K. Shirabe, K. Akashi …

CLINICAL AND EXPERIMENTAL IMMUNOLOGY, 165(2) 243-250, Aug, 2011 Peer-reviewed
糖尿病腎症におけるRAGEの役割の解明 RAGEノックアウトマウス(RAGE-/-)を用いて

山本靖彦, 土井俊夫, 加藤一郎, 櫻井繁, 米倉秀人, 渡辺琢夫, Myint Khin Mar, 原島愛, 高澤伸, 岡本宏 …

糖尿病, 47(Suppl.1) S177-S177, Apr, 2004
血液脳関門におけるカルニチン/有機カチオントランスポーターOCTN2の機能発現

大成亜希, 木戸康人, 加々美徹, 崔吉道, 二階堂浩子, 橋本憲佳, 浅野雅秀, 玉井郁巳, 辻彰

薬物動態, 15(Suppl.) S164-S164, Sep, 2000
jvsマウスを用いた有機カチオン性物質の体内動態変動解析

山口佳一, 崔吉道, 玉井郁巳, 辻彰, 橋本憲佳, 二階堂浩子

日本薬学会年会要旨集, 120年会(4) 58-58, Mar, 2000
先天的カルニチン欠損 JVS マウスの脂肪肝に与える γ-ブチロべタインの効果

横川弘一, 東康彦, 玉井郁巳, 辻彰, 橋本憲佳, 早川純一郎, 宮本謙一

臨床薬理, 31(2) 443-444, Feb 1, 2000
一次性全身カルニチン欠乏症発症原因としてのカルニチントランスポーターOCTN2の機能変動遺伝的カルニチン欠乏マウス(jvs)を用いた解析

大橋力也, 玉井郁巳, 崔吉道, 辻彰, 根津淳一, 奥飛鳥, 嶋根みゆき, 橋本憲佳, 二階堂浩子, 早川純一郎

日本薬学会年会要旨集, 119年会(4) 25-25, Mar, 1999
New immunodeficient mouse strains bred by introducing beige and xid mutations into the KSN nude strain

Y Ishigaki, J Hayakawa, N Hashimoto, H Nikaido, O Nikaido

LABORATORY ANIMAL SCIENCE, 46(4) 418-424, Aug, 1996 Peer-reviewed
Mapping of jvs (juvenile visceral steatosis) gene, which causes systemic carnitine deficiency in mice, on Chromosome 11

H. Nikaido, M. Horiuchi, N. Hashimoto, T. Saheki, J. Hayakawa

Mammalian Genome, 6(5) 369-370, May, 1995 Peer-reviewed

Misc.

Hemophagocytic syndrome-like disorders in asparaginyl endopeptidase-deficient mice

63(6) 634-639, Dec, 2011
Mice lacking asparaginyl endopeptidase develop disorders resembling hemophagocytic syndrome (vol 106, pg 468, 2008)

Chi-Bun Chan, Michiyo Abe, Noriyoshi Hashimoto, Chunhai Hao, Ifor R. Williams, Xia Liu, Shinji Nakao, Akitsugu Yamamoto, Chengyun Zheng, Jan-Inge Henter …

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 106(14) 6023-6023, Apr, 2009
Mice lacking asparaginyl endopeptidase develop disorders resembling hemophagocytic syndrome

Chi-Bun Chan, Michiyo Abe, Noriyoshi Hashimoto, Chunhai Hao, Ifor R. Williams, Xia Liu, Shinji Nakao, Akitsugu Yamamoto, Shi-Yong Li, Ikuko Hara-Nishimura …

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 106(2) 468-473, Jan, 2009
Mice lacking asparaginyl endopeptidase develop disorders resembling hemophagocytic syndrome

Chi-Bun Chan, Michiyo Abe, Noriyoshi Hashimoto, Chunhai Hao, Ifor R. Williams, Xia Liu, Shinji Nakao, Akitsugu Yamamoto, Shi-Yong Li, Ikuko Hara-Nishimura …

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 106(2) 468-473, Jan, 2009
Development of immunoglobulin A nephropathy-like disease in beta-1,4-galactosyltransferase-I-deficient mice

Toshikazu Nishie, Osamu Miyaishi, Haruhito Azuma, Akihiko Kameyama, Chile Naruse, Noriyoshi Hashimoto, Hitoshi Yokoyama, Hisashi Narimatsu, Takashi Wada, Masahide Asano

AMERICAN JOURNAL OF PATHOLOGY, 170(2) 447-456, Feb, 2007
Development of immunoglobulin A nephropathy-like disease in beta-1,4-galactosyltransferase-I-deficient mice

Toshikazu Nishie, Osamu Miyaishi, Haruhito Azuma, Akihiko Kameyama, Chile Naruse, Noriyoshi Hashimoto, Hitoshi Yokoyama, Hisashi Narimatsu, Takashi Wada, Masahide Asano

AMERICAN JOURNAL OF PATHOLOGY, 170(2) 447-456, Feb, 2007
Development of IgA nephropathy-like disease with high serum IgA levels and increased proportion of polymeric IgA in β-1,4-galactosyltransferase- deficient mice

Toshikazu Nishie, Osamu Miyaishi, Haruhito Azuma, Akihiko Kameyama, Chie Naruse, Noriyoshi Hashimoto, Hitoshi Yokoyama, Hisashi Narimatsu, Takashi Wada, Masahide Asano

Contributions to Nephrology, 157 125-128, 2007
Development of IgA nephropathy-like disease with high serum IgA levels and increased proportion of polymeric IgA in β-1,4-galactosyltransferase- deficient mice

Toshikazu Nishie, Osamu Miyaishi, Haruhito Azuma, Akihiko Kameyama, Chie Naruse, Noriyoshi Hashimoto, Hitoshi Yokoyama, Hisashi Narimatsu, Takashi Wada, Masahide Asano

Contributions to Nephrology, 157 125-128, 2007
RAGE control of diabetic nephropathy in a mouse model: effects of RAGE gene disruption and administration of low-molecular weight heparin.

Khin-Mar Myint, Yasuhiko Yamamoto, Toshio Doi, Ichiro Kato, Ai Harashima, Hideto Yonekura, Takuo Watanabe, Harumichi Shinohara, Masayoshi Takeuchi, Koichi Tsuneyama …

Diabetes, 55(9) 2510-22, Sep, 2006
RAGE control of diabetic nephropathy in a mouse model - Effects of RAGE gene disruption and administration of low-molecular weight heparin

Khin-Mar Myint, Yasuhiko Yamamoto, Toshio Doi, Ichiro Kato, Ai Harashima, Hideto Yonekura, Takuo Watanabe, Harumichi Shinohara, Masayoshi Takeuchi, Koichi Tsuneyama …

DIABETES, 55(9) 2510-2522, Sep, 2006
Receptor for advanced glycation end products is a promising target of diabetic nephropathy.

Yasuhiko Yamamoto, Toshio Doi, Ichiro Kato, Harumichi Shinohara, Shigeru Sakurai, Hideto Yonekura, Takuo Watanabe, Kihn Mar Myint, Ai Harashima, Masayoshi Takeuchi …

Annals of the New York Academy of Sciences, 1043 562-6, Jun, 2005
Receptor for advanced glycation end products is a promising target of diabetic nephropathy

Y Yamamoto, T Doi, Kato, I, H Shinohara, S Sakurai, H Yonekura, T Watanabe, KM Myint, A Harashima, M Takeuchi …

MAILLARD REACTION: CHEMISTRY AT THE INTERFACE OF NUTRITION, AGING, AND DISEASE, 1043 562-566, 2005
Impaired selectin-ligand biosynthesis and reduced inflammatory responses in beta-1,4-galactosyltransferdse-I-deficient mice

M Asano, S Nakae, N Kotani, N Shirafuji, A Nambu, N Hashimoto, H Kawashima, M Hirose, M Miyasaka, S Takasaki …

BLOOD, 102(5) 1678-1685, Sep, 2003
Impaired selectin-ligand biosynthesis and reduced inflammatory responses in beta-1,4-galactosyltransferdse-I-deficient mice

M Asano, S Nakae, N Kotani, N Shirafuji, A Nambu, N Hashimoto, H Kawashima, M Hirose, M Miyasaka, S Takasaki …

BLOOD, 102(5) 1678-1685, Sep, 2003
Biosynthetic processing of cathepsins and lysosomal degradation are abolished in asparaginyl endopeptidase-deficient mice

K Shirahama-Noda, A Yamamoto, K Sugihara, N Hashimoto, M Asano, M Nishimura, Hara-Nishimura, I

JOURNAL OF BIOLOGICAL CHEMISTRY, 278(35) 33194-33199, Aug, 2003
Biosynthetic processing of cathepsins and lysosomal degradation are abolished in asparaginyl endopeptidase-deficient mice

K Shirahama-Noda, A Yamamoto, K Sugihara, N Hashimoto, M Asano, M Nishimura, Hara-Nishimura, I

JOURNAL OF BIOLOGICAL CHEMISTRY, 278(35) 33194-33199, Aug, 2003
Functional relevance of carnitine transporter OCTN2 to brain distribution of L-carnitine and acetyl-L-carnitine across the blood-brain barrier

Y Kido, Tamai, I, A Ohnari, Y Sai, T Kagami, J Nezu, H Nikaido, N Hashimoto, M Asano, A Tsuji

JOURNAL OF NEUROCHEMISTRY, 79(5) 959-969, Dec, 2001
Functional relevance of carnitine transporter OCTN2 to brain distribution of L-carnitine and acetyl-L-carnitine across the blood-brain barrier

Y Kido, Tamai, I, A Ohnari, Y Sai, T Kagami, J Nezu, H Nikaido, N Hashimoto, M Asano, A Tsuji

JOURNAL OF NEUROCHEMISTRY, 79(5) 959-969, Dec, 2001
マイクロダイアリシス法を用いたOCTN2トランスポーターの血液脳関門における機能発現評価

稲野彰洋, 崔吉道, 二階堂浩子, 橋本憲佳, 浅野雅秀, 玉井郁巳, 辻彰

薬物動態 = Xenobiotic metabolism and disposition, 16 S181, Sep 17, 2001
Effect of gamma-butyrobetaine on fatty liver in juvenile visceral steatosis mice

Y Higashi, K Yokogawa, N Takeuchi, Tamai, I, M Nomura, N Hashimoto, JI Hayakawa, KI Miyamoto, A Tsuji

JOURNAL OF PHARMACY AND PHARMACOLOGY, 53(4) 527-533, Apr, 2001

Professional Memberships

Research Projects

Development of new albino inbred strain mice for embryo-transfer recipient

Grants-in-Aid for Scientific Research, Grant-in-Aid for Scientific Research (C), Japan Society for the Promotion of Science, Apr, 2018 - Mar, 2021

Hashimoto Noriyoshi
科学研究費補助金, 胚移植レシピエントのための新規アルビノ近交系マウスの開発

Apr, 2018 - Mar, 2021

橋本憲佳
Identification of novel homing molecules of hematopoietic stem cells and development of efficient bone marrow transfer methods by modifying carbohydrates

Grants-in-Aid for Scientific Research, Grant-in-Aid for Challenging Exploratory Research, Japan Society for the Promotion of Science, 2011 - 2013

ASANO Masahide, HASHIMOTO Noriyoshi
Characterization of AEP/Legumain-deficient mice as a new model of lysosome disease

Grants-in-Aid for Scientific Research, Grant-in-Aid for Scientific Research (C), Japan Society for the Promotion of Science, 2009 - 2011

HASHIMOTO Noriyoshi, ASANO Masahide
アスパラギンエンドペプチダーゼ欠損による血球貪食症候群様病態の解析

科学研究費補助金, 2006 - 2011
Analysis of Hemophagocytic syndrome like disease in legumain deficient mice

Grant-in-Aid for Scientific Research, 2006 - 2011
Development of mouse models for human diseases caused by impaired glycosylation and analysis of their mechanisms

Grants-in-Aid for Scientific Research, Grant-in-Aid for Scientific Research (B), Japan Society for the Promotion of Science, 2007 - 2009

ASANO Masahide, HASHIMOTO Noriyoshi, YOSHIHARA Toru, SUGIHARA Kazushi
Characterization of AEP/Legumain-deficient mice as a model of hemophagocytic syndrome-like disease

Grants-in-Aid for Scientific Research, Grant-in-Aid for Scientific Research (C), Japan Society for the Promotion of Science, 2006 - 2008

HASHIMOTO Noriyoshi, ASANO Masahide
β4-ガラクトース転移酵素-I欠損によるIga腎症発症機構の解析

科学研究費助成事業, 特定領域研究, 日本学術振興会, 2005 - 2006

浅野雅秀, 橋本憲佳, 成瀬智恵, 杉原一司
自己免疫疾患におけるアスパラギンエンドペプチダーゼによる免疫記憶の調節

科学研究費助成事業, 特定領域研究, 日本学術振興会, 2004 - 2004

浅野雅秀, 橋本憲佳, 西村いくこ
ORC4変異マウスを用いた個体レベルでの細胞周期研究

科学研究費助成事業, 萌芽研究, 日本学術振興会, 2003 - 2004

浅野雅秀, 成瀬智恵, 橋本憲佳
Functional analysis of carbohydrate antigens in chemically induced tumor cells derived from beta-1,4-galactosyltransferase-I knockout mice

Grants-in-Aid for Scientific Research, Grant-in-Aid for Scientific Research (C), Japan Society for the Promotion of Science, 2003 - 2004

HASHIMOTO Noriyoshi, ASANO Masahide
アスパラギンエンドペプチダーゼの免疫系での機能解析

2004
改良遺伝子トラップ法による新規発生制御遺伝子の単離と機能解析

科学研究費助成事業, 特定領域研究, 日本学術振興会, 2002 - 2003

浅野雅秀, 成瀬智恵, 橋本憲佳
Elucidation of individual roles of the galactosyl|ransferase gene family using gene knockout mice

Grants-in-Aid for Scientific Research, Grant-in-Aid for Scientific Research (B), Japan Society for the Promotion of Science, 2001 - 2003

ASANO Masahide, HASHIMOTO Noriyoshi
糖転移酵素遺伝子欠損マウスを用いた発癌・転移における糖鎖機能の解析

科学研究費助成事業, 特定領域研究(C), 日本学術振興会, 2001 - 2001

浅野雅秀, 橋本憲佳
改良遺伝子トラップ法による新規発生制御遺伝子の単離と機能解析

科学研究費助成事業, 特定領域研究(A), 日本学術振興会, 2001 - 2001

浅野雅秀, 橋本憲佳
糖転移酵素遺伝子欠損マウスを用いた発癌・転移における糖鎖機能の解析

科学研究費助成事業, 特定領域研究(C), 日本学術振興会, 2000 - 2000

浅野雅秀, 橋本憲佳
ガラクトース転移酵素遺伝子ノックアウトマウスを用いた糖鎖機能の解析

科学研究費助成事業, 特定領域研究(A), 日本学術振興会, 2000 - 2000

浅野雅秀, 橋本憲佳
Functional analysis of IL-1 in immune and stress responses using gene knockout mice

Grants-in-Aid for Scientific Research, Grant-in-Aid for Scientific Research (C), Japan Society for the Promotion of Science, 1998 - 2000

ASANO Masahide, HASHIMOTO Noriyoshi, SUDO Katsuko, IWAKURA Yoichiro

Profile Information

Research Interests

Research Areas

Research History

Education

Awards

Papers

Misc.

Professional Memberships

Research Projects

Menu

Coauthors