2019年8月
Application of liposome membrane as the reaction field: A case study using the Horner–Wadsworth–Emmons reaction
Journal of Bioscience and Bioengineering
- ,
- ,
- 巻
- 128
- 号
- 2
- 開始ページ
- 198
- 終了ページ
- 202
- 記述言語
- 掲載種別
- 研究論文(学術雑誌)
- DOI
- 10.1016/j.jbiosc.2019.01.015
The properties of the liposome membrane as a reaction field were investigated by focusing on the Horner–Wadsworth–Emmons reaction as a case study. Use of the liposomes existing in the gel phase resulted in the enhanced activity of the substrates and furnished the products with same E/Z stereoselectivity as in the liposome-free system. The membrane environment in the gel phase most likely assisted the formation of adducts that induced selective generation of the E-isomer. The possible role of liposomes is to assist the proton removal from the reactant, rather than providing the basic interfacial environment.
- リンク情報
- ID情報
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- DOI : 10.1016/j.jbiosc.2019.01.015
- ISSN : 1389-1723
- eISSN : 1347-4421
- PubMed ID : 30827857
- SCOPUS ID : 85062177929