2007年8月
Zygotic gene activation and maternal factors in mammals.
The Journal of reproduction and development
- ,
- ,
- 巻
- 53
- 号
- 4
- 開始ページ
- 707
- 終了ページ
- 15
- 記述言語
- 英語
- 掲載種別
- 研究論文(学術雑誌)
- DOI
- 10.1262/jrd.19029
Zygotic gene activation (ZGA) is the first event of gene expression after fertilization. Following fertilization, ZGA occurs within a short time interval depending on the animal species. Until ZGA, maternal proteins and transcripts stored in oocytes control embryonic development, indicating the importance of maternal factors for development. Somatic cell cloning also proves the potential of oocyte to reprogram the differentiated cell nuclei to embryonic nuclei. Recent studies show that the epigenetic modifications of nuclei play important roles in controlling gene expression during ZGA. However, the mechanisms that control ZGA remain largely unknown. This review will cover the current understanding of ZGA. Specifically, it will focus on the maternal factors that control gene expression during early embryogenesis.
- リンク情報
- ID情報
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- DOI : 10.1262/jrd.19029
- ISSN : 0916-8818
- CiNii Articles ID : 10011283463
- PubMed ID : 17827882