2002年1月
Up-regulation of Hrk, a regulator of cell death, in retinal ganglion cells of axotomized rat retina
Neuroscience Letters
- ,
- ,
- 巻
- 318
- 号
- 2
- 開始ページ
- 77
- 終了ページ
- 80
- 記述言語
- 英語
- 掲載種別
- DOI
- 10.1016/s0304-3940(01)02487-9
- 出版者・発行元
- Elsevier BV
Hrk, a regulator of cell death, belongs to the family of pro-apoptotic BH3-only proteins and is known to induce apoptosis in nerve tissue. We examined Hrk gene expression to clarify the role of BH3-only proteins in apoptosis of retinal ganglion cells (RGCs) after optic nerve transection in the adult rat. Reverse transcription-polymerase chain reaction showed that Hrk was up-regulated in retina from 12 h after axotomy, and continued to be elevated for 1 week. In situ hybridization histochemistry revealed that Hrk was expressed in a sub-population of axotomized RGCs. These results suggest that Hrk is involved in the induction of apoptosis in RGCs after optic nerve transection. (C) 2002 Elsevier Science Ireland Ltd. All rights reserved.
- リンク情報
- ID情報
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- DOI : 10.1016/s0304-3940(01)02487-9
- ISSN : 0304-3940
- Web of Science ID : WOS:000173598700007