1995年
Localization of advanced glycation endproducts in the kidney of experimental diabetic rats
Journal of Diabetes and Its Complications
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- 巻
- 9
- 号
- 4
- 開始ページ
- 269
- 終了ページ
- 271
- 記述言語
- 英語
- 掲載種別
- DOI
- 10.1016/1056-8727(95)80019-B
Advanced glycation endproducts (AGE) have been proposed as a major mediator in the development of various diabetic complications. In order to evaluate the involvement of AGE in the development of diabetic nephropathy, we examined the localization of AGE in the kidney of the streptozotocin-induced diabetic rats immunohistochemically using a monoclonal antibody directed to AGE. In the diabetic rats, glomerular hypertrophy, thickening of the glomerular basement membrane, and expansion of mesangial matrix were observed. AGE was detected in expanded mesangial area and glomerular basement membrane in the kidneys of diabetic rats. The present results suggest that AGE may participate in the development of diabetic nephropathy. © 1995.
- リンク情報
- ID情報
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- DOI : 10.1016/1056-8727(95)80019-B
- ISSN : 1056-8727
- PubMed ID : 8573744
- SCOPUS ID : 0028791830