1999年
Effective production of dehydro cyclic dipeptide albonoursin exhibiting pronuclear fusion inhibitory activity. I. Taxonomy and fermentation
Journal of Antibiotics
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- 巻
- 52
- 号
- 11
- 開始ページ
- 1017
- 終了ページ
- 1022
- 記述言語
- 英語
- 掲載種別
- DOI
- 10.7164/antibiotics.52.1017
- 出版者・発行元
- Japan Antibiotics Research Association
Strain KO-23, an actinomycete producing albonoursin as well as streptopyrone, was identified as Streptomyces albulus by morphological and biochemical studies. Fermentation conditions for albonoursin, a dehydro cyclic dipeptide exhibiting a pronounced inhibitory activity toward pronuclear fusion of sea urchin eggs, were optimized. Under the optimum conditions, the actinomycete produced 16 mg/liter of albonoursin, 30 times higher than that in the original culture. The cells cultivated under these conditions highly express biosynthetic enzymes for albonoursin, and thus are available for biosynthetic studies of dehydro cyclic peptides.
- リンク情報
- ID情報
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- DOI : 10.7164/antibiotics.52.1017
- ISSN : 0021-8820
- PubMed ID : 10656574
- SCOPUS ID : 0032762124