2013年6月
POLYCYCLIC N-HETEROCYCLIC COMPOUNDS, PART 77: SYNTHESIS OF [1]BENZOTHIENO[3 ',2 ':2,3]OXEPINO[4,5-d]PYRIMIDINES AND EVALUATION OF THEIR ANTIPLATELET AGGREGATION ACTIVITY
SYNTHETIC COMMUNICATIONS
- ,
- ,
- ,
- 巻
- 43
- 号
- 12
- 開始ページ
- 1619
- 終了ページ
- 1625
- 記述言語
- 英語
- 掲載種別
- DOI
- 10.1080/00397911.2012.656295
- 出版者・発行元
- TAYLOR & FRANCIS INC
Reaction of 3-(3-cyanopropoxy)[1]benzothiophene-2-carbonitrile with sodium hydride gave 5-amino-1,2-dihydro[1]benzothieno[3,2-d]furo[2,3-b]pyridine and 5-amino-2,3-dihydro[1]benzothieno[3,2-b]oxepin-4-carbonitrile. The latter compound served as a convenient scaffold for the synthesis of the new heterocycles [1]benzothieno[3,2:2,3]oxepino[4,5-d]pyrimidines and the parent 1,2,4,5-tetrahydro[1]benzothieno[2,3:6,7]oxepino[4,5-e]imidazo[1,2-c]pyrimidine heterocyclic system. The new compounds described in this report were evaluated as inhibitors of platelet aggregation in vitro.
- リンク情報
- ID情報
-
- DOI : 10.1080/00397911.2012.656295
- ISSN : 0039-7911
- eISSN : 1532-2432
- Web of Science ID : WOS:000322303000002