Sakae Arimoto

Profile Information

Affiliation: Associate Professor, Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University

Degree: Ph. D.(Okayama University)

Researcher number: 90212654
J-GLOBAL ID: 200901065009971427
researchmap Member ID: 1000036045

External link: https://pxy-www.a.okayama-u.ac.jp/user/genetox/

Research Interests

Research Areas

Papers

132

Antimutagenic, anti-inflammatory, and antioxidative activities of the juice of Vitis ficifolia var. Ganebu, a woody vine in the grape family, known as Ryukyu-ganebu in Japan

Sakae Arimoto-Kobayashi, Ryoko Hida, Nana Fujii, Ryosuke Mochioka

Genes and Environment, 43(1), Dec, 2021 Peer-reviewedLead authorCorresponding author
Chemopreventive effects and anti-tumorigenic mechanisms of 2,6-dimethoxy-1,4-benzoquinone, a constituent of Vitis coignetiae Pulliat (crimson glory vine, known as yamabudo in Japan), toward 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK)-induced lung tumorigenesis in A/J mice

Sakae Arimoto-Kobayashi, Kensuke Sasaki, Ryoko Hida, Naoko Miyake, Nana Fujii, Yusuke Saiki, Kyohei Daimaru, Hirono Nakashima, Toshio Kubo, Katsuyuki Kiura

Food and Chemical Toxicology, 154 112319-112319, Aug, 2021 Peer-reviewedLead authorCorresponding author
Protective effect of Actinidia arguta in MPTP-induced Parkinson’s disease model mice

Yuki Kitamura, Mayuko Sakanashi, Azuki Ozawa, Yuri Saeki, Ayano Nakamura, Yuiho Hara, Ken-ichi Saeki, Sakae Arimoto-Kobayashi

Biochemical and Biophysical Research Communications, 555 154-159, May, 2021 Peer-reviewed
Isolation of new photoadducts from UVA-irradiated N-nitrosoproline with 2'-deoxyadenosine and characterization of photoadducts from DNA irradiated with N-nitrosoproline

Chiharu Asahi, Shuhei Aoyama, Sachiko Kimura, Toshinori Suzuki, Tsutomu Hatano, Sakae Arimoto-Kobayashi

Journal of Photochemistry and Photobiology A: Chemistry, 400 112621-112621, Sep, 2020 Peer-reviewedLast authorCorresponding author
Cytotoxic Effects of Alcohol Extracts from a Plastic Wrap (Polyvinylidene Chloride) on Human Cultured Liver Cells and Mouse Primary Cultured Liver Cells.

Ken-Ichi Yamamoto, Hiroko Kagawa, Sakae Arimoto, Xian Wen Tan, Kento Yasui, Toshiyuki Oshiki, Masakiyo Sakaguchi

Acta medica Okayama, 74(4) 327-334, Aug, 2020 Peer-reviewed
Mismatch repair systems might facilitate the chromosomal recombination induced by N-nitrosodimethylamine, but not by N-nitrosodiethylamine, in Drosophila

Tomoe Negishi, Kenji Yamada, Keiko Miyamoto, Emiko Mori, Kentaro Taira, Asei Fujii, Yuki Goto, Sakae Arimoto-Kobayashi, Keinosuke Okamoto

Mutagenesis, 35(2) 197-206, Mar 27, 2020 Peer-reviewed
Chloroethylating anticancer drug-induced mutagenesis and its repair in Escherichia coli

Yoko Yamada, Shinji Watanabe, Keinosuke Okamoto, Sakae Arimoto, Eizo Takahashi, Kazuo Negishi, Tomoe Negishi

Genes and Environment, 41(1), Dec, 2019 Peer-reviewed
Isolation and identification of photoproducts from UVA-irradiated mixture of N-nitrosoproline with 2'-deoxyadenosine

Shuhei Aoyama, Chiharu Asahi, Kayoko Sano, Sachiko Kimura, Toshinori Suzuki, Tsutomu Hatano, Sakae Arimoto-Kobayashi

Journal of Photochemistry and Photobiology A: Chemistry, 377 159-166, May, 2019 Peer-reviewedLast authorCorresponding author
2,6-Dimethoxy-1,4-benzoquinone, isolation and identification of anti-carcinogenic, anti-mutagenic and anti-inflammatory component from the juice of Vitis coignetiae

Tomonori Kamiya, Yusuke Tanimoto, Nana Fujii, Tomoe Negishi, Toshinori Suzuki, Tsutomu Hatano, Sakae Arimoto-Kobayashi

Food and Chemical Toxicology, 122 172-180, Dec, 2018 Peer-reviewedLast authorCorresponding author
UV-irradiated 2-methyl-4′-(methylthio)-2-morpholinopropiophenone-containing injection solution produced frameshift mutations in the Ames mutagenicity assay

Mariko Takai, Yoichi Kawasaki, Sakae Arimoto, Yusuke Tanimoto, Yoshihisa Kitamura, Toshiaki Sendo

Environmental Science and Pollution Research, 25(10) 10135-10140, Apr, 2018 Peer-reviewed
Increase of somatic cell mutations in oxidative damage-sensitive drosophila

Ryota Koike, Tomoyo Uchiyama, Sakae Arimoto-Kobayashi, Keinosuke Okamoto, Tomoe Negishi

Genes and Environment, 40(1), 2018
Mutation spectrum resulting in M13mp2 phage DNA exposed to N -nitrosoproline with UVA irradiation

Yumi Horai, Yoshiko Ando, Sachiko Kimura, Sakae Arimoto-Kobayashi

Mutation Research/Genetic Toxicology and Environmental Mutagenesis, 821 1-4, Sep, 2017 Peer-reviewedLast authorCorresponding author
E. coli mismatch repair enhances AT-to-GC mutagenesis caused by alkylating agents

Kota Nakano, Yoko Yamada, Eizo Takahashi, Sakae Arimoto, Keinosuke Okamoto, Kazuo Negishi, Tomoe Negishi

MUTATION RESEARCH-GENETIC TOXICOLOGY AND ENVIRONMENTAL MUTAGENESIS, 815 22-27, Mar, 2017
Somatic-cell mutation induced by short exposures to cigarette smoke in urate-null, oxidative stress-sensitive Drosophila

Tomoyo Uchiyama, Ryota Koike, Yoko Yuma, Keinosuke Okamoto, Sakae Arimoto-Kobayashi, Toshinori Suzuki, Tomoe Negishi

MUTAGENESIS, 31(1) 9-15, Jan, 2016
Indolo[3,2-b]quinoline Derivatives Suppressed the Hemolytic Activity of Beta-Pore Forming Toxins, Aerolysin-Like Hemolysin Produced by Aeromonas sobria and Alpha-Hemolysin Produced by Staphylococcus aureus

Eizo Takahashi, Chiaki Fujinami, Teruo Kuroda, Yasuo Takeuchi, Shin-ichi Miyoshi, Sakae Arimoto, Tomoe Negishi, Keinosuke Okamoto

BIOLOGICAL & PHARMACEUTICAL BULLETIN, 39(1) 114-120, Jan, 2016
Inhibitory effect of Actinidia arguta on mutagenesis, inflammation and two-stage mouse skin tumorigenesis

Mari Nishimura, Yuma Okimasu, Naoko Miyake, Misako Tada, Ryoko Hida, Tomoe Negishi, Sakae Arimoto-Kobayashi

Genes and Environment, 38(1), 2016
Mutagenicity and clastogenicity of extracts of Helicobacter pylori detected by the Ames test and in the micronucleus test using human lymphoblastoid cells

Sakae Arimoto-Kobayashi, Kaori Ohta, Yuta Yuhara, Yuka Ayabe, Tomoe Negishi, Keinosuke Okamoto, Yoshihiro Nakajima, Takeshi Ishikawa, Keiji Oguma, Takanao Otsuka

MUTAGENESIS, 30(4) 537-544, Jul, 2015
Properties of Hemolysin and Protease Produced by Aeromonas trota

Eizo Takahashi, Haruka Ozaki, Yoshio Fujii, Hidetomo Kobayashi, Hiroyasu Yamanaka, Sakae Arimoto, Tomoe Negishi, Keinosuke Okamoto

PLOS ONE, 9(3), Mar, 2014
Near ultraviolet radiation-mediated reaction between N-nitrosoproline and DNA: Isolation and identification of two new adducts, (R)- and (S)-8-(2-pyrrolidyl)-2 '-deoxyguanosine

Shuhei Aoyama, Kayoko Sano, Chiharu Asahi, Masaki Machida, Keinosuke Okamoto, Tomoe Negishi, Sachiko Kimura, Toshinori Suzuki, Tsutomu Hatano, Sakae Arimoto-Kobayashi

JOURNAL OF PHOTOCHEMISTRY AND PHOTOBIOLOGY A-CHEMISTRY, 276 1-7, Feb, 2014
Effects of oral administration of non-genotoxic hepato-hypertrophic compounds on metabolic potency of rat liver

Xing Fang, Tatsuo Nunoshiba, Midori Yoshida, Akiyoshi Nishikawa, Kiyomitsu Nemoto, Masakuni Degawa, Sakae Arimoto, Keinosuke Okamoto, Eizo Takahashi, Tomoe Negishi

Genes and Environment, 36(1) 1-9, 2014

Misc.

環境及び医薬品混在物の光変異原性―重合開始剤の光変異原性

有元佐賀惠, 市原英則, 高井真理子, 河崎陽一, 北村佳久, 千堂年昭

日本光医学・光生物学会, 38th 26, 2016
注射薬中から検出された重合開始剤の光変異原性に関する研究

高井真理子, 河崎陽一, 谷本雄亮, 江角悟, 有元佐賀惠, 根岸友惠, 北村佳久, 北村佳久, 千堂年昭, 千堂年昭

日本環境変異原学会大会プログラム・要旨集, 44th 107, Nov 24, 2015
P-045 Effects of photo irradiation on the mutagenicity of sidestream smoke of cigarette(Poster Sessions)

Ichihara Hidenori, Negishi Tomoe, Arimoto Sakae

(44) 115-115, 2015
P-061 Inhibitory effect of vinegar-extract of A. arguta on 1,2-dimethylhydrazine induced colon preneoplastic lesion in male F344 rat(Poster Sessions)

Arimoto Sakae, Miyake Naoko, Tada Misako, Negishi Tomoe

(44) 123-123, 2015
RXR partial agonist produced by side-chain repositioning of alkoxy RXR full agonist retains anti-type 2 diabetes activity without the adverse effects

Kawata, K, Morishita, K, Yamada, S, Nakayama, M, Kobayashi, T, Furusawa, Y, Arimoto-Kobayashi, S, Oohashi, T, Makishima, M, Naitou, H …

Journal of Medicinal Chemistry, 58(2) 912-926, Jan, 2015 Peer-reviewed
P-066 Antimutagenicity of A. arguta and its mechanisms(Poster Sessions)

Tadaa Misako, Miyake Naoko, Okimasu Yuma, Nishimura Mari, Negishi Tomoe, Arimoto-Kobayashi Sakae

(43) 123-123, 2014
P-067 Modifying effects of Actinidia arguta and its components on 1,2-dimethyl-hydrazine induced colon preneoplastic lesions in male F344 rats(Poster Sessions)

Miyake Naoko, Tada Misako, Okimasu Yuma, Nishimura Mari, Asahi Chiharu, Hida Ryoko, Negishi Tomoe, Arimoto-Kobayashi Sakae

(43) 124-124, 2014
O-13 Somatic cell mutations caused by 365-nm LED-UVA(Platform Session 3)

Fan Xing, Arimoto-Kobayashi Sakae, Toyooka Tatsushi, Ibuki Yuko, Zhao Xiaoxu, Suzuki Toshinori, Negishi Tomoe

(43) 87-87, 2014
長波長紫外線によるDNA傷害と体細胞突然変異

樊星, 有元佐賀惠, 岡本敬の介, 豊岡達士, 伊吹裕子, 根岸友惠

日本薬学会年会要旨集(CD-ROM), 134th, 2014
長波長紫外線(365nm-UVA)の変異誘発傷害とその修復機構

樊星, 有元佐賀惠, 豊岡達士, 伊吹裕子, 亀井保博, 根岸友恵

日本光医学・光生物学会, 36th, 2014
長波長紫外線(365nm-UVA)の変異誘発傷害とその修復機構

FAN Xing, 有元佐賀惠, 豊岡達士, 伊吹裕子, ZHAO Xiaoxu, 鈴木利典, 根岸友惠

日本環境変異原学会大会プログラム・要旨集, 43rd, 2014
注射薬中から検出された重合開始剤の変異原性に関する研究

高井真理子, 河崎陽一, 谷本雄亮, 江角悟, 有元佐賀惠, 北村佳久, 千堂年昭

日本環境変異原学会大会プログラム・要旨集, 42nd 99, Oct 30, 2013
注射薬中から検出された重合開始剤の変異原性に関する研究

高井真理子, 河崎陽一, 谷本雄亮, 江角悟, 有元佐賀惠, 北村佳久, 千堂年昭

日本医療薬学会年会講演要旨集, 23rd 286, Aug 28, 2013
Analysis of Carboxy Terminal Domain of Metalloprotease of Elastolytic Aeromonas hydrophila

Takahashi Eizo, Kobayashi Hidetomo, Yamanaka Hiroyasu, Nakanishi Mayu, Tateishi Arisa, Abe Takemi, Arimoto Sakae, Negishi Tomoe, Okamoto Keinosuke

Biological and Pharmaceutical Bulletin, 36(7) 1174-1182, 2013
サルナシの抗発癌・抗炎症機能性

有元佐賀恵, 沖増侑磨, 西村麻里

ニューフードインダストリー, 54(10) 29-36, Oct, 2012
P-069 Purification of Antimutagenic Component(s) in the Juice of Actinidia arguta and it's Preventive Effects on Carcinogenesis(V. Antimutagenicity,Poster Presentation)

Okimasu Yuma, Nishimura Mari, Okamoto Keinosuke, Negishi Tomoe, Arimoto-Kobayashi Sakae

(41) 125-125, 2012
Anti-genotoxic activity of Vitis coignetiae Pulliat towards heterocyclic amines and isolation and identification of caftaric acid as an antimutagenic component from the juice

Zhang X, Ishida R, Yuhara Y, Kamiya T, Hatano T, Okamoto G, Arimoto-Kobayashi S

Mutation Research, 723(2) 182-189, 2011
P-103 Isolation and identification of an antimutagenic component in the juice of Vitis coignetiae Pulliat which prevents skin tumor promotion in mice(Poster Presentation)

Arimoto-Kobayashi Sakae, Zhang Xiaomeng, Ishida Rie, Yuhara Yuta, Kamiya Tomonori, Hatano Tsutomu, Negishi Tomoe, Okamoto Goro

(39) 144-144, 2010
P-037 Mutagenesis induced by nimustine, an anticancer nitrosourea derivative(DNA damages,Poster Session)

Yamada Yoko, Okamoto Keinosuke, Arimoto Sakae, Takahashi Eizo, Negishi Tomoe

(38) 119-119, 2009
Hypersensitivity of a Urate-null Strain of Drosophila melanogaster to the Toxic Effects of Environmental Cigarette Smoke

Yuko Hamatake, Ayumi Morita, Yoko Yuma, Keinosuke Okamoto, Sakae Arimoto, Toshinori Suzuki, Hiroshi Kasai, Kazuaki Kawai, Tomoe Negishi

Genes and Environment, 31(2) 43-46, 2009

Books and Other Publications

Beer in ‘Chemoprevention of Cancer and DNA Damage by Dietary Factors’

Metka Filipic, Janja Plazar, Sakae Arimoto-Kobayashi

2009 (ISBN: 9783527320585)
Beer in Health and Disease Prevention (共著）

Academic Press, 2008
Inhibitory effects of beer and other alcoholic beverages on the mutagenesis and DNA-adduct formations induced by several carcinogens: identification of one of the antimutagenic factors. Dietary Anticarcinogens and Antimutagens, Chemical and Biological Aspects

2000
Inhibitory activity of natural chlorophylls on the mutagenicity of 4-nitroquinoline-1-oxide and 3-amino-1-methyl-5H-pyrido[4,3-b]indole in Drosophila. Food Factors for Cancer Prevention

1997
血液の抗変異原物質｢抗変異･抗発癌物質とその検索法｣

有元佐賀惠

講談社サイエンティフィク, 1995
Dietary inhibitors against mutagenesis and carcinogenesis. Basic life Sciences, 61, Antimutagenesis and Anticarcinogenesis Mechanisms III

1993
Methods for separation and detection of heterocyclic amines. Mutagens in Food: Detection and Prevention

1991
化学と生物実験ライン３変異原物質試験法

有元佐賀惠, 根岸友恵, 早津彦哉, 別所忠昌, 益谷美都子 (Role: Joint author)

広川書店, 1990
Inhibition of the genotoxicity of 3-amino-1-methyl-5H-pyrido[4,3-b]indole (Trp-P-2) in Drosophila by chlorophyll. Basic life Sciences, 52, Antimutagenesis and Anticarcinogenesis Mechanisms II

1990
Problems in monitoring mutagenicity of human urine. Methods for Detecting DNA Damaging Agents in Humans: Applications in Cancer Epidemiology and Prevention

1988
Antimutagenic activity in extracts of human feces. Carcinogens and Mutagens in the Environment, Vol. 2: Naturally Occurring Compounds

1983

Works

知恵の見本市

2014
第1９回岡山リサーチパーク研究・展示発表会

2014

Research Projects

Survay on carcinogenic risks by oral bacteria and their measures

Grants-in-Aid for Scientific Research, Grant-in-Aid for Scientific Research (C), Japan Society for the Promotion of Science, Apr, 2019 - Mar, 2022

Kokeguchi Susumu
Analysis of photochemical activation of endogenic and environmental N-nitrosamines and its photogenotoxicity and disturbance on cell functions

Grants-in-Aid for Scientific Research, Grant-in-Aid for Scientific Research (C), Japan Society for the Promotion of Science, Apr, 2015 - Mar, 2019

Arimoto Sakae, Negishi Tomoe
UVA activated N-nitrosoproline induced damages on DNA, protein and membrane, and disturbance of signal transduction

Grants-in-Aid for Scientific Research, Grant-in-Aid for Scientific Research (C), Japan Society for the Promotion of Science, 2011 - 2013

ARIMOTO Sakae
塩蔵食品由来変異原2-クロロ-4-メチルチオ酪酸によるDNA損傷に関する研究

科学研究費助成事業, 基盤研究(C), 日本学術振興会, 2009 - 2011

木村幸子, 有元佐賀惠
DNA and protein modification and disturbance on cell system with NO produced from photo-reactivation of N-nitrosated amino acids

Grants-in-Aid for Scientific Research, Grant-in-Aid for Scientific Research (C), Japan Society for the Promotion of Science, 2008 - 2010

ARIMOTO Sakae, KIMURA Sachiko
Reaction mechanisms and evaluation of toxicity of the formation of nitric oxide from UVA-irradiated N-nitroso-compound

Grants-in-Aid for Scientific Research, Grant-in-Aid for Scientific Research (C), Japan Society for the Promotion of Science, 2003 - 2005

ARIMOTO Sakae, OKAMOTO Keinosuke, NEGASHI Tomoe, KIMURA Sachiko

Media Coverage

ヤマブドウ果汁でマウス肺癌予防

東京メトロポリタンテレビジョン株式会社（TOKYO MX）, 医師専門サイト「MedPeer」内「MEDICAL NEWS LINE」, Jul 12, 2021 Internet
ヤマブドウ果汁に肺がん抑える効果マウス実験で確認

山陽新聞, Jul 5, 2021 Newspaper, magazine
サルナシ茶に前癌病変予防効果産地の新庄村「特産化に弾み」

山陽新聞, Aug 21, 2017 Newspaper, magazine
サルナシの魅力発信

福島民友, Jul 31, 2017 Newspaper, magazine
サルナシに放射線の障害抑制効果

OHK, みんなのニュース, Sep 9, 2016 TV or radio program
サルナシに放射線障害抑制効果岡山大大学院・有元准教授が確認

山陽新聞, Aug 22, 2016 Newspaper, magazine
サルナシに放射線の障害抑制効果

真庭タイムス, Aug 10, 2016 Newspaper, magazine
「岡山県「サルナシ」新庄村で取れるキウイの別種 ”サルナシ”に肺がんを抑える働きがあると動物実験で実証」「岡山県「ヤマブドウ」高濃度のポリフェノールが含まれるヤマブドウは皮膚がんの発症と炎症を抑える」

(株)エイチアンドエス, 健康365, Jun 16, 2016 Newspaper, magazine
新庄で特産サルナシ研究成果講演岡山大准教授が発がん抑制報告

山陽新聞, Jul 31, 2015 Newspaper, magazine
胃がん予防に新手法

夕刊フジ, May 30, 2015 Newspaper, magazine
ピロリ菌、遺伝子変異誘発岡山大発表、薬剤開発に期待

産經新聞, Apr 26, 2015 Newspaper, magazine
ピロリ菌が遺伝子変異を誘発岡山大、胃がん防止に光

日本経済新聞, Apr 24, 2015 Newspaper, magazine
新庄サルナシ人気

山陽新聞, Jan 23, 2015 Newspaper, magazine
サルナシ肺がん抑制効果

山陽新聞, Aug 6, 2014
大腸の前癌病変抑制

山陽新聞, Aug 25, 2013 Newspaper, magazine
ヤマブドウの果汁でマウス皮膚ガン予防

科学新聞, Jun 7, 2013 Newspaper, magazine
ヤマブドウ果汁皮膚がんを抑制

山陽新聞, Jun 4, 2013 Newspaper, magazine
ヤマブドウに皮膚がん抑制効果

毎日新聞, May 24, 2013 Newspaper, magazine
サルナシに皮膚がん抑制効果

山陽新聞, Sep 17, 2012 Newspaper, magazine
「付加価値向上へ研究」「産官学連携で健康成分など新商品目指す」

山陽新聞, Aug 4, 2010 Newspaper, magazine

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