2005年12月
HF10, an attenuated herpes simplex virus (HSV) type 1 clone, lacks neuroinvasiveness and protects mice against lethal challenge with HSV types 1 and 2
MICROBES AND INFECTION
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- 巻
- 7
- 号
- 15
- 開始ページ
- 1492
- 終了ページ
- 1500
- 記述言語
- 英語
- 掲載種別
- DOI
- 10.1016/j.micinf.2005.05.007
- 出版者・発行元
- ELSEVIER SCIENCE BV
Herpes simplex virus (HSV), a neurotropic virus, establishes life-long and, although rare, life-threatening infection in humans, and it may precipitate substantial medical and psychosocial morbidity. Here we show that HSV-1 strain HF clone 10 (HF 10) exhibits impaired neuroinvasiveness in peripheral olfactory, vomeronasal and trigeminal conduits following intranasal as well as corneal inoculation. HF10 attenuation likely arises from multiple defects of HSV genes, so that HF10 will not revert to a virulent phenotype. Intranasal vaccination of mice with HF 10 conferred significant protection against lethal challenge with HSV-1 and HSV-2 via the intranasal and intravaginal routes. Thus, we propose that HF10 explicitly meets the prerequisites for a candidate live attenuated HSV vaccine. (C) 2005 Elsevier SAS. All rights reserved.
- リンク情報
- ID情報
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- DOI : 10.1016/j.micinf.2005.05.007
- ISSN : 1286-4579
- Web of Science ID : WOS:000234466800005