1998年3月
High-turnover osteopenia in preterm infants: Determination of urinary pyridinium cross-links of collagen
METABOLISM-CLINICAL AND EXPERIMENTAL
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- 巻
- 47
- 号
- 3
- 開始ページ
- 333
- 終了ページ
- 335
- 記述言語
- 英語
- 掲載種別
- 研究論文(学術雑誌)
- 出版者・発行元
- W B SAUNDERS CO
Osteopenia is a frequent condition in preterm infants, but its pathogenesis is uncertain. In the present study, we measured longitudinal changes in the excretion of pyridinium cross-links of collagen (specific markers of bone resorption) and evaluated the relationship between collagen cross-links and other indexes of bone and renal function in preterm infants. In these infants, urinary collagen cross-links were markedly increased on day 7 and day 30 of life and at estimated full-term gestation. The values were several times higher than those of older children and almost comparable to those of healthy full-term infants. Cross-link excretion did not correlate with beta(2)-microglobulin (B2M) or N-acetyl-beta-D-glucosaminidase (NAG) activity (markers of renal function), indicating that cross-link excretion is not influenced directly by infantile renal function. High serum osteocalcin and low bone mineral density (BMD) in the lumbar spine were also observed at estimated full-term gestation, There was no significant correlation between collagen cross-link excretion and either serum osteocalcin or spine BMD. We conclude that a state of high bone turnover underlies the development of osteopenia in preterm infants. Copyright (C) 1998 by W.B. Saunders Company.
- リンク情報
- ID情報
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- ISSN : 0026-0495
- Web of Science ID : WOS:000072329700016