1995年6月
ATRIAL-NATRIURETIC-PEPTIDE AND ANTIHYPERTENSIVE ACTION DUE TO BETA-BLOCKADE IN ESSENTIAL HYPERTENSIVE PATIENTS
ANGIOLOGY
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- 巻
- 46
- 号
- 6
- 開始ページ
- 511
- 終了ページ
- 516
- 記述言語
- 英語
- 掲載種別
- 出版者・発行元
- WESTMINSTER PUBL INC
The effects of beta-blocker treatment on hemodynamics were studied in relation to plasma atrial natriuretic peptide (ANP) levels in 17 outpatients with essential hypertension. Administration of propranolol for twelve weeks to untreated subjects resulted in a significant (P < 0.001) rise in plasma ANP levels (from 37.9 +/- 21.2 to 66.7 +/- 46.2 pg/mL, mean +/- SD). Systolic and diastolic blood pressures were significantly decreased (P < 0.05 and P < 0.01, respectively). Heart rate was also significantly decreased (P < 0.001). On the other hand, a significant reduction of cardiac index was detected (from 4.12 +/- 1.34 to 2.96 +/- 0.75 L/min/m(2), P < 0.01) with chronic administration of propranolol, suggesting a reflection of decreased cardiac function. A significant negative correlation was observed between %changes in systolic blood pressure and %changes in plasma ANP (r=-0.594, P < 0.05). These results suggest that the increased plasma ANP levels may contribute to the antihypertensive effect with propranolol.
- リンク情報
- ID情報
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- ISSN : 0003-3197
- Web of Science ID : WOS:A1995RD29100008