福石信之 (Nobuyuki Fukuishi) - マイポータル

基本情報

所属: 金城学院大学薬学部薬学科基礎医療薬学分野薬理学研究室教授

学位: 薬学修士(大阪薬科大学)
博士(薬学)(徳島文理大学)

J-GLOBAL ID: 200901048239073906
researchmap会員ID: 1000115841

研究キーワード

研究分野

経歴

2015年4月 - 現在

金城学院大学, 薬学部, 教授
2007年

- 徳島文理大学薬学部准教授
2003年 - 2006年

徳島文理大学薬学部助教授
2001年 - 2003年

米国NIH研究員
2001年 - 2003年

LAD/NIAID/NIH. Visiting Fellow
2003年

Pharmaceutical Sciences,
1998年 - 2001年

徳島文理大学薬学部助教授
1998年 - 2001年

Pharmaceutical Sciences,
1992年 - 1998年

徳島文理大学薬学部助手
1992年 - 1998年

Pharmaceutical sciences, Tokushima Bunri
1988年 - 1992年

中外製薬株式会社研究員
1988年 - 1992年

Chugai Pharmaceutical Co., Ltd. Research
Associate Professor
徳島文理大学
University, Research Assistant
associate

学歴

委員歴

日本薬理学会, 評議員

受賞

論文

1O, 20O-diacetyl kamebakaurin protects against acetaminophen-induced hepatotoxicity in mice.

Hiroki Yoshioka, Tsunemasa Nonogaki, Hiroyuki Ohnishi, Nobuyuki Fukuishi, Masae Yoshikawa, Ming-Yu Gui, Yong-Ri Jin, Xu-Wen Li, Yoshiyuki Adachi, Naohito Ohno …

Biomedical research (Tokyo, Japan) 39(5) 251-260 2018年査読有り
Suppressive effect of kamebakaurin on acetaminophen-induced hepatotoxicity by inhibiting lipid peroxidation and inflammatory response in mice.

Hiroki Yoshioka, Yutaka Aoyagi, Nobuyuki Fukuishi, Ming-Yu Gui, Yong-Ri Jin, Xu-Wen Li, Yoshiyuki Adachi, Naohito Ohno, Koichi Takeya, Yukio Hitotsuyanagi …

Pharmacological reports : PR 69(5) 903-907 2017年10月査読有り
Chronotoxicity of bromobenzene-induced hepatic injury in mice

Hiroki Yoshioka, Tsunemasa Nonogaki, Nobuyuki Fukuishi, Yasuro Shinohara, Gi-Wook Hwang, Katsumi Ohtani, Nobuhiko Miura

JOURNAL OF TOXICOLOGICAL SCIENCES 42(2) 251-258 2017年4月査読有り
Vitamin D3-induced hypercalcemia increases carbon tetrachloride-induced hepatotoxicity through elevated oxidative stress in mice

Hiroki Yoshioka, Haruki Usuda, Nobuhiko Miura, Nobuyuki Fukuishi, Tsunemasa Nonogaki, Satomi Onosaka

PLOS ONE 12(4) e0176524 2017年4月査読有り
Bromobenzene-induced lethal toxicity in mouse is prevented by pretreatment with zinc sulfate

Hiroki Yoshioka, Shiori Fukaya, Nobuyuki Fukuishi, Akito Nagatsu, Tsunemasa Nonogaki, Satomi Onosaka

CHEMICO-BIOLOGICAL INTERACTIONS 254 117-123 2016年7月査読有り
Carbon Tetrachloride-Induced Nephrotoxicity in Mice Is Prevented by Pretreatment with Zinc Sulfate

Hiroki Yoshioka, Haruki Usuda, Nobuyuki Fukuishi, Tsunemasa Nonogaki, Satomi Onosaka

BIOLOGICAL & PHARMACEUTICAL BULLETIN 39(6) 1042-1046 2016年6月査読有り
Calcium-deficient diet attenuates carbon tetrachloride-induced hepatotoxicity in mice through suppression of lipid peroxidation and inflammatory response

Hiroki Yoshioka, Tsunemasa Nonogaki, Nobuyuki Fukuishi, Satomi Onosaka

Heliyon 2(6) e00126 2016年6月1日査読有り
Compound 48/80, a Mast Cell Stimulator, Enhances Synthesis of IgE and IgG Induced by Intranasal Application of Ovalbumin in Mice

Nobuaki Matsui, Daisuke Ito, Yukari Takabatake, Eri Nashioka, Shingo Tada, Masato Kanagawa, Nobuyuki Fukuishi, Masaaki Akagi

BIOLOGICAL & PHARMACEUTICAL BULLETIN 38(12) 1954-1959 2015年12月査読有り
CD72 negatively regulates mouse mast cell functions and down-regulates the expression of KIT and FcεRIα.

Kataoka TR, Kumanogoh A, Fukuishi N, Ueshima C, Hirata M, Moriyoshi K, Tsuruyama T, Haga H

International immunology 27(2) 95-103 2015年2月査読有り
Nonpeptide neurotrophic agents useful in the treatment of neurodegenerative diseases such as Alzheimer's disease

Masaaki Akagi, Nobuaki Matsui, Haruka Akae, Nana Hirashima, Nobuyuki Fukuishi, Yoshiyasu Fukuyama, Reiko Akagi

JOURNAL OF PHARMACOLOGICAL SCIENCES 127(2) 155-163 2015年2月査読有り
Does β-hexosaminidase function only as a degranulation indicator in mast cells? The primary role of β-hexosaminidase in mast cell granules.

Fukuishi N, Murakami S, Ohno A, Yamanaka N, Matsui N, Fukutsuji K, Yamada S, Itoh K, Akagi M

Journal of immunology (Baltimore, Md. : 1950) 193(4) 1886-1894 2014年8月査読有り
Generation of Mast Cells from Mouse Fetus: Analysis of Differentiation and Functionality, and Transcriptome Profiling Using Next Generation Sequencer

Nobuyuki Fukuishi, Yuusuke Igawa, Tomoyo Kunimi, Hirofumi Hamano, Masao Toyota, Hironobu Takahashi, Hiromichi Kenmoku, Yasuyuki Yagi, Nobuaki Matsui, Masaaki Akagi

PLOS ONE 8(4) e60837 2013年4月査読有り
Phenylbutenoid dimers isolated from Zingiber purpureum exert neurotrophic effects on cultured neurons and enhance hippocampal neurogenesis in olfactory bulbectomized mice

Nobuaki Matsui, Yuki Kido, Hideki Okada, Miwa Kubo, Megumi Nakai, Nobuyuki Fukuishi, Yoshiyasu Fukuyama, Masaaki Akagi

NEUROSCIENCE LETTERS 513(1) 72-77 2012年3月査読有り
Magnolol and honokiol prevent learning and memory impairment and cholinergic deficit in SAMP8 mice

Nobuaki Matsui, Kazuki Takahashi, Miho Takeichi, Touma Kuroshita, Kaori Noguchi, Kana Yamazaki, Hideaki Tagashira, Kenichi Tsutsui, Hideki Okada, Yuki Kido …

BRAIN RESEARCH 1305 108-117 2009年12月査読有り
Lipoteichoic acid improves the capability of mast cells in the host defense system against bacteria

Naoki Imajo, Daisuke Kurihara, Nobuyuki Fukuishi, Asumi Inukai, Shinobu Matsushita, Shingo Noda, Mako Toyoda, Mino Yoshioka, Hayato Teruya, Yumiko Nishii …

INFLAMMATION RESEARCH 58(11) 797-807 2009年11月査読有り
Human mast cells synthesize and release angiogenin, a member of the ribonuclease A (RNase A) superfamily

Marianna Kulka, Nobuyuki Fukuishi, Dean D. Metcalfe

JOURNAL OF LEUKOCYTE BIOLOGY 86(5) 1217-1226 2009年11月査読有り
The protective effect of H-2-receptor activation against the duration of myocardial hypoxia/reoxygenation-induced ventricular fibrillation in sensitized guinea-pig hearts

N Imajo, S Matsui, Y Yasui, N Matsui, N Fukuishi, M Akagi

JOURNAL OF PHARMACOLOGICAL SCIENCES 99(4) 400-407 2005年12月査読有り
Enzymatic measurement of tryptase-like protease release from isolated perfused guinea pig heart during ischemia-reperfusion

N Matsui, T Okikawa, N Imajo, Y Yasui, N Fukushi, M Akagi

BIOLOGICAL & PHARMACEUTICAL BULLETIN 28(11) 2149-2151 2005年11月査読有り
Neurotrophic effect of magnolol in the hippocampal CA1 region of senescence-accelerated mice (SAMP1)

N Matsui, H Nakashima, Y Ushio, T Tada, T Shirono, Y Fukuyama, K Nakade, HF Zhai, Y Yasui, N Fukushi …

BIOLOGICAL & PHARMACEUTICAL BULLETIN 28(9) 1762-1765 2005年9月査読有り
Protective effect of the 5-lipoxygenase inhibitor ardisiaquinone A on hepatic ischemia-reperfusion injury in rats

N Matsui, N Fukuishi, Y Fukuyama, Y Yasui, M Akagi

PLANTA MEDICA 71(8) 717-720 2005年8月査読有り

もっとみる

MISC

Human cathelicidin CAP18/LL-37 changes mast cell function toward innate immunity.

Yoshioka M, Fukuishi N, Kubo Y, Yamanobe H, Ohsaki K, Kawasoe Y, Murata M, Ishizumi A, Nishii Y, Matsui N …

Biol Pharm Bull 31(2) 212-216 2008年
Lipoteichoic acid downregulates FC epsilon RI expression on human mast cells through Toll-like receptor 2

Mino Yoshioka, Nobuyuki Fukuishi, Sayuri Iriguchi, Kanae Ohsaki, Hiroyuki Yamanobe, Asumi Inukai, Daisuke Kurihara, Naoki Imajo, Yumiko Yasui, Nobuaki Matsui …

JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY 120(2) 452-461 2007年8月
Heme oxygenase-1 inhibits cytokine production by activated mast cells

Yumiko Yasui, Mao Nakamura, Toshihiro Onda, Tomohiro Uehara, Saori Murata, Nobuaki Matsui, Nobuyuki Fukuishi, Reiko Akagi, Makoto Suematsu, Masaaki Akagi

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS 354(2) 485-490 2007年3月
Bacterial components regulate the expression of toll-like receptor 4 on human mast cells

Y. Kubo, N. Fukuishi, M. Yoshioka, Y. Kawasoe, S. Iriguchi, N. Imajo, Y. Yasui, N. Matsui, M. Akagi

INFLAMMATION RESEARCH 56(2) 70-75 2007年2月
Upregulation of heme oxygenase-1 by degranulation in rat basophilic leukemia cells.

Yasui Y, Sasao E, Sakata M, Matsui N, Fukuishi N, Akagi R, Akagi M

Biol Pharm Bull. 30(3) 443-446 2007年
Mast cells, which interact with Escherichia coli, up-regulate genes associated with innate immunity and become less responsive to Fc epsilon RI-mediated activation

Marianna Kulka, Nobuyuki Fukuishi, Menachem Rottem, Yoseph A. Mekori, Dean D. Metcalfe

JOURNAL OF LEUKOCYTE BIOLOGY 79(2) 339-350 2006年2月
The role of mast cells in allergic inflammation--from the view point of innate immune system involvement

Fukuishi N, Yoshioka M, Akagi M

Nippon Yakurigaku Zasshi 125(5) 259-264 2005年
Sounding the Alarm in Infection -Mast cell Counter-Attack

Journal of the World Allergy Organization 6(2) 2004年
Identification of Fyn-binding proteins in MC/9 mast cells using mass spectrometry

DH Nahm, C Tkaczyk, N Fukuishi, E Colucci-Guyon, AM Gilfillan, DD Metcalfe

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS 310(1) 202-208 2003年10月
Inhibitory effect of KW-4679 on the infiltration of eosinophils in the nasal mucosa of rat allergic rhinitis models

AKAGI M.

Jpn Pharmacol Ther 29(3) 187-191 2001年
Xanthine oxidase(XOD)-derived reactive oxygen species(ROS)activate NF-kappa B after ischemia-reperfusion in rat liver

The Japanese Journal of Pharmacology 84(3) 363-366 2000年
Novel action of quinolones on osteoclast-like cells

Nobuyuki Fukuishi, Nobuaki Matsui, Reiko Kanoh, Masaaki Akagi

Journal of Toxicological Sciences 24(5) 383-391 1999年
Novel action of quinolones on osteoclast-like cells

Nobuyuki Fukuishi, Nobuaki Matsui, Reiko Kanoh, Masaaki Akagi

Journal of Toxicological Sciences 24(5) 383-391 1999年
Physiological function, types, and mode of existence of superoxide dismutase in rat peritoneal mast cells.

Archives of Pharmacology 352(2) 734 1998年
Examination of ultraviolet iraddiation-indused injury in mice skin. (共著)

Jpn. J. Pharmacol. 76(1) 161 1997年
Inhibitor effect of apafant on bronchopulmonary responses to platelet activating factor and to antigen in rats. (共著)

Drug Research 47(12) 1364 1997年
Anti-allergic effect of tea-leaf saponin(TLS)from tea leaves (Camellia sinensis ver sinensis)

Masaaki AKAGI, Nobuyuki FUKUISHI, Tomoko KAN, Yuko M. SAGESAKA, Reiko AKAGI

Phamaceutical society of Japan, Biological and pharmaceutical bulletin 20(5) 565-567 1997年
The mechanisms of compound 48/80-induced superoxide generation mediated by A-Kinase in rat peritoneal mast cellls

Academic press, Biochemical and molecular medicine 61(1) 107-113 1997年
Inhibitory effect of epinastine on superoxide generation by rat neutrophils

Jpn. J. Pharmacol 68(4) 449-452 1995年
Contribution of platelet activating factor (PAF) in histamine-induced model of nasal allergy in rats

M. Akagi, R. Kanoh, N. Fukuishi, M. Tachibana, R. Akagi

Japanese Journal of Allergology 44(3 I) 182-188 1995年

もっとみる

書籍等出版物

ラット肝虚血-再灌流モデルにおけるNF-KBの活性化

腎とフリーラジカル第5集 2000年
NF-Kappa B Activation on ischemia-reperfusion model of Rat Liver.

2000年

所属学協会

Works(作品等)

共同研究・競争的資金等の研究課題

マスト細胞の生理的役割に関する研究

共同研究 2002年 - 2010年
Mast cell biology

Cooperative Research 2002年 - 2010年
肥満細胞と自然免疫

2000年
局所免疫機構の破綻が原因で引き起こされる疾病に関する研究
Research on the sickness caused by insufficiency of the local immune system
The relationship between the role of mast cell and innate immunity