2019年10月8日
Iridium-Catalyzed C(sp3)−H Addition of Methyl Ethers across Intramolecular Carbon–Carbon Double Bonds Giving 2,3-Dihydrobenzofurans
Advanced Synthesis and Catalysis
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- 巻
- 361
- 号
- 19
- 開始ページ
- 4448
- 終了ページ
- 4453
- 記述言語
- 英語
- 掲載種別
- 研究論文(学術雑誌)
- DOI
- 10.1002/adsc.201900749
Intramolecular addition of an O-methyl C(sp )−H bond across a carbon-carbon double bond occurs in the iridium-catalyzed reaction of methyl 2-(propen-2-yl)phenyl ethers. The Ir/(S)-DTBM-SEGPHOS catalyst promotes the reaction efficiently in toluene at 110–135 °C to afford 3,3-dimethyl-2,3-dihydrobenzofurans. Enantioselective C(sp )−H addition is achieved in the reaction of methyl 2-(1-siloxyethenyl)phenyl ethers, affording enantioenriched 3-hydroxy-2,3-dihydrobenzofuran derivatives with up to 96% ee. (Figure presented.). 3 3
- リンク情報
- ID情報
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- DOI : 10.1002/adsc.201900749
- ISSN : 1615-4150
- eISSN : 1615-4169
- SCOPUS ID : 85072112406