1991年11月
INCREASE OF METHYLGUANIDINE AND GUANIDINOACETIC ACID IN THE BRAIN OF AMYGDALA-KINDLED RATS
EPILEPSIA
- ,
- ,
- 巻
- 32
- 号
- 6
- 開始ページ
- 761
- 終了ページ
- 766
- 記述言語
- 英語
- 掲載種別
- 出版者・発行元
- LIPPINCOTT-RAVEN PUBL
Guanidino compounds are intrinsic chemoconvulsants. We investigated the regional and time-dependent changes of these compounds in the amygdala (AM) of kindled rats versus electroconvulsive shock (ECS) seizures using high-performance liquid chromatography (HPLC). Twenty-eight days after the last AM-kindled seizure, guanidinoacetic acid (GAA) and methylguanidine (MG) levels were significantly increased in the bilateral AM as compared with those of control rats, which had been implanted with electrodes but were not stimulated. Both compounds, however, tended to decrease in the bilateral AM after ECS seizure. In addition, we measured these compounds after induction of one afterdischarge AD) in the AM. These compounds increased significantly 7 days after AD was induced in the ipsilateral AM. We suggest that the increase of these compounds is coincident with AD generation and specific to AM kindling and the kindled state.
- リンク情報
- ID情報
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- ISSN : 0013-9580
- Web of Science ID : WOS:A1991GU51700003