Eriko Simamura

Profile Information

Affiliation: Senior Assistant Professor, School of Medicine, Department of Molecular and Cell Structural Science (Anatomy Ⅰ), Kanazawa Medical University

Degree: PhD(Kochi Medical School)
家政学修士(お茶の水女子大学)
PhD
博士（医学）

J-GLOBAL ID: 200901044932844481
researchmap Member ID: 1000196253

External link: http://www.kanazawa-med.ac.jp/~anatomyl/

Research Interests

Research History

Apr, 2008

Assistant professor, Kanazawa medical University
Apr, 1994 - Mar, 2008

Kanazawa Medical University
1994 - 2008

School of Medicine, Kanazawa Medical University
2008

- 金沢医科大学医学部, 講師

Education

- 1994

Ochanomizu University
- 1992

Faculty of Home Economics, Ochanomizu University

Awards

Papers

Significance of sugar chain recognition by galectins and its involvement in diseases-associated glycosylation

Congenital Anomalies, 54(2):77-81., Jan, 2014
Significance of sugar chain recognition by galectins and its involvement in disease-associated glycosylation

T.Arikawa, E.Simamura, H.Shimada, T.Nakamura, T.Hatta, H.Shoji

Congenital anomalies, 54:77-81, 2014
Expression pattern of Galectin 4 in rat placentation

Tomohiro Arikawa, Eriko Simamura, Hiroki Shimada, Nozomu Nishi, Takanori Tatsuno, Yasuhito Ishigaki, Naohisa Tomosugi, Chizu Yamashiro, Toshiyuki Hata, Tsutomu Takegami …

Placenta, 2012 Aug 6. [Epub ahead of pri, Aug, 2012
Expression pattern of Galectin 4 in rat placentation

T.Arikawa, E.Shimamura, H.Shimada, N.Nishi, T.Tatsuno, Y.Ishigaki, N.Tomosugi, C.Yamashiro, T.Hata, T.Takegami …

Placenta, 33:885-887, Jul, 2012
Effects of melanocortins on fetal development

E.Simamura, H.Shimada, H.Shoji, H.Otani, T.Hatta

Congenital anomalies, 51:47-54, 2011
Maternal leukemia inhibitory factor (LIF) promotes fetal neurogenesis via a LIF-ACTH-LIF signaling relay pathway

E.Simamura, H.Shimada, N.Higashi, M.Uchishiba, H.Otani, T.Hatta

Endocrinology., 151:1853-1862, Apr, 2010
Branching patterns of the celiac artery as the hepato-gastro-splenic trunk

N.Higashi, H.Shimada, E.Simamura, T.Hatta

Acta anatomica Nipponica, 84:7-10(1) 7-10, Mar, 2009
Paraquat toxicity induced by voltage-dependent anion channel 1 acts as an NADH-dependent oxidoreductase

H.Shimada, K-I.Hirai, E.Simamura, T.Hatta, H.Iwakiri, K.Mizuki, T.Hatta, T.Sawasaki, S.Matsunaga, Y.Endo …

The Journal of biological chemistry., 284: 28642-28649, 2009
Mitochondrial voltage-dependent anion channels (VDACs) as novel pharmacological targets for anti-cancer agents

E.Simamura, H.Shimada, T.Hatta, K-I.Hirai

Journal of bioenergetics and biomembranes., 40:213-217, Sep, 2008
Bioreductive activation of quinone antitumor drugs by mitochondrial voltage-dependent anion channel 1

E.Simamura, H.Shimada, Y.Ishigaki, T.Hatta, N.Higashi, K-I.Hirai

Anatomical science international / Japanese Association of Anatomists, 83:261-266, Aug, 2008
Right vertebral artery as the fourth branch of the aortic arch

N.Higashi, H.Shimada, E.Simamura, T.Hatta

Anatomical science international / Japanese Association of Anatomists, 83:314-318, Aug, 2008
Mouse exo utero development system

T.Hatta, M.Yamada, E.Simamura, H.Shimada, M.Nimura, A.Matsumoto, J.Udagawa, R.Hashimoto, N.Higashi, H.Otani

32:16-22, Jun, 2007
Antiallergic activity of aqueous extracts and constituents of Taxus yunnanensis.

J.Koyama, I.Morita, N.Kobayashi, K.-I.Hirai, E.Simamura, T.Nobukawa, S.Kadota

Biological & pharmaceutical bulletin, 29:2310-2312, Nov, 2006
Furanonaphthoquinones cause apoptosis of cancer cells by inducing the production of reactive oxygen species by the mitochondrial voltage-dependent anion channel

E.Simamura, K.-I.Hirai, H.Shimada, J.Koyama, Y.Niwa, S.Shimizu

Cancer biology & therapy, 5:1523-1529, Nov, 2006
Growth inhibitory activity of wood of Taxus yunnanensis and its liquid chromatography fourier-transform mass spectrometry analysis

JY.Ueda, S.Awale, Y.Tezuka, E.Simamura, K.-I.Hirai, T.Nobukawa, A.Sato, S.Kadota

Planta medica, 72:1241-1244, Jan, 2006
The mechanisms of anti-cancer activity by the natural constituents of Taxus yunnanensis

K.Ikai, E.Simamura, K-I.Hirai

31:165-171, Jan, 2006
タキサス天然成分タキサン化合物による腫瘍細胞増殖抑制と Apoptosis 誘導

30:531-534, Dec, 2005
The synthetic furanonaphthoquinone induces growth arrest, apoptosis and differentiation in a variety of leukaemias and multiple myeloma cells

J.C.Desmond, H.Kawabata, C.Mueller-Tidow, E.Simamura, D.Heber, K.Hirai, H.P.Koeffler

British journal of haematology., 131:520-529, 2005
Scientist His Imperial Highness Prince Hitachi in Kanazawa

1-44, Jan, 2005
The participation of mitochondrial membrane permeable protein in mitochondrial damage by an anticancer agent furanonaphthoquinone

E. Simamura, H. Shimada, K.-I. Hirai

8th Asia-Pacific Conference on Electron Microscopy,2004, PROC.:1274-1275, 2004

Misc.

Significance of sugar chain recognition by galectins and its involvement in disease- associated glycosylation

Tomohiro Arikawa, Eriko Simamura, Hiroki Shimada, Takanori Nakamura, Toshihisa Hatta, Hiroki Shoji

CONGENITAL ANOMALIES, 54(2) 77-81, May, 2014
Expression pattern of Galectin 4 in rat placentation

T. Arikawa, E. Simamura, H. Shimada, N. Nishi, T. Tatsuno, Y. Ishigaki, N. Tomosugi, C. Yamashiro, T. Hata, T. Takegami …

PLACENTA, 33(10) 885-887, Oct, 2012
Effects of melanocortins on fetal development

Eriko Simamura, Hiroki Shimada, Hiroki Shoji, Hiroki Otani, Toshihisa Hatta

CONGENITAL ANOMALIES, 51(2) 47-54, Jun, 2011
Effects of melanocortins on fetal development

Eriko Simamura, Hiroki Shimada, Hiroki Shoji, Hiroki Otani, Toshihisa Hatta

CONGENITAL ANOMALIES, 51(2) 47-54, Jun, 2011
Maternal Leukemia Inhibitory Factor (LIF) Promotes Fetal Neurogenesis via a LIF-ACTH-LIF Signaling Relay Pathway

Eriko Simamura, Hiroki Shimada, Nobuaki Higashi, Maimi Uchishiba, Hiroki Otani, Toshihisa Hatta

ENDOCRINOLOGY, 151(4) 1853-1862, Apr, 2010
Maternal Leukemia Inhibitory Factor (LIF) Promotes Fetal Neurogenesis via a LIF-ACTH-LIF Signaling Relay Pathway

Eriko Simamura, Hiroki Shimada, Nobuaki Higashi, Maimi Uchishiba, Hiroki Otani, Toshihisa Hatta

ENDOCRINOLOGY, 151(4) 1853-1862, Apr, 2010
Paraquat Toxicity Induced by Voltage-dependent Anion Channel 1 Acts as an NADH-dependent Oxidoreductase

Hiroki Shimada, Kei-Ichi Hirai, Eriko Simamura, Toshihisa Hatta, Hiroki Iwakiri, Keiji Mizuki, Taizo Hatta, Tatsuya Sawasaki, Satoko Matsunaga, Yaeta Endo …

JOURNAL OF BIOLOGICAL CHEMISTRY, 284(42) 28642-28649, Oct, 2009
Paraquat Toxicity Induced by Voltage-dependent Anion Channel 1 Acts as an NADH-dependent Oxidoreductase

Hiroki Shimada, Kei-Ichi Hirai, Eriko Simamura, Toshihisa Hatta, Hiroki Iwakiri, Keiji Mizuki, Taizo Hatta, Tatsuya Sawasaki, Satoko Matsunaga, Yaeta Endo …

JOURNAL OF BIOLOGICAL CHEMISTRY, 284(42) 28642-28649, Oct, 2009
Branching patterns of the celiac artery as the hepato-gastro-splenic trunk

N.Higashi, H.Shimada, E.Simamura, T.Hatta

Acta Anatomica Nipponica., 84 7-10, 2009
左胃動脈、脾動脈、総肝動脈が共同幹をなす腹腔動脈の分枝様式

東伸明, 島田ひろき, 島村英理子, 八田稔久

解剖誌, 84 7-10, 2009
Right vertebral artery as the fourth branch of the aortic arch

Nobuaki Higashi, Hiroki Shimada, Eriko Simamura, Toshihisa Hatta

ANATOMICAL SCIENCE INTERNATIONAL, 83(4) 314-318, Dec, 2008
Bioreductive activation of quinone antitumor drugs by mitochondrial voltage-dependent anion channel 1

Eriko Simamura, Hiroki Shimada, Yasuhito Ishigaki, Toshihisa Hatta, Nobuaki Higashi, Kei-Ichi Hirai

ANATOMICAL SCIENCE INTERNATIONAL, 83(4) 261-266, Dec, 2008
Right vertebral artery as the fourth branch of the aortic arch

Nobuaki Higashi, Hiroki Shimada, Eriko Simamura, Toshihisa Hatta

ANATOMICAL SCIENCE INTERNATIONAL, 83(4) 314-318, Dec, 2008
Bioreductive activation of quinone antitumor drugs by mitochondrial voltage-dependent anion channel 1

Eriko Simamura, Hiroki Shimada, Yasuhito Ishigaki, Toshihisa Hatta, Nobuaki Higashi, Kei-Ichi Hirai

ANATOMICAL SCIENCE INTERNATIONAL, 83(4) 261-266, Dec, 2008
Mitochondrial voltage-dependent anion channels (VDACs) as novel pharmacological targets for anti-cancer agents

Eriko Simamura, Hiroki Shimada, Toshihisa Hatta, Kei-Ichi Hirai

JOURNAL OF BIOENERGETICS AND BIOMEMBRANES, 40(3) 213-217, Jun, 2008
Mitochondrial voltage-dependent anion channels (VDACs) as novel pharmacological targets for anti-cancer agents

Eriko Simamura, Hiroki Shimada, Toshihisa Hatta, Kei-Ichi Hirai

JOURNAL OF BIOENERGETICS AND BIOMEMBRANES, 40(3) 213-217, Jun, 2008
Mouse exo utero development system

T.Hatta, M.Yamada, E.Simamura, H.Shimada, M.Nimura, A.Matsumoto, J.Udagawa, R.Hashimoto, N.Higashi, H.Otani

J. Kanazawa. Med. Univ., 32 16-22, 2007
マウス胎児子宮外発生法

八田稔久, 山田真紀子, 島村英理子, 島田ひろき, 二村正行, 松本暁洋, 宇田川潤, 橋本龍樹, 東伸明, 大谷浩

金医大誌, 32 16-22, 2007
Furanonaphthoquinones cause apoptosis of cancer cells by inducing the production of reactive oxygen species by the mitochondrial voltage-dependent anion channel

Eriko Simamura, Kei-Ichi Hirai, Hiroki Shimada, Junko Koyama, Yukie Niwa, Shigeomi Shimizu

CANCER BIOLOGY & THERAPY, 5(11) 1523-1529, Nov, 2006
Furanonaphthoquinones cause apoptosis of cancer cells by inducing the production of reactive oxygen species by the mitochondrial voltage-dependent anion channel

Eriko Simamura, Kei-Ichi Hirai, Hiroki Shimada, Junko Koyama, Yukie Niwa, Shigeomi Shimizu

CANCER BIOLOGY & THERAPY, 5(11) 1523-1529, Nov, 2006

Books and Other Publications

南米・アマゾン原産のハーブ・スパイス

Jan, 2006
Proceedings of the 8th Asia-Pacific Conference on Electron Microscopy in conjunction with the 60th Annual Meeting of the Japanese Society of Microscopy

Nobuo Tanaka, Yoshiro Takano, Hirotaro Mori, Harumichi Seguchi, Shoichi Iseki, Hiroki Shimada, Eriko Simamura

8APEM Publication Committee, Jun, 2004

Presentations

130

Voltage dependent anion channels as molecular targets for furanonaphthoquinone antitumor compounds

E.Simamura, K.-I.Hirai, H.Shimada, J.Koyama, S.Shimizu

International Conference on Mitochondria and Life 2005, Dec, 2005
VDAC protein is responsible for paraquat cytotoxicity

H.Shimada, K.-I.Hirai, E.Simamura, S.Shimizu

International Conference on Mitochondrial and life 2005, Dec, 2005
フラノナフトキノン誘導体によるミトコンドリアでの活性酸素生成とアポトーシス誘導

Jun, 2005
パラコート毒性を引き起こすミトコンドリア局在酵素による活性酸素生成の蛍光プローブを用いた解析

Jun, 2005
VDACを介して活性酸素を生成する抗腫瘍性物質フラノナフトキノン誘導体の分子機構

Jun, 2005
紅豆杉天然成分による癌細胞増殖抑制とApoptosis誘導

Mar, 2005
VDAC1 siRNAを用いたフラノナフトキノン誘導体の作用機序の検討

癌分子標的研究会, 2005
紅豆杉天然成分による癌細胞増殖抑制とアポトーシス誘導

Jan, 2005
VDAC高発現癌を標的とする抗癌性天然化学物質によるマイルドな補完的治療の可能性

Jan, 2005
パラコート毒性を引き起こすミトコンドリア酵素NADH-quinone oxidoreductasemの解析

日本解剖学会第65回中部支部学術集会, 2005
Defense of UV-induced cell death by antioxidants

K. Furuta, K.-I. Hirai, H. Shimada, E. Simamura

8th Asia-Pacific Conference on Electron Microscopy,2004, 2004
The participation of voltage dependent anion channel (VDAC) protein in NADH-quinone oxidoreductasem activity on paraquat cytotoxicity

H. Shimada, K.-I. Hirai, E. Simamura

8th Asia-Pacific Conference on Electron Microscopy,2004, 2004
The participation of mitochondrial membrane permeable protein in mitochondrial damage by an anticancer agent furanonaphthoquinone

E. Simamura, H. Shimada, K.-I. Hirai

8th Asia-pacific conference on electron microscopy,2004, 2004
ミトコンドリア膜透過性蛋白によるフラノナフトキノン誘導体の活性酸素生成

第４回日本ミトコンドリア研究会年会, 2004
Furanonaphthoquinone誘導体による癌細胞内活性酸素生成局在

2003
心筋内カルシウムイオン分布のエネルギーフィルター型透過電子顕微鏡的研究

2003
パラコートのミトコンドリア毒性に関与する膜透過性タンパク質の蛍光画像解析

2003
パラコートのミトコンドリア障害に対するミトコンドリア膜透過性蛋白の関与

2003
ミトコンドリア外膜の活性酸素生成系：化学物質による細胞毒性機構

第13回体力・栄養・免疫学会, 2003
中国雲南省の紅豆杉天然成分によるがん細胞増殖抑制とアポトーシス誘導

第41回日本癌治療学会総会・学術集会, 2003

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