2003年9月
Splicing isoform of SYT-SSX fusion protein accelerates transcriptional activity and cell proliferation
CANCER LETTERS
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- 巻
- 199
- 号
- 1
- 開始ページ
- 35
- 終了ページ
- 43
- 記述言語
- 英語
- 掲載種別
- DOI
- 10.1016/S0304-3835(03)00314-8
- 出版者・発行元
- ELSEVIER SCI IRELAND LTD
The human SYT-SSX gene has two splicing isoforms (type N and 1), the latter of which contains an additional insertion of 93 bases. In the present study, we found increased transcriptional activity of the SYT-SSX type I protein in luciferase assay. When the SYT-SSX cDNAs were transfected to NIH3T3 cells, the type I transformant grew faster than the type N transformant. Furthermore, we evaluated the isoform ratio of the SYT or SYT-SSX transcripts in various tissues. Our results suggest that the SYT-SSX type I protein plays a critical role in the tumorigenesis of synovial sarcomas through increased transcriptional activity. (C) 2003 Elsevier Ireland Ltd. All rights reserved.
- リンク情報
- ID情報
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- DOI : 10.1016/S0304-3835(03)00314-8
- ISSN : 0304-3835
- Web of Science ID : WOS:000185528200005