2001年
Novel liver macromolecular MR contrast agent with a polypropylenimine diaminobutyl dendrimer core: Comparison to the vascular MR contrast agent with the polyamidoamine dendrimer core
Magnetic Resonance in Medicine
- 巻
- 46
- 号
- 4
- 開始ページ
- 795
- 終了ページ
- 802
- 記述言語
- 英語
- 掲載種別
- 研究論文(学術雑誌)
- DOI
- 10.1002/mrm.1259
As MRI contrast agents, more hydrophobic molecules reportedly accumulate in the liver and thus are potentially useful as liver MRI contrast agents. In this study, a generation-4 polypropylenimine diaminobutane dendrimer (DAB-Am64), which is expected to be more hydrophobic than the generation-4 polyamidoamine dendrimer (PAMAM-G4D), was used to synthesize a conjugate with 2-(p-isothiocyanatobenzyl)-6-methyl-diethylenetriaminepentaacetic acid (1B4M) [DAB-Am64- (1B4M-Gd)64] for complexing Gd(III) ions. This DAB conjugate quickly accumulated in the liver and its characteristics were studied and compared with those of a PAMAM conjugate [PAMAM-G4D(1B4M-Gd)64], which is known to be a useful vascular MRI contrast agent, in regard to its availability as a liver MRI contrast agent. DAB-Am64-(1B4M-Gd)64 accumulated significantly more in the liver and less in blood than PAMAM-G4D-(1B4M-Gd)64 (P <
0.001). Contrast-enhanced MRI with DAB-Am64-(1B4MGd)64 was able to homogeneously enhance liver parenchyma and visualize both portal and hepatic veins of 0.5 mm diameter in mice. In conclusion, DAB-Am64-(1B4M-Gd)64 is a good candidate for a liver MRI contrast agent. © 2001 Wiley-Liss, Inc.
0.001). Contrast-enhanced MRI with DAB-Am64-(1B4MGd)64 was able to homogeneously enhance liver parenchyma and visualize both portal and hepatic veins of 0.5 mm diameter in mice. In conclusion, DAB-Am64-(1B4M-Gd)64 is a good candidate for a liver MRI contrast agent. © 2001 Wiley-Liss, Inc.
- ID情報
-
- DOI : 10.1002/mrm.1259
- ISSN : 0740-3194
- PubMed ID : 11590657
- SCOPUS ID : 0034794601