2004年
5-Aryl-1,3,4-oxadiazole-2-thiols as a new series of trans-cinnamate 4-hydroxylase inhibitors
JOURNAL OF PESTICIDE SCIENCE
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- 巻
- 29
- 号
- 3
- 開始ページ
- 205
- 終了ページ
- 208
- 記述言語
- 英語
- 掲載種別
- DOI
- 10.1584/jpestics.29.205
- 出版者・発行元
- PESTICIDE SCI SOC JAPAN
A series of 5-aryl-1,3,4-oxadiazole-2-thiols was found to inhibit trans-cinnamate 4-hydroxylase (C4H) from Populus kitakamiensis, which was expressed in yeast. 5-Phenyl-1,3,4-oxadiazole-2-thiol showed inhibitory activity comparable to 2-hydroxy-1-naphthoic acid, a known C4H inhibitor. Studies on the structure-activity relationship indicated that the presence of a thiol group was significant for stronger activity. Of the compounds tested, 5-(3-fluorophenyl)-1,3,4-oxadiazole-2-thiol was the most active. (C) Pesticide Science Society of Japan.
- リンク情報
- ID情報
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- DOI : 10.1584/jpestics.29.205
- ISSN : 1348-589X
- Web of Science ID : WOS:000224508100006