2018年2月15日
Gas-phase study of hydrogen-bonding interaction in clusters of biological molecules using IR spectroscopy
Spectroscopy and Dynamics of Molecules and Clusters
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回数 : 207
- 記述言語
- 英語
- 会議種別
- 口頭発表（招待・特別）
- 主催者
- SMDC2018
- 開催地
- Dooars, India
The technique of laser-desorption/supersonic jet is employed to isolate nucleic acid components in the gas phase, and their hydrogen (H)-bonded structures are investigated by mass-selected IR spectroscopy and theoretical calculation. It is shown that in base pairs of guanine-guanine and guanine-cytosine, energetically most stable structures are observed and hydration occurs without affecting the base pairing.
H-bonding behavior of uric acid, the final product of purine catabolism, is also studied in terms of hydration and complexation with melamine, a non-biological molecule that is related to the accumulation of urinary stones in infants. Based on IR spectroscopic measurements, it is demonstrated that the two H-bond structures are similar, with the same H-bonding sites involved in both hydrates and complexes with melamine.
The technique of laser-desorption/supersonic jet is employed to isolate nucleic acid components in the gas phase, and their hydrogen (H)-bonded structures are investigated by mass-selected IR spectroscopy and theoretical calculation. It is shown that in base pairs of guanine-guanine and guanine-cytosine, energetically most stable structures are observed and hydration occurs without affecting the base pairing.
H-bonding behavior of uric acid, the final product of purine catabolism, is also studied in terms of hydration and complexation with melamine, a non-biological molecule that is related to the accumulation of urinary stones in infants. Based on IR spectroscopic measurements, it is demonstrated that the two H-bond structures are similar, with the same H-bonding sites involved in both hydrates and complexes with melamine.
H-bonding behavior of uric acid, the final product of purine catabolism, is also studied in terms of hydration and complexation with melamine, a non-biological molecule that is related to the accumulation of urinary stones in infants. Based on IR spectroscopic measurements, it is demonstrated that the two H-bond structures are similar, with the same H-bonding sites involved in both hydrates and complexes with melamine.
The technique of laser-desorption/supersonic jet is employed to isolate nucleic acid components in the gas phase, and their hydrogen (H)-bonded structures are investigated by mass-selected IR spectroscopy and theoretical calculation. It is shown that in base pairs of guanine-guanine and guanine-cytosine, energetically most stable structures are observed and hydration occurs without affecting the base pairing.
H-bonding behavior of uric acid, the final product of purine catabolism, is also studied in terms of hydration and complexation with melamine, a non-biological molecule that is related to the accumulation of urinary stones in infants. Based on IR spectroscopic measurements, it is demonstrated that the two H-bond structures are similar, with the same H-bonding sites involved in both hydrates and complexes with melamine.