1997年9月
A novel form of the myeloid-specific zinc finger protein (MZF-2)
GENES TO CELLS
- ,
- ,
- 巻
- 2
- 号
- 9
- 開始ページ
- 581
- 終了ページ
- 591
- 記述言語
- 英語
- 掲載種別
- 研究論文(学術雑誌)
- DOI
- 10.1046/j.1365-2443.1997.1430341.x
- 出版者・発行元
- BLACKWELL SCIENCE LTD
Background: Myeloid cell development is controlled by tissue-specific transcription factors, Human myeloid zinc finger protein (MZF-1) is a putative transcription factor containing 13 zinc fingers, and has been suggested that it regulates the development of neutrophilic granulocytes,
Results: Here, we have isolated the murine and human cDNAs which encode a novel form of MZF protein (MZF-2), Murine and human MZF-2 proteins consisted of 814 and 775 amino acids, respectively, and have identity of 75.3% between them, The C-terminal half of human MZF-2, carrying the zinc finger domains, was completely identical with that of human MZF-1, whereas the N-terminal half of MZF-2 was different from the corresponding region of human MZF-1, and was coded by distinct exons, MZF-2 mRNA was expressed in myeloid cells, particularly in the cells committed to the neutrophilic lineage, and down-regulated by G-CSE
Conclusions: MZF-1 and MZF-2 mRNAs seem to be produced by the alternative use of two different transcription initiation sites, The distinct N-terminal half of MZF-2 carries two characteristic domains, a leucine-rich domain called LeR and an acidic domain, which suggests a unique function of MZF-2 in neutrophil development.
Results: Here, we have isolated the murine and human cDNAs which encode a novel form of MZF protein (MZF-2), Murine and human MZF-2 proteins consisted of 814 and 775 amino acids, respectively, and have identity of 75.3% between them, The C-terminal half of human MZF-2, carrying the zinc finger domains, was completely identical with that of human MZF-1, whereas the N-terminal half of MZF-2 was different from the corresponding region of human MZF-1, and was coded by distinct exons, MZF-2 mRNA was expressed in myeloid cells, particularly in the cells committed to the neutrophilic lineage, and down-regulated by G-CSE
Conclusions: MZF-1 and MZF-2 mRNAs seem to be produced by the alternative use of two different transcription initiation sites, The distinct N-terminal half of MZF-2 carries two characteristic domains, a leucine-rich domain called LeR and an acidic domain, which suggests a unique function of MZF-2 in neutrophil development.
- リンク情報
- ID情報
-
- DOI : 10.1046/j.1365-2443.1997.1430341.x
- ISSN : 1356-9597
- Web of Science ID : WOS:A1997YG63700005