Kazuo Fujihara

Profile Information

J-GLOBAL ID: 200901014912462934
researchmap Member ID: 1000247675

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Research Areas

Research History

Professor, Tohoku University Graduate School of Medicine, Department of Multiple Sclerosis Therapeutics

Committee Memberships

Papers

144

Patterns of regional brain volume loss in multiple sclerosis: a cluster analysis.

Juichi Fujimori, Kazuo Fujihara, Ryo Ogawa, Toru Baba, Mike Wattjes, Ichiro Nakashima

Journal of neurology, 267(2) 395-405, Feb, 2020 Peer-reviewed
Trial of Satralizumab in Neuromyelitis Optica Spectrum Disorder.

Yamamura T, Kleiter I, Fujihara K, Palace J, Greenberg B, Zakrzewska-Pniewska B, Patti F, Tsai CP, Saiz A, Yamazaki H …

The New England journal of medicine, 381(22) 2114-2124, Nov, 2019 Peer-reviewed
Inebilizumab for the treatment of neuromyelitis optica spectrum disorder (N-MOmentum): a double-blind, randomised placebo-controlled phase 2/3 trial.

Cree BAC, Bennett JL, Kim HJ, Weinshenker BG, Pittock SJ, Wingerchuk DM, Fujihara K, Paul F, Cutter GR, Marignier R …

Lancet (London, England), 394(10206) 1352-1363, Oct, 2019 Peer-reviewed
Long-term outcome of a group of Japanese children with myelin-oligodendrocyte glycoprotein encephalomyelitis without preventive immunosuppressive therapy.

Naomi Hino-Fukuyo, Kazuhiro Haginoya, Toshiyuki Takahashi, Ichiro Nakashima, Kazuo Fujihara, Yoshiki Takai, Manami Akasaka, Shigeo Kure

Brain & development, 41(9) 790-795, Oct, 2019 Peer-reviewed
Two Japanese cases of anti-MOG antibody-associated encephalitis that mimicked neuro-Behçet's disease.

Juichi Fujimori, Toshiyuki Takahashi, Yuki Matsumoto, Kazuo Fujihara, Yoshiki Takai, Tatsuro Misu, Ichiro Nakashima

Journal of neuroimmunology, 334 577002-577002, Sep 15, 2019 Peer-reviewed
Eculizumab in Aquaporin-4-Positive Neuromyelitis Optica Spectrum Disorder.

Sean J Pittock, Achim Berthele, Kazuo Fujihara, Ho Jin Kim, Michael Levy, Jacqueline Palace, Ichiro Nakashima, Murat Terzi, Natalia Totolyan, Shanthi Viswanathan …

The New England journal of medicine, 381(7) 614-625, Aug 15, 2019 Peer-reviewed
Myelin oligodendrocyte glycoprotein (MOG) antibody-associated disease: practical considerations.

Juryńczyk M, Jacob A, Fujihara K, Palace J

Practical neurology, 19(3) 187-195, Jun, 2019 Peer-reviewed
Neuromyelitis optica spectrum disorders: still evolving and broadening.

Fujihara K

Current opinion in neurology, 32(3) 385-394, Jun, 2019 Peer-reviewed
Outcome prediction models in AQP4-IgG positive neuromyelitis optica spectrum disorders.

Jacqueline Palace, Dan-Yu Lin, Donglin Zeng, Masoud Majed, Liene Elsone, Shahd Hamid, Silvia Messina, Tatsuro Misu, Jessica Sagen, Daniel Whittam …

Brain : a journal of neurology, 142(5) 1310-1323, May 1, 2019 Peer-reviewed
Circulating AQP4-specific auto-antibodies alone can induce neuromyelitis optica spectrum disorder in the rat.

Sophie Hillebrand, Kathrin Schanda, Magdalini Nigritinou, Irina Tsymala, Denise Böhm, Patrick Peschl, Yoshiki Takai, Kazuo Fujihara, Ichiro Nakashima, Tatsuro Misu …

Acta neuropathologica, 137(3) 467-485, Mar, 2019 Peer-reviewed
Area postrema syndrome: Frequency, criteria, and severity in AQP4-IgG-positive NMOSD.

Eslam Shosha, Divyanshu Dubey, Jacqueline Palace, Ichiro Nakashima, Anu Jacob, Kazuo Fujihara, Toshiyuki Takahashi, Daniel Whittam, Maria Isabel Leite, Tatsuro Misu …

Neurology, 91(17) e1642-e1651-e1651, Oct 23, 2018 Peer-reviewed
Transient Pulmonary Interstitial Lesions in Aquaporin-4-positive Neuromyelitis Optica Spectrum Disorder.

Asato Y, Kamitani T, Ootsuka K, Kuramochi M, Nakanishi K, Shimada T, Takahashi T, Misu T, Aoki M, Fujihara K …

Internal medicine (Tokyo, Japan), 57(20) 2981-2986, Oct, 2018 Peer-reviewed
CSF cytokine profile in MOG-IgG+ neurological disease is similar to AQP4-IgG+ NMOSD but distinct from MS: A cross-sectional study and potential therapeutic implications

Kimihiko Kaneko, Douglas Kazutoshi Sato, Ichiro Nakashima, Ryo Ogawa, Tetsuya Akaishi, Yoshiki Takai, Shuhei Nishiyama, Toshiyuki Takahashi, Tatsuro Misu, Hiroshi Kuroda …

Journal of Neurology, Neurosurgery and Psychiatry, 89(9) 927-936, Jun 5, 2018 Peer-reviewed
Nationwide epidemiological study of neuromyelitis optica in Japan.

Miyamoto K, Fujihara K, Kira JI, Kuriyama N, Matsui M, Tamakoshi A, Kusunoki S

Journal of neurology, neurosurgery, and psychiatry, 89(6) 667-668, Jun, 2018 Peer-reviewed
MOG-IgG-associated optic neuritis, encephalitis, and myelitis: Lessons learned from neuromyelitis optica spectrum disorder

Giordani Rodrigues dos Passos, Luana Michelli Oliveira, Bruna Klein da Costa, Samira Luisa Apostolos-Pereira, Dagoberto Callegaro, Kazuo Fujihara, Douglas Kazutoshi Sato

Frontiers in Neurology, 9 217, Apr 4, 2018 Peer-reviewed
Children with myelin oligodendrocyte glycoprotein antibodies-associated disease: relation of phenotypes to central nervous system myelin maturation

Hiroshi Kuroda, Kazuo Fujihara

Developmental Medicine and Child Neurology, 60(4) 339-340, Apr 1, 2018 Peer-reviewed
Diagnosis of multiple sclerosis: 2017 revisions of the McDonald criteria

Alan J Thompson, Brenda L Banwell, Frederik Barkhof, William M Carroll, Timothy Coetzee, Giancarlo Comi, Jorge Correale, Franz Fazekas, Massimo Filippi, Mark S Freedman …

The Lancet Neurology, 17(2) 162-173, Feb 1, 2018 Peer-reviewed
Severe aquaporin 4-IgG-positive neuromyelitis optica with disseminated herpes zoster in a pregnant woman successfully treated with intravenous immunoglobulin.

Matsumoto Y, Tsuchiya M, Norshalena S, Kaneko C, Kubo J, Yamamoto T, Takahashi T, Fujihara K

Multiple sclerosis journal - experimental, translational and clinical, 4(1) 2055217318758119-2055217318758119, Jan, 2018 Peer-reviewed
Fingolimod-associated PML with mild IRIS in MS: A clinicopathologic study.

Shuhei Nishiyama, Tatsuro Misu, Yukiko Shishido-Hara, Kazuo Nakamichi, Masayuki Saijo, Yoshiki Takai, Kentarou Takei, Naoki Yamamoto, Hiroshi Kuroda, Ryuta Saito …

Neurology(R) neuroimmunology & neuroinflammation, 5(1) e415, Jan, 2018 Peer-reviewed
Cognitive impairment in neuromyelitis optica spectrum disorders: A comparison of the Wechsler Adult Intelligence Scale-III and the Wechsler Memory Scale Revised with the Rao Brief Repeatable Neuropsychological Battery.

Juichi Fujimori, Ichiro Nakashima, Toru Baba, Yuko Meguro, Ryo Ogawa, Kazuo Fujihara

eNeurologicalSci, 9 3-7, Dec, 2017 Peer-reviewed

Misc.

Modulation of dendritic cell development by immunoglobulin G in control subjects and multiple sclerosis patients

K. Ohkuma, T. Sasaki, S. Kamei, S. Okuda, H. Nakano, T. Hamamoto, K. Fujihara, I. Nakashima, T. Misu, Y. Itoyama

CLINICAL AND EXPERIMENTAL IMMUNOLOGY, 150(3) 397-406, Dec, 2007
Modulation of dendritic cell development by immunoglobulin G in control subjects and multiple sclerosis patients

K. Ohkuma, T. Sasaki, S. Kamei, S. Okuda, H. Nakano, T. Hamamoto, K. Fujihara, I. Nakashima, T. Misu, Y. Itoyama

CLINICAL AND EXPERIMENTAL IMMUNOLOGY, 150(3) 397-406, Dec, 2007
Two different clinical phenotypes of Creutzfeldt-Jakob disease with a M232R substitution

Yusei Shiga, Katsuya Satoh, Tetsuyuki Kitamoto, Sigenori Kanno, Ichiro Nakashima, Shigeru Sato, Kazuo Fujihara, Hiroshi Takata, Keigo Nobukuni, Shigetoshi Kuroda …

JOURNAL OF NEUROLOGY, 254(11) 1509-1517, Nov, 2007
Two different clinical phenotypes of Creutzfeldt-Jakob disease with a M232R substitution

Yusei Shiga, Katsuya Satoh, Tetsuyuki Kitamoto, Sigenori Kanno, Ichiro Nakashima, Shigeru Sato, Kazuo Fujihara, Hiroshi Takata, Keigo Nobukuni, Shigetoshi Kuroda …

JOURNAL OF NEUROLOGY, 254(11) 1509-1517, Nov, 2007
Low-dose corticosteroids reduce relapses in neuromyelitis optica: a retrospective analysis

S. Watanabe, T. Misu, I. Miyozawa, I. Nakashima, Y. Shiga, K. Fujihara, Y. Itoyama

MULTIPLE SCLEROSIS, 13(8) 968-974, Sep, 2007
Low-dose corticosteroids reduce relapses in neuromyelitis optica: a retrospective analysis

S. Watanabe, T. Misu, I. Miyozawa, I. Nakashima, Y. Shiga, K. Fujihara, Y. Itoyama

MULTIPLE SCLEROSIS, 13(8) 968-974, Sep, 2007
Alteration of cystatin C in the cerebrospinal fluid of multiple sclerosis

Ichiro Nakashima, Masakatsu Fujinoki, Kazuo Fujihara, Takeshi Kawamura, Toshihide Nishimura, Masashi Nakamura, Yasuto Itoyama

ANNALS OF NEUROLOGY, 62(2) 197-200, Aug, 2007
Alteration of cystatin C in the cerebrospinal fluid of multiple sclerosis

Ichiro Nakashima, Masakatsu Fujinoki, Kazuo Fujihara, Takeshi Kawamura, Toshihide Nishimura, Masashi Nakamura, Yasuto Itoyama

ANNALS OF NEUROLOGY, 62(2) 197-200, Aug, 2007
Anti-aquaporin-4 antibody is involved in the pathogenesis of NMO: a study on antibody titre

Takahashi, Toshiyuki, Fujihara, Kazuo, Nakashima, Ichiro, Misu, Tatsuro, Miyazawa, Isabelle, Nakamura, Masashi, Watanabe, Shohei, Shiga, Yusei, Kanaoka, Chihiro, Fujimori, Juichi …

BRAIN, 130(Pt 5) 1235-1243, May, 2007
Loss of aquaporin 4 in lesions of neuromyelitis optica: distinction from multiple sclerosis

T. Misu, K. Fujihara, A. Kakita, H. Konno, M. Nakamura, S. Watanabe, T. Takahashi, I. Nakashima, H. Takahashi, Y. Itoyama

BRAIN, 130(Pt 5) 1224-1234, May, 2007
Successful treatment of a hypothalamic lesion in neuromyelitis optica by plasma exchange

Shohei Watanabe, Ichiro Nakashima, Isabelle Miyazawa, Tatsuro Misu, Yusei Shiga, Yoichi Nakagawa, Kazuo Fujihara, Yasuto Itoyama

JOURNAL OF NEUROLOGY, 254(5) 670-671, May, 2007
Anti-aquaporin-4 antibody is involved in the pathogenesis of NMO: a study on antibody titre

Takahashi, Toshiyuki, Fujihara, Kazuo, Nakashima, Ichiro, Misu, Tatsuro, Miyazawa, Isabelle, Nakamura, Masashi, Watanabe, Shohei, Shiga, Yusei, Kanaoka, Chihiro, Fujimori, Juichi …

BRAIN, 130(Pt 5) 1235-1243, May, 2007
Loss of aquaporin 4 in lesions of neuromyelitis optica: distinction from multiple sclerosis

T. Misu, K. Fujihara, A. Kakita, H. Konno, M. Nakamura, S. Watanabe, T. Takahashi, I. Nakashima, H. Takahashi, Y. Itoyama

BRAIN, 130(Pt 5) 1224-1234, May, 2007
Successful treatment of a hypothalamic lesion in neuromyelitis optica by plasma exchange

Shohei Watanabe, Ichiro Nakashima, Isabelle Miyazawa, Tatsuro Misu, Yusei Shiga, Yoichi Nakagawa, Kazuo Fujihara, Yasuto Itoyama

JOURNAL OF NEUROLOGY, 254(5) 670-671, May, 2007
Clinical and laboratory features of neuromyelitis optica with oligoclonal IgG bands

M. Nakamura, I. Nakashima, S. Sato, I. Miyazawa, K. Fujihara, Y. Itoyama

MULTIPLE SCLEROSIS, 13(3) 332-335, Apr, 2007
Two subtypes of optic-spinal form of multiple sclerosis in Japan: clinical and laboratory features

Ichiro Nakashima, Toshiyuki Fukazawa, Kohei Ota, Chiyoko Nohara, Yoko Warabi, Takashi Ohashi, Isabelle Miyazawa, Kazuo Fujihara, Yasuto Itoyama

JOURNAL OF NEUROLOGY, 254(4) 488-492, Apr, 2007
Clinical and laboratory features of neuromyelitis optica with oligoclonal IgG bands

M. Nakamura, I. Nakashima, S. Sato, I. Miyazawa, K. Fujihara, Y. Itoyama

MULTIPLE SCLEROSIS, 13(3) 332-335, Apr, 2007
Two subtypes of optic-spinal form of multiple sclerosis in Japan: clinical and laboratory features

Ichiro Nakashima, Toshiyuki Fukazawa, Kohei Ota, Chiyoko Nohara, Yoko Warabi, Takashi Ohashi, Isabelle Miyazawa, Kazuo Fujihara, Yasuto Itoyama

JOURNAL OF NEUROLOGY, 254(4) 488-492, Apr, 2007
High CSF neurofilament heavy chain levels in neuromyelitis optica

I. Miyazawa, I. Nakashima, A. Petzold, K. Fujihara, S. Sato, Y. Itoyama

NEUROLOGY, 68(11) 865-867, Mar, 2007
High CSF neurofilament heavy chain levels in neuromyelitis optica

I. Miyazawa, I. Nakashima, A. Petzold, K. Fujihara, S. Sato, Y. Itoyama

NEUROLOGY, 68(11) 865-867, Mar, 2007

Presentations

NMO, MS and Plasmapheresis in Japan

第11回世界アフェレシス学会, 2007
NMO, MS and Plasmapheresis in Japan

第11回世界アフェレシス学会, 2007
視神経脊髄炎(NMO)の疾患概念、病態と治療

第48回日本神経学会総会, 2007
Recent advances in anti-AQP4 antibody research

MS Forum the 4th Consensus Group Meeting, 2007
Is there a role for plasmapheresis and low-dose corticosteroids in NMO

MS Forum the 4th Consensus Group Meeting, 2007
多発性硬化症(MS)と視神経脊髄炎(NMO)-髄液抗体及びタンパクからみた病態の違い-

第17回日本臨床検査専門医会春季大会, 2007
多発性硬化症の病態と治療：診療へのアプローチ

第25回日本神経治療学会, 2007
MSにおけるステロイド療法の意義

第6回MSワークショップ, 2007
Neuromyelitis opticaとaquaporin-4：診断と病態における意義

第6回東京MS研究会, 2007
Neuromyelitis optica and OSMS: the Japanese Experience

Seminar Series on Neuroimmunological Diseases, 2007
Neuromyelitis optica and optic-spinal MS: The Japanese experience

5th MS Forum Pan-Asian Conference, 2007
視神経脊髄炎(Neuromyelitis Optica)：抗aquaporin-4抗体の発見とその疾患概念及び病態への意義

第28回日本アフェレシス学会学術大会, 2007
Neuromyelitis Optica：その疾患概念、病態と治療抗aquaporin-4抗体の発見とその疾患概念及び病態への意義

第45回日本神経眼科学会総会, 2007
NMO, MS and Plasmapheresis in Japan

第11回世界アフェレシス学会, 2007
NMO, MS and Plasmapheresis in Japan

第11回世界アフェレシス学会, 2007
視神経脊髄炎(NMO)の疾患概念、病態と治療

第48回日本神経学会総会, 2007
Recent advances in anti-AQP4 antibody research

MS Forum the 4th Consensus Group Meeting, 2007
Is there a role for plasmapheresis and low-dose corticosteroids in NMO

MS Forum the 4th Consensus Group Meeting, 2007
多発性硬化症(MS)と視神経脊髄炎(NMO)-髄液抗体及びタンパクからみた病態の違い-

第17回日本臨床検査専門医会春季大会, 2007
多発性硬化症の病態と治療：診療へのアプローチ

第25回日本神経治療学会, 2007

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Misc.

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