1996
Chemical and etiological studies on tetrodotoxin and its analogs
JOURNAL OF TOXICOLOGY-TOXIN REVIEWS
- ,
- Volume
- 15
- Number
- 2
- First page
- 81
- Last page
- 90
- Language
- English
- Publishing type
- Research paper (scientific journal)
- Publisher
- MARCEL DEKKER INC
The marked fluctuation of tetrodotoxin (TTX) contents in pufferfish led us to suspect the exogenous origin of the toxin. Based on a food chain hypothesis, various marine biota were tested for TTX with a fluorometric tetrodotoxin analyzer. Consequently, bacteria were found to be the genetic origin of TT. The survey also revealed the occurrence of new TTX analogs in pufferfish, newts and a frog. Those analogs were isolated and their chemical structures were determined. The analogs provided valuable information on biosynthetic as well as metabolic pathways of TTX and on structure-activity relationship.
- Link information
- ID information
-
- ISSN : 0731-3837
- Web of Science ID : WOS:A1996UQ07900002