2003年3月
Suppressive effect of overexpressed connective tissue growth factor on tumor cell growth in a human oral squamous cell carcinoma-derived cell line
CANCER LETTERS
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- 巻
- 192
- 号
- 2
- 開始ページ
- 205
- 終了ページ
- 214
- 記述言語
- 英語
- 掲載種別
- 研究論文(学術雑誌)
- DOI
- 10.1016/S0304-3835(02)00718-8
- 出版者・発行元
- ELSEVIER SCI IRELAND LTD
Connective tissue growth factor (CTGF) is known to be a multifunctional growth factor that is overexpressed. in several types of malignancies. In this study, effects of CTGF gene overexpression on the phenotypes of oral squamous cell carcinoma cells were investigated by using a cell line with undetectable endogenous CTGF expression. Surprisingly, our results indicated that CTGF-overexpressed clones were characterized by attenuated cell growth and less potent tumorigenicity, with coincidental downregulation of prothymosin a gene. Although CTGF is known to promote cell proliferation in mesenchymal cells, our present results suggest that CTGF acts as a negative regulator of the cell growth in oral squamous cell carcinoma possibly through its interaction with growth modifiers inside the cell. (C) 2003 Elsevier Science Ireland Ltd. All rights reserved.
- リンク情報
- ID情報
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- DOI : 10.1016/S0304-3835(02)00718-8
- ISSN : 0304-3835
- Web of Science ID : WOS:000182219700010