1999年8月
[Regulation of the microtubule-dependent process formation. A review based on a comparison between the neuron and the renal glomerular podocyte].
Kaibogaku zasshi. Journal of anatomy
- ,
- ,
- ,
- ,
- 巻
- 74
- 号
- 4
- 開始ページ
- 429
- 終了ページ
- 39
- 記述言語
- 日本語
- 掲載種別
- 研究論文(学術雑誌)
Microtubular cytoskeletons play a crucial role in the morphogenesis of process-bearing cells, such as the neuron and the renal glomerular podocyte. Microtubules are bundled and stabilized by various microtubule-associated proteins, providing a mechanical basis to maintain the deviated morphology of cell processes. To support the process morphology, microtubules are also associated with other cytoskeletal elements such as actin and intermediate filaments. The microtubular polarity is uniformly plus-end-distal in neuronal axons, whereas in dendrites as well as in podocytes, the polarity is revealed to be non-uniform (i.e., both plus-end-distal and minus-end-distal microtubules are present in cell processes). Recently, this non-uniformity is reported to be established by a microtubule-dependent motor protein. Motor proteins are capable to drive the intracellular transport of cytoskeletal elements in addition to that of membrane vesicles. It is still an open question whether cytoskeletal elements are transported along cell processes as subunits or as polymers.
- リンク情報
- ID情報
-
- ISSN : 0022-7722
- PubMed ID : 10496088
- SCOPUS ID : 33747255080