Mikihiro Fujiya

Profile Information

Affiliation: Professor, Division of Gastroenterology, Department of Internal Medicine, Asahikawa Medical University

Degree: Reduced Expression of Syndecan-1 Affects Metastatic Potential and Clinical Outcome in Patients with Colorectal Cancer(Asahikawa Medical College)

J-GLOBAL ID: 200901049600907040
researchmap Member ID: 1000307296

Research Interests

Gaseroenterology

Research Areas

Life sciences / Gastroenterology /

Major Research History

Jun, 2021 - Jan, 2024

教授, 内科学講座病態代謝・消化器・血液腫瘍制御内科学分野（消化器・内視鏡学部門）, 旭川医科大学
Feb, 2004 - May, 2006

シカゴ大学医学部消化器科(米国)

Education

Major Committee Memberships

Jun, 2021 - Present

支部長, 日本消化器がん検診学会北海道支部
Jun, 2021 - Present

理事, 日本消化器がん検診学会
Apr, 2021 - Present

大学評議員, 日本内科学会北海道支部
Sep, 2020 - Present

社団評議員, 日本消化器内視鏡学会
Mar, 2018 - Present

財団評議員, 日本消化器病学会

Awards

Major Papers

417

The Bacillus subtilis Quorum-Sensing Molecule CSF Contributes to Intestinal Homeostasis via OCTN2, a Host Cell Membrane Transporter

Mikihiro Fujiya, Mark W. Musch, Yasushi Nakagawa, Shien Hu, John Alverdy, Yutaka Kohgo, Olaf Schneewind, Bana Jabri, Eugene B. Chang

Cell Host & Microbe, 1(4) 299-308, Jun, 2007 Peer-reviewedLead author
Translational Inhibition of Colonic Epithelial Heat Shock Proteins by IFN-γ and TNF-α in Intestinal Inflammation

Shien Hu, Mae J. Ciancio, Maor Lahav, Mikihiro Fujiya, Lev Lichtenstein, Shrikant Anant, Mark W. Musch, Eugene B. Chang

Gastroenterology, 133(6) 1893-1904, Dec, 2007 Peer-reviewed
Cytokine Regulation of OCTN2 Expression and Activity in Small and Large Intestine

Mikihiro Fujiya, Yuhei Inaba, Mark W. Musch, Shien Hu, Yutaka Kohgo, Eugene B. Chang

INFLAMMATORY BOWEL DISEASES, 17(4) 907-916, Apr, 2011 Peer-reviewed
Probiotic-Derived Polyphosphate Enhances the Epithelial Barrier Function and Maintains Intestinal Homeostasis through Integrin-p38 MAPK Pathway

Shuichi Segawa, Mikihiro Fujiya, Hiroaki Konishi, Nobuhiro Ueno, Naoyuki Kobayashi, Tatsuro Shigyo, Yutaka Kohgo

PLOS ONE, 6(8) e23278, Aug, 2011 Peer-reviewedCorresponding author
Image-enhanced endoscopy for the diagnosis of colon neoplasms

Mikihiro Fujiya, Yutaka Kohgo

GASTROINTESTINAL ENDOSCOPY, 77(1) 111-U288, Jan, 2013 Peer-reviewedLead authorCorresponding author
microRNA-18a induces apoptosis in colon cancer cells via the autophagolysosomal degradation of oncogenic heterogeneous nuclear ribonucleoprotein A1

M. Fujiya, H. Konishi, M. K. Mohamed Kamel, N. Ueno, Y. Inaba, K. Moriichi, H. Tanabe, K. Ikuta, T. Ohtake, Y. Kohgo

ONCOGENE, 33(40) 4847-4856, Oct, 2014 Peer-reviewedLead authorCorresponding author
Decreased numbers of vascular networks and irregular vessels on narrow-band imaging are useful findings for distinguishing intestinal lymphoma from lymphoid hyperplasia

Mikihiro Fujiya, Shin Kashima, Katsuya Ikuta, Tatsuya Dokoshi, Aki Sakatani, Kazuyuki Tanaka, Katsuyoshi Ando, Nobuhiro Ueno, Motoya Tominaga, Yuhei Inaba …

GASTROINTESTINAL ENDOSCOPY, 80(6) 1064-1071, Dec, 2014 Peer-reviewedLead authorCorresponding author
Efficacy and adverse events of EMR and endoscopic submucosal dissection for the treatment of colon neoplasms: a meta-analysis of studies comparing EMR and endoscopic submucosal dissection

Mikihiro Fujiya, Kazuyuki Tanaka, Tatsuya Dokoshi, Motoya Tominaga, Nobuhiro Ueno, Yuhei Inaba, Takahiro Ito, Kentaro Moriichi, Yutaka Kohgo

GASTROINTESTINAL ENDOSCOPY, 81(3) 583-595, Mar, 2015 Peer-reviewedLead authorCorresponding author
Polyphosphate, an active molecule derived from probiotic Lactobacillus brevis, improves the fibrosis in murine colitis

Shin Kashima, Mikihiro Fujiya, Hiroaki Konishi, Nobuhiro Ueno, Yuhei Inaba, Kentaro Moriichi, Hiroki Tanabe, Katsuya Ikuta, Takaaki Ohtake, Yutaka Kohgo

TRANSLATIONAL RESEARCH, 166(2) 163-175, Aug, 2015 Peer-reviewedCorresponding author
Probiotic-derived ferrichrome inhibits colon cancer progression via JNK-mediated apoptosis

Hiroaki Konishi, Mikihiro Fujiya, Hiroki Tanaka, Nobuhiro Ueno, Kentaro Moriichi, Junpei Sasajima, Katsuya Ikuta, Hiroaki Akutsu, Hiroki Tanabe, Yutaka Kohgo

NATURE COMMUNICATIONS, 7 12365, Aug, 2016 Peer-reviewedLead authorCorresponding author
Long-Chain Polyphosphate Is a Potential Agent for Inducing Mucosal Healing of the Colon in Ulcerative Colitis

Mikihiro Fujiya, Nobuhiro Ueno, Shin Kashima, Kazuyuki Tanaka, Aki Sakatani, Katsuyoshi Ando, Kentaro Moriichi, Hiroaki Konishi, Naoya Kamiyama, Yoshikazu Tasaki …

CLINICAL PHARMACOLOGY & THERAPEUTICS, 107(2) 452-461, Feb, 2020 Peer-reviewedLead author
A tumor-specific modulation of heterogeneous ribonucleoprotein A0 promotes excessive mitosis and growth in colorectal cancer cells

Hiroaki Konishi, Mikihiro Fujiya, Shin Kashima, Aki Sakatani, Tatsuya Dokoshi, Katsuyoshi Ando, Nobuhiro Ueno, Takuya Iwama, Kentaro Moriichi, Hiroki Tanaka …

CELL DEATH & DISEASE, 11(4), Apr, 2020
Bacteria-derived ferrichrome inhibits tumor progression in sporadic colorectal neoplasms and colitis-associated cancer

Takuya Iwama, Mikihiro Fujiya, Hiroaki Konishi, Hiroki Tanaka, Yuki Murakami, Takehito Kunogi, Takahiro Sasaki, Keitaro Takahashi, Katsuyoshi Ando, Nobuhiro Ueno …

CANCER CELL INTERNATIONAL, 21(1), Jan, 2021 Peer-reviewedCorresponding author
Probiotic Aspergillus oryzae produces anti-tumor mediator and exerts anti-tumor effects in pancreatic cancer through the p38 MAPK signaling pathway

Hiroaki Konishi, Shotaro Isozaki, Shin Kashima, Kentaro Moriichi, Satoshi Ichikawa, Kazuki Yamamoto, Chikage Yamamura, Katsuyoshi Ando, Nobuhiro Ueno, Hiroaki Akutsu …

SCIENTIFIC REPORTS, 11(1) 11070-11070, May, 2021 Peer-reviewedLast author

Major Misc.

246

消化器病専門医研修カリキュラム改訂下部消化管

穂苅量太, 菅智明, 鶴田修, 藤谷幹浩, 小林宏寿

日本消化器病学会雑誌, 110(5) 808-811, May, 2013

Major Books and Other Publications

Endoscopic mucosal resection and Endoscopic piecemeal mucosal resection for colorectal neoplasia. In: Niwa H, Tajiri H, Yasuda K, eds. New Challenges in Gastrointestinal Endoscopy. Tokyo: Springer, 2008; 346-352.

Springer, 2008
標準消化器病学疾患各論小腸・結腸疾患牛乳不耐症

林紀夫，日比紀文，坪内博仁編，医学書院, 2003
標準消化器病学疾患各論小腸・結腸疾患蛋白漏出性胃腸症

林紀夫，日比紀文，坪内博仁編，医学書院, 2003
標準消化器病学疾患各論小腸・結腸疾患吸収不良症候群

林紀夫，日比紀文，坪内博仁編，医学書院, 2003

Major Professional Memberships

Major Research Projects

プロバイオティクス由来フェリクロームを用いた新規抗腫瘍薬開発

橋渡し研究加速ネットワークプログラムシーズ preB, AMED, Apr, 2020 - Mar, 2021

藤谷幹浩
プロバイオティクス由来の活性物質ポリリン酸を用いた新規炎症性腸疾患治療薬の開発

橋渡し研究加速ネットワークプログラムシーズC, AMED, Apr, 2016 - Mar, 2017

藤谷幹浩
プロバイオティクス由来の活性物質ポリリン酸を用いた新規炎症性腸疾患治療薬の開発

橋渡し研究加速ネットワークプログラムシーズB, 文部科学省, Apr, 2013 - Mar, 2016

藤谷幹浩

Major Industrial Property Rights

特許第5660508号、EP2559437、US10792315 Intestinal Protectant

FUJIYA Mikihiro, KOHGO Yutaka, UENO Nobuhiro
特許第6830255号、EP3400952、US10576126 抗腫瘍剤

藤谷幹浩, 小西弘晃, 盛一健太郎

Profile Information

Research Interests

Research Areas

Major Research History

Education

Major Committee Memberships

Awards

Major Papers

Major Misc.

Major Books and Other Publications

Major Professional Memberships

Major Research Projects

Major Industrial Property Rights

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