NAKAHIGASHI KENJI - My portal

Profile Information

Affiliation: Project Associate Professor, Graduate School of Media and Governance, Major in Media and Governance, Keio University

Degree: Ph. D(Kyoto Univ.)

Researcher number: 70322740
J-GLOBAL ID: 200901012912204908
researchmap Member ID: 1000312272

Research Areas

Life sciences / Genomics /

Research History

Apr, 2005

政策・メディア研究科助教授（有期・特別研究教員）
Apr, 2002 - Sep, 2004

Reserch Institute for Biological Sciences OKAYAMA
Nov, 1999 - Mar, 2002

京都大学大学院理学研究科生物物理学教室情報分子細胞学講座ゲノム情報分野
Apr, 1993 - Oct, 1999

株式会社エイチエスピー研究所
Apr, 1991 - Mar, 1993

明治乳業株式会社ヘルスサイエンス研究所

Education

- 1991

Molecular biology, Biophysics, Kyoto University

Committee Memberships

Apr, 2009

委員, 鶴岡市環境審議会
Apr, 2009

Committee Member, 鶴岡市環境審議会

Awards

2005

日本植物生理学会論文賞, Arabidopsis TERMINAL FLOWER 2 gene encodes a heterochromatin protein 1 homolog and represses both FLOWERING LOCUS to regulate flowering time and several floral homeotic genes. Plant Cell Physiol. 44(6): 555-564

Kotake, T, Takada, S, Nakahigashi, K, Ohto, M, Goto, K

Papers

ラン藻Synechocystis sp.PCC6803株の遊離脂肪酸産生株における脂肪酸輸送体遺伝子発現効果

NAKAHIGASHI KENJI

日本植物生理学会年会要旨集, 56th 128, Mar 9, 2015
GenoBase: comprehensive resource database of Escherichia coli K-12

Yuta Otsuka, Ai Muto, Rikiya Takeuchi, Chihiro Okada, Motokazu Ishikawa, Koichiro Nakamura, Natsuko Yamamoto, Hitomi Dose, Kenji Nakahigashi, Shigeki Tanishima …

NUCLEIC ACIDS RESEARCH, 43(D1) D606-D617, Jan, 2015
Effect of codon adaptation on codon-level and gene-level translation efficiency in vivo

Kenji Nakahigashi, Yuki Takai, Yuh Shiwa, Mei Wada, Masayuki Honma, Hirofumi Yoshikawa, Masaru Tomita, Akio Kanai, Hirotada Mori

BMC GENOMICS, 15, Dec, 2014
山形県庄内産野菜・漬物由来の乳酸菌を活用した漬物開発

NAKAHIGASHI KENJI

日本乳酸菌学会誌, 25(2) 124, Jul 5, 2014
The tRNA thiolation pathway modulates the intracellular redox state in Escherichia coli

Toru Nakayashiki, Natsumi Saito, Rikiya Takeuchi, Hiroshi Kadokura, Kenji Nakahigashi, Barry L. Wanner, Hirotada Mori

Journal of Bacteriology, 195(9) 2039-2049, May, 2013
Metabolomic study of Chilean biomining bacteria Acidithiobacillus ferrooxidans strain Wenelen and Acidithiobacillus thiooxidans strain Licanantay

Patricio Martinez, Sebastian Galvez, Norimasa Ohtsuka, Marko Budinich, Maria Paz Cortes, Cristian Serpell, Kenji Nakahigashi, Akiyoshi Hirayama, Masaru Tomita, Tomoyoshi Soga …

METABOLOMICS, 9(1) 247-257, Feb, 2013
CE-MSを用いた芳香族化合物の微生物分解代謝物の測定と土壌汚染モニタリングへの応用

NAKAHIGASHI KENJI

山形県環境科学研究センター年報(Web), (18) WEB ONLY 58 JST COPY SERVICE N, Jan, 2012
Metabolic regulation analysis of wild-type and arcA mutant Escherichia coli under nitrate conditions using different levels of omics data

Yoshihiro Toya, Kenji Nakahigashi, Masaru Tomita, Kazuyuki Shimizu

MOLECULAR BIOSYSTEMS, 8(10) 2593-2604, 2012
Catabolic regulation analysis of Escherichia coli and its crp, mlc, mgsA, pgi and ptsG mutants

Ruilian Yao, Yuki Hirose, Dayanidhi Sarkar, Kenji Nakahigashi, Qin Ye, Kazuyuki Shimizu

MICROBIAL CELL FACTORIES, 10(67), Aug, 2011 Peer-reviewed
Deep sequencing reveals as-yet-undiscovered small RNAs in Escherichia coli

Atsuko Shinhara, Motomu Matsui, Kiriko Hiraoka, Wataru Nomura, Reiko Hirano, Kenji Nakahigashi, Masaru Tomita, Hirotada Mori, Akio Kanai

BMC GENOMICS, 12(428), Aug, 2011 Peer-reviewed
An artificial glycolysis operon library toward elucidation of possible "operon rule"

Tsuge, Kenji, Nakahigashi, Kenji, Togashi, Takashi, Hasebe, Masako, Takai, Yuki, Hasegawa, Miki, Tomita, Masaru, Itaya, Mitsuhiro

GENES & GENETIC SYSTEMS, 85(6) 454-454, Dec, 2010
C-13-Metabolic Flux Analysis for Batch Culture of Escherichia coli and Its pyk and pgi Gene Knockout Mutants Based on Mass Isotopomer Distribution of Intracellular Metabolites

Yoshihiro Toya, Nobuyoshi Ishii, Kenji Nakahigashi, Takashi Hirasawa, Tomoyoshi Soga, Masaru Tomita, Kazuyuki Shimizu

BIOTECHNOLOGY PROGRESS, 26(4) 975-992, Jul, 2010
A systematic survey of in vivo obligate chaperonin-dependent substrates

Kei Fujiwara, Yasushi Ishihama, Kenji Nakahigashi, Tomoyoshi Soga, Hideki Taguchi

EMBO JOURNAL, 29(9) 1552-1564, May, 2010 Peer-reviewed
マルチオミクス(multi-omics)解析で見えてきた大腸菌の遺伝･環境変化に対する応答機構

中東憲治, 冨田勝

遺伝子医学 MOOK, 16 152-158, Feb 10, 2010
Update on the Keio collection of Escherichia coli single-gene deletion mutants

Natsuko Yamamoto, Kenji Nakahigashi, Tomoko Nakamichi, Mihoko Yoshino, Yuki Takai, Yae Touda, Akemi Furubayashi, Satoko Kinjyo, Hitomi Dose, Miki Hasegawa …

MOLECULAR SYSTEMS BIOLOGY, 5 335, Dec, 2009 Peer-reviewed
Systematic phenome analysis of Escherichia coli multiple-knockout mutants reveals hidden reactions in central carbon metabolism

Kenji Nakahigashi, Yoshihiro Toya, Nobuyoshi Ishii, Tomoyoshi Soga, Miki Hasegawa, Hisami Watanabe, Yuki Takai, Masayuki Honma, Hirotada Mori, Masaru Tomita

MOLECULAR SYSTEMS BIOLOGY, 5(306), Sep, 2009 Peer-reviewed
Multiple high-throughput analyses monitor the response of E-coli to perturbations

Nobuyoshi Ishii, Kenji Nakahigashi, Tomoya Baba, Martin Robert, Tomoyoshi Soga, Akio Kanai, Takashi Hirasawa, Miki Naba, Kenta Hirai, Aminul Hoque …

SCIENCE, 316(5824) 593-597, Apr, 2007 Peer-reviewed
Epigenetic maintenance of the vernalized state in Arabidopsis thaliana requires LIKE HETEROCHROMATIN PROTEIN 1

SB Sung, YH He, TW Eshoo, Y Tamada, L Johnson, K Nakahigashi, K Goto, SE Jacobsen, RM Amasino

NATURE GENETICS, 38(6) 706-710, Jun, 2006 Peer-reviewed
Large-scale identification of protein-protein interaction of Escherichia coli K-12

M Arifuzzaman, M Maeda, A Itoh, K Nishikata, C Takita, R Saito, T Ara, K Nakahigashi, HC Huang, A Hirai …

GENOME RESEARCH, 16(5) 686-691, May, 2006 Peer-reviewed
The Arabidopsis HETEROCHROMATIN PROTEIN1 homolog (TERMINAL FLOWER2) silences genes within the euchromatic region but not genes positioned in heterochromatin

K Nakahigashi, Z Jasencakova, Schubert, I, K Goto

PLANT AND CELL PHYSIOLOGY, 46(11) 1747-1756, Nov, 2005 Peer-reviewed

Books and Other Publications

Systems Biology and Biotechnology of Escherichia coli

Hirotada Mori, Natsuko Yamamoto, Hitomi Dose, Kenji Nakahigashi, Kirill A. Datsenko, Barry L. Wanner

Springer Netherlands, 2009 (ISBN: 9781402093937)
ベーシックマスター生化学

NAKAHIGASHI KENJI (Role: Joint author, 166-187)

オーム社･東京, Nov, 2008 (ISBN: 9784274206047)

Presentations

中鎖脂肪酸を切り出すチオエステラーゼ遺伝子とアシルキャリアープロテイン遺伝子の同時導入によるChlamydomonas reinhardtiiの脂肪酸の炭素鎖長の改変

NAKAHIGASHI KENJI

日本農芸化学会大会, Mar 5, 2015
大腸菌の増殖を抑制する人工低分子RNAとその制御メカニズム

NAKAHIGASHI KENJI

日本RNA学会年会, Jul 23, 2014
Hfqとデグラドソーム変異によるsRNAとmRNA翻訳への影響

NAKAHIGASHI KENJI

日本分子生物学会年会, 2014
人工低分子RNAによる大腸菌の増殖抑制とその制御メカニズムの解析

NAKAHIGASHI KENJI

日本分子生物学会年会, 2014
大腸菌の栄養飢餓環境におけるRNA‐seq解析

NAKAHIGASHI KENJI

日本分子生物学会年会, 2014
大腸菌の栄養飢餓環境とRNA分解

NAKAHIGASHI KENJI

日本ゲノム微生物学会年会, 2014
遺伝子レベル,コドンレベルでの翻訳効率解析

NAKAHIGASHI KENJI

日本ゲノム微生物学会年会, 2014
ゲノム中の人工オペロンの配置問題に関する検討

NAKAHIGASHI KENJI

第35回日本分子生物学会年会, Dec, 2012, 日本分子生物学会
Trypanosoma cruzi解糖系の再構築

NAKAHIGASHI KENJI

第35回日本分子生物学会年会, Dec, 2012, 日本分子生物学会
大腸菌の栄養饑餓環境における遺伝子発現応答

NAKAHIGASHI KENJI

第35回日本分子生物学会年会, Dec, 2012, 日本分子生物学会
Ribosome profilingと抗生物質の特性を利用した大腸菌翻訳開始部位の再アノテーション

NAKAHIGASHI KENJI

第35回日本分子生物学会年会, Dec, 2012, 日本分子生物学会
微生物叢解析及びメタボローム解析から見た沢庵漬けの発酵過程

NAKAHIGASHI KENJI

第35回日本分子生物学会年会, Dec, 2012, 日本分子生物学会
日本新産Chlamydomonas reinhardtii(緑藻網)プラス型･マイナス型交配株のゲノム解析

NAKAHIGASHI KENJI

第35回日本分子生物学会年会, Dec, 2012, 日本分子生物学会
マウス腸管内容物のメタボローム解析

NAKAHIGASHI KENJI

日本農芸化学会大会, Mar, 2012, (発行年月日)Vol.2012 Page.WEB ONLY 3C25P03 (2012.03.05)
ゲノムデザイン学:人工解糖系オペロンの転写・翻訳解析

NAKAHIGASHI KENJI

日本農芸化学会大会, Mar, 2012
階層的な代謝応答から理解する大腸菌緊縮応答の代謝メカニズム

NAKAHIGASHI KENJI

日本農芸化学会大会, Mar, 2012
Analysis of the response of Escherichia coli cells to the nutritional stress by using various gene disruptants

牧泰史, 道瀬ひとみ, 竹内力矢, 上田雅美, 和田明, 古池晶, 吉田秀司, 中東憲治, 森浩禎

第34回日本分子生物学会年会, Dec 15, 2011, 日本分子生物学会
Local structures affecting ribosome density on mRNA

中東憲治, 高井幸, 牧泰史, 森浩禎, 冨田勝

第34回日本分子生物学会年会, Dec 15, 2011, 日本分子生物学会
Genome designing biology: Construction of glycolytic pathway by artificial operon

柘植謙爾, 中東憲治, 富樫貴, 長谷部雅子, 高井幸, 長谷川美紀, 五十嵐康行, 杉山直幸, 石濱泰, 冨田勝, 板谷光泰

第34回日本分子生物学会年会, Dec 13, 2011, 日本分子生物学会
High resolution analysis of protein synthesis by ribosome mapping on mRNA

NAKAHIGASHI KENJI

The 2011 UK-Japan Workshop on Microbial Systems Biology, Oct 25, 2011, JST and BBSRC Invited