2008年12月
Reduction of oligodendrocyte myelin glycoprotein expression following facial nerve transection
JOURNAL OF CHEMICAL NEUROANATOMY
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- 巻
- 36
- 号
- 3-4
- 開始ページ
- 209
- 終了ページ
- 215
- 記述言語
- 英語
- 掲載種別
- DOI
- 10.1016/j.jchemneu.2008.08.006
- 出版者・発行元
- ELSEVIER SCIENCE BV
Oligodendrocyte myelin glycoprotein (OMgp) has been thought to be expressed in the oligodendrocytes and inhibit the regeneration of the nerves by binding to the Nogo receptor expressed in neurons in the central nervous system (CNS). However, OMgp is expressed in the CNS in the neurons as well as oligodendrocytes. In order to help understanding the physiological role of neuronal OMgp, we examined the change of OMgp expression in the facial nucleus after the facial nerve transection. Real-time RT-pCR and Western blot analysis showed a clown-regulation of OMgp expression in the facial nucleus 5-7 (mRNA) or 5-14 (protein) days after transection. Thereafter, expression of OMgp returned to the control level at 28 clays after axotomy. Subsequent analysis using in silo hybridization histochemistry and immunohistochemistry established that the decrease of OMgp expression was attributable to the expression in facial motoneurons, but not in oligodendrocytes. These findings suggest a possibility that the change of neuronal OMgp expression might be involved in reconnection of neural circuit between axotomized facial neuron and upper motor neuron after transection. (C) 2008 Elsevier B.V. All rights reserved.
- リンク情報
- ID情報
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- DOI : 10.1016/j.jchemneu.2008.08.006
- ISSN : 0891-0618
- Web of Science ID : WOS:000261747600010