Minoru Wakamori

Profile Information

Affiliation: Tohoku University

Degree: (BLANK)(Tohoku University)

J-GLOBAL ID: 200901024315668870
researchmap Member ID: 1000361685

Research Interests

Research Areas

Research History

Apr, 2020 - Present

Professor, Graduate School of Dentistry, Tohoku University
Apr, 2007 - Mar, 2020

Graduate School of Dentistry, Tohoku University
Apr, 2004 - Mar, 2007

Graduate School of Engineering, Department of Synthetic Chemistry and Biological Chemistry, Kyoto University
Apr, 2002 - Mar, 2005

客員准教授, 生理学研究所生体情報研究系情報記憶研究部門（客員部門）, 岡崎国立共同研究機構
Apr, 2003 - Mar, 2004

Graduate School of Medical and Dental Sciences, Kagoshima University
Mar, 2001 - Mar, 2003

Faculty of Medicine, Department of Medicine, Kagoshima University
Dec, 1995 - Feb, 2001

助手, 生理学研究所生体情報研究系液性情報研究部門, 岡崎国立共同研究機構
Apr, 1995 - Nov, 1995

助手, 医学部分子薬理学及び生物物理学研究所, オハイオ州立シンシナティ大学
Jul, 1994 - Mar, 1995

博士研究員, 医学部分子薬理学及び生物物理学研究所, オハイオ州立シンシナティ大学
Apr, 1992 - Jun, 1994

博士研究員, 医学部薬理学及び細胞生物物理学講座, オハイオ州立シンシナティ大学

Papers

Periodontal Ligaments Enhance Neurite Outgrowth in Trigeminal Ganglion Neurons through Wnt5a Production Induced by Mechanical Stimulation

Kaori Takahashi, Takashi Yoshida, Minoru Wakamori

American Journal of Physiology-Cell Physiology, 323(6) C1704-C1719, Nov 14, 2022 Peer-reviewedLast authorCorresponding author
A parasympathetic neurotransmitter induces myoepithelial cell differentiation during salivary gland development

Yuki Shindo, Hannah M. Nakamura, Junichi Nakai, Minoru Wakamori, Takashi Nakamura

Experimental Cell Research, 416(1) 113137-113137, Jul, 2022 Peer-reviewed
Identification of ultra-rare disruptive variants in voltage-gated calcium channel-encoding genes in Japanese samples of schizophrenia and autism spectrum disorder

Chenyao Wang, Shin-ichiro Horigane, Minoru Wakamori, Shuhei Ueda, Takeshi Kawabata, Hajime Fujii, Itaru Kushima, Hiroki Kimura, Kanako Ishizuka, Yukako Nakamura …

Translational Psychiatry, 12(1) 84-84, Feb, 2022 Peer-reviewedLead author
Mode-selective inhibitory effects of eugenol on the mouse TRPV1 channel.

Kaori Takahashi, Takashi Yoshida, Minoru Wakamori

Biochemical and biophysical research communications, 556 156-162, Jun 4, 2021 Peer-reviewedLast author
Capsaicin and Proton Differently Modulate Activation Kinetics of Mouse Transient Receptor Potential Vanilloid-1 Channel Induced by Depolarization.

Kaori Takahashi, Kentaro Araki, Hideo Miyamoto, Rikimaru Shirakawa, Takashi Yoshida, Minoru Wakamori

Frontiers in pharmacology, 12 672157-672157, 2021 Peer-reviewedLast authorCorresponding author
Paeonol, an Ingredient of Kamishoyosan, Reduces Intracellular Lipid Accumulation by Inhibiting Glucocorticoid Receptor Activity in 3T3-L1 Cells

Masayuki Izumi, Takashi Yoshida, Takashi Nakamura, Minoru Wakamori

Nutrients, 12(2) 309-309, Jan 24, 2020 Peer-reviewedLast authorCorresponding author
Synthesis of quinolyl-pyrrole derivatives as novel environment-sensitive fluorescent probes

Shinotsuka R, Oba T, Mitome T, Masuya T, Ito S, Murakami Y, Kagenishi T, Kodama Y, Matsuda M, Yoshida T …

Journal of Photochemistry and Photobiology A: Chemistry, 382 111900-111900, 2019 Peer-reviewed
Protective effects of duloxetine against cerebral ischemia-reperfusion injury via transient receptor potential melastatin 2 inhibition

Toda T, Yamamoto S, Umehara N, Mori Y, Wakamori M, Shimizu S

Journal of Pharmacology and Experimental Therapeutics, 368(2) 246-254, 2019 Peer-reviewed
Differential binding of tetrodotoxin and its derivatives to voltage-sensitive sodium channel subtypes (Na(v)1.1 to Na(v)1.7)

Tadaaki Tsukamoto, Yukie Chiba, Minoru Wakamori, Tomoshi Yamada, Shunsuke Tsunogae, Yuko Cho, Ryo Sakakibara, Takuya Imazu, Shouta Tokoro, Yoshiki Satake …

BRITISH JOURNAL OF PHARMACOLOGY, 174(21) 3881-3892, Nov, 2017 Peer-reviewed
Alternative splicing in the C-terminal tail of Ca(v)2.1 is essential for preventing a neurological disease in mice

Tomonori Aikawa, Takaki Watanabe, Taisuke Miyazaki, Takayasu Mikuni, Minoru Wakamori, Miyano Sakurai, Hidenori Aizawa, Nobutaka Ishizu, Masahiko Watanabe, Masanobu Kano …

HUMAN MOLECULAR GENETICS, 26(16) 3094-3104, Aug, 2017 Peer-reviewed
Pharmacological properties of SAK3, a novel T-type voltage-gated Ca2+ channel enhancer

Yasushi Yabuki, Kazuya Matsuo, Hisanao Izumi, Hidaka Haga, Takashi Yoshida, Minoru Wakamori, Akikazu Kakei, Kenji Sakimura, Takaichi Fukuda, Kohji Fukunaga

NEUROPHARMACOLOGY, 117 1-13, May, 2017 Peer-reviewed
Inhibition of veratridine-induced delayed inactivation of the voltage-sensitive sodium channel by synthetic analogs of crambescin B

Tadaaki Tsukamoto, Yukie Chiba, Atsuo Nakazaki, Yuki Ishikawa, Yoshiki Nakane, Yuko Cho, Mad Yotsu-Yamashita, Toshio Nishikawa, Minoru Wakamori, Keiichi Konoki

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 27(5) 1247-1251, Mar, 2017 Peer-reviewed
Unraveling the rat blood genome-wide transcriptome after oral administration of lavender oil by a two-color dye-swap DNA microarray approach

Motohide Hori, Hiroko Kubo, Junko Shibato, Tomomi Saito, Tetsuo Ogawa, Minoru Wakamori, Yoshinori Masuo, Seiji Shioda, Randeep Rakwal

Genomics Data, 8 139-145, Jun 1, 2016 Peer-reviewed
Compromised maturation of GABAergic inhibition underlies abnormal network activity in the hippocampus of epileptic Ca2+ channel mutant mice, tottering

Akito Nakao, Takafumi Miki, Ken Shimono, Hiroaki Oka, Tomohiro Numata, Shigeki Kiyonaka, Kaori Matsushita, Hiroo Ogura, Tetsuhiro Niidome, Jeffrey L. Noebels …

PFLUGERS ARCHIV-EUROPEAN JOURNAL OF PHYSIOLOGY, 467(4) 737-752, Apr, 2015 Peer-reviewed
Inhibitory effects of AG490 on H2O2-induced TRPM2-mediated Ca2+ entry

Shunichi Shimizu, Ryo Yonezawa, Tamio Hagiwara, Takashi Yoshida, Nobuaki Takahashi, Satoshi Hamano, Takaharu Negoro, Takahiro Toda, Minoru Wakamori, Yasuo Mori …

EUROPEAN JOURNAL OF PHARMACOLOGY, 742 22-30, Nov, 2014 Peer-reviewed
Development of Purkinje cell degeneration in a knockin mouse model reveals lysosomal involvement in the pathogenesis of SCA6

Toshinori Unno, Minoru Wakamori, Masato Koike, Yasuo Uchiyama, Kinya Ishikawa, Hisahiko Kubota, Takashi Yoshida, Hiroko Sasakawa, Christoph Peters, Hidehiro Mizusawa …

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 109(43) 17693-17698, Oct, 2012 Peer-reviewed
Rab3-interacting Molecule gamma Isoforms Lacking the Rab3-binding Domain Induce Long Lasting Currents but Block Neurotransmitter Vesicle Anchoring in Voltage-dependent P/Q-type Ca2+ Channels

Yoshitsugu Uriu, Shigeki Kiyonaka, Takafumi Miki, Masakuni Yagi, Satoshi Akiyama, Emiko Mori, Akito Nakao, Aaron M. Beedle, Kevin P. Campbell, Minoru Wakamori …

JOURNAL OF BIOLOGICAL CHEMISTRY, 285(28) 21750-21767, Jul, 2010 Peer-reviewed
A Missense Mutation of the Gene Encoding Voltage-Dependent Sodium Channel (Na(v)1.1) Confers Susceptibility to Febrile Seizures in Rats

Tomoji Mashimo, Iori Ohmori, Mamoru Ouchida, Yukihiro Ohno, Toshiko Tsurumi, Takafumi Miki, Minoru Wakamori, Shizuka Ishihara, Takashi Yoshida, Akiko Takizawa …

JOURNAL OF NEUROSCIENCE, 30(16) 5744-5753, Apr, 2010 Peer-reviewed
A Pathogenic C Terminus-truncated Polycystin-2 Mutant Enhances Receptor-activated Ca2+ Entry via Association with TRPC3 and TRPC7

Kyoko Miyagi, Shigeki Kiyonaka, Kazunori Yamada, Takafumi Miki, Emiko Mori, Kenta Kato, Tomohiro Numata, Yuichi Sawaguchi, Takuro Numaga, Toru Kimura …

JOURNAL OF BIOLOGICAL CHEMISTRY, 284(49) 34400-34412, Dec, 2009 Peer-reviewed
Knockdown of Ca(v)2.1 calcium channels is sufficient to induce neurological disorders observed in natural occurring Cacna1a mutants in mice

Hiromitsu Saito, Motohiro Okada, Takafumi Miki, Minoru Wakamori, Akira Futatsugi, Yasuo Mori, Katsuhiko Mikoshiba, Noboru Suzuki

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 390(3) 1029-1033, Dec, 2009 Peer-reviewed

Misc.

121

Inhibition of Voltage-gated Sodium Channel Subtypes (Na_v1.1-Na_v1.7) by Tetrodotoxin Analogues

塚本匡顕, 千葉雪絵, 若森実, 日高將文, 山田智士, 角替俊輔, 長由扶子, 榊原良, 今津拓也, 所聖太 …

天然有機化合物討論会講演要旨集(Web), 60th, 2018
The inhibitory mechanism of eugenol on TRPV1 channel

Takashi Yoshida, Kaori Takahashi, Minoru Wakamori

JOURNAL OF PHARMACOLOGICAL SCIENCES, 124 175P-175P, 2014
Cav2.1カルボキシル末端細胞質内ドメインの病態生理学的意義の検討

相川知徳, 宮崎太輔, 三國貴康, 重本隆一, 若森実, 狩野方伸, 渡邊雅彦, 水澤英洋, 渡瀬啓

臨床神経学, 53(12) 1495-1495, Dec, 2013
The inhibitory mechanism of eugenol on TRPV1 channel

Takashi Yoshida, Kaori Takahashi, Takashi Kikuchi, Minoru Wakamori

JOURNAL OF PHARMACOLOGICAL SCIENCES, 121 171P-171P, 2013
電位依存性チャネル

若森実, 三木崇史, 中尾章人, 高田宜則, 森泰生

脳神経科学イラストレイテッド改訂第3版, 2013 Invited
The conflicting effects of eugenol on TRPV1 channel

Takashi Yoshida, Takashi Kikuchi, Kaori Takahashi, Minoru Wakamori

JOURNAL OF PHARMACOLOGICAL SCIENCES, 118 249P-249P, 2012
TRP channels play a role in the mouse osteoblast cell line MC3T3-E1 under shear stress

Takashi Yoshida, Minoru Wakamori

JOURNAL OF PHARMACOLOGICAL SCIENCES, 115 220P-220P, 2011
Inactivation of voltage-gated CA^2+ channels and cone-rod dystrophy cord7. [Emerging Frontiers in Brain Research: Crossroads of metabolic regulaltion, stress response and disease. The 11th Meeting of Hirosaki International Forum of Medical Science. Communication Center of Hirosaki University School of Medicine. March 27-28,2009. Hirosaki, Japan.]

Wakamori Minoru, Uriu Yoshitsugu, Miki Takafumi, Kiyonaka Shigeki, Mori Yasuo

The Hirosaki medical journal, 61 S53-S62, 2010
Neuronal Ca2+-sensitive non-selective cation channels and TRPC5

Minoru Wakamori

Journal of Oral Biosciences, 52(4) 352-357, 2010
Modulation of TRPM5 channel activities by fatty acids

Minoru Wakamori, Takashi Yoshida, Takashi Kikuchi

JOURNAL OF PHARMACOLOGICAL SCIENCES, 112 38P-38P, 2010
ナトリウムチャネル遺伝子Scn1a変異ラットの開発解析研究

芹川忠夫, 大守伊織, 大内田守, 大野行弘, 鶴見東志子, 三木崇史, 若森実, 石原靜, 吉田卓史, 滝沢明子 …

てんかん治療研究振興財団研究年報, 21 29-36, 2010
Expression patterns of mechanosensitive TRP genes in MC3T3-E1 cells

Takashi Yoshida, Yuki Miyajima, Minoru Wakamori

JOURNAL OF PHARMACOLOGICAL SCIENCES, 109 176P-176P, 2009
FACILITATION OF TRPC5 CHANNEL BY CALCIUM

Minoru Wakamori, Takashi Yoshida, Shinichiro Yamamoto, Yasuo Mori

JOURNAL OF PHYSIOLOGICAL SCIENCES, 59 396-396, 2009
TRP CHANNELS PLAY A ROLE IN MECHANICAL RESPONSES IN STRETCHED OSTEOBLASTS

Takashi Yoshida, Yuki Miyajima, Minoru Wakamori

JOURNAL OF PHYSIOLOGICAL SCIENCES, 59 399-399, 2009
Hyperthermia-induced seizure-susceptible rats: a novel model of febrile seizures

Tomoji Mashimo, Iori Ohmori, Mamoru Ouchida, Yukihiro Ohno, Toshiko Tsurumi, Takafumi Miki, Minoru Wakamori, Yasuo Mori, Tadao Serikawa

NEUROSCIENCE RESEARCH, 65 S47-S47, 2009
A pyrazole compound selectively inhibits receptor activated TRPC3 channel

Kenta Kato, Shigeki Kiyonaka, Motohiro Nishida, Masakazu Ishii, Emiko Mori, Takuro Numaga, Takashi Yoshida, Takafumi Miki, Tsutomu Kobayashi, Takashi Morii …

JOURNAL OF PHARMACOLOGICAL SCIENCES, 106 210P-210P, 2008
Functional impact of RIM family on gating of voltage-dependent Ca2+ channels

Yoshitsugu Uriu, Minoru Wakamori, Shigeki Kiyonaka, Satoshi Akiyama, Takafumi Miki, Emiko Mori, Yasuo Mori

JOURNAL OF PHARMACOLOGICAL SCIENCES, 106 243P-243P, 2008
Functional analysis of spinocerebellar ataxia type 6 knock-in mice

T. Tanabe, H. Saegusa, M. Wakamori, Y. Matsuda, J. Wang, Y. Mori, S. Zong

JOURNAL OF NEUROCHEMISTRY, 102 227-227, Aug, 2007
Functional impact of an active zone scaffolding protein on gating of voltage-dependent calcium channels

Yoshitsugu Uriu, Minoru Wakamori, Takafumi Miki, Shigeki Kiyonaka, Yasuo Mori

JOURNAL OF PHARMACOLOGICAL SCIENCES, 103 128P-128P, 2007
Active zone scaffolding protein RIM1 confers sustained activity and neurotransmitter vesicle anchoring to presynaptic Ca2+ channels

Minoru Wakamori, Shigeki Kiyonaka, Takafumi Miki, Yoshitsugu Uriu, Yasuo Mori

YAKUGAKU ZASSHI-JOURNAL OF THE PHARMACEUTICAL SOCIETY OF JAPAN, 127 103-104, 2007

Professional Memberships

Research Projects

唾液腺発生における神経-器官相互作用の分子機構の解明と機能再生技術への応用

科学研究費助成事業, 国際共同研究加速基金(国際共同研究強化(B)), 日本学術振興会, Oct, 2021 - Mar, 2025

中村卓史, 若森実, 中村はな, 真藤裕基, 千葉雄太
エピプロフィンによる上皮間葉転換制御機構を応用したがん治療と器官原器複製術の開発

科学研究費助成事業, 基盤研究(C), 日本学術振興会, Apr, 2021 - Mar, 2024

中村卓史, 中村はな, 若森実
臨床ゲノム研究に基づく非興奮性細胞における電位依存性カルシウムチャネル機能の解明

科学研究費助成事業, 基盤研究(C), 日本学術振興会, Apr, 2020 - Mar, 2023

若森実, 中村卓史
The development of light-activatable proteins for inducing mechanical stimulation in the cells

Grants-in-Aid for Scientific Research, Grant-in-Aid for Challenging Exploratory Research, Japan Society for the Promotion of Science, Apr, 2015 - Mar, 2018

Yoshida Takashi, Wakamori Minoru
Pathophysiological analysis of oral diseases caused by dysregulation of cation channels

Grants-in-Aid for Scientific Research, Grant-in-Aid for Scientific Research (C), Japan Society for the Promotion of Science, Apr, 2015 - Mar, 2018

Wakamori Minoru
Exploring the regulatory mechanism of hypothalamic local circuitry using a mouse line for visualizing CRF neurons by a fluorescent protein

Grants-in-Aid for Scientific Research, Grant-in-Aid for Scientific Research (C), Japan Society for the Promotion of Science, Apr, 2014 - Mar, 2017

Itoi Keiichi, WAKAMORI MINORU, SAKIMURA KENJI
Drug-delivery-system through ion channels

Grants-in-Aid for Scientific Research, Grant-in-Aid for Challenging Exploratory Research, Japan Society for the Promotion of Science, Apr, 2013 - Mar, 2015

WAKAMORI Minoru, YOSHIDA Takashi
An investigation of the relationship between occlusion, mastication and mental activity using in vivo patch clamp recording method

Grants-in-Aid for Scientific Research, Grant-in-Aid for Scientific Research (C), Japan Society for the Promotion of Science, 2011 - 2013

TSBUBOI Akito, WAKAMORI Minoru
NETWORK ANALYSIS AMONG HARD TISSUE CELLS USING MULTI-PHOTON MICROSCOPE

Grants-in-Aid for Scientific Research, Grant-in-Aid for Challenging Exploratory Research, Japan Society for the Promotion of Science, 2010 - 2012

WAKAMORI Minoru, NAKAI Jyunichi
Functional analysis of oral sensation on the basis of signalplexes

Grants-in-Aid for Scientific Research, Grant-in-Aid for Scientific Research (B), Japan Society for the Promotion of Science, 2009 - 2011

WAKAMORI Minoru, YOSHIDA Takashi, MORI Yasuo
Mechanism of sensory dysfunction of swallowing in elderly people and its applied regenerative therapy

Grants-in-Aid for Scientific Research, Grant-in-Aid for Scientific Research (B), Japan Society for the Promotion of Science, 2009 - 2011

EBIHARA Satoru, WAKAMORI Minoru
味覚形成における脂質ミクロドメインの役割

科学研究費助成事業, 特定領域研究, 日本学術振興会, 2008 - 2009

若森実
Ca^<2+> channelplexes : assembly in the membrane and physiological significance

Grants-in-Aid for Scientific Research, Grant-in-Aid for Scientific Research on Priority Areas, Japan Society for the Promotion of Science, 2005 - 2009

MORI Yasuo, FUJIMOTO Toyoshi, WAKAMORI Minoru, HARA Yuji
優性及び劣性遺伝形態をとる運動失調症マウスの小脳機能の電気生理学的比較

科学研究費助成事業, 特定領域研究, 日本学術振興会, 2006 - 2007

若森実, 森泰生
小脳失調症の遺伝子、分子、細胞、小脳回路と多次元コンピュテーショナル神経科学

科学研究費助成事業, 特定領域研究, 日本学術振興会, 2005 - 2005

若森実, 森泰生, 原雄二
Elecrtophysiological properties of voltage-gated Ca^<2+> channel and other cation channels.

Grants-in-Aid for Scientific Research, Grant-in-Aid for Scientific Research (C), Japan Society for the Promotion of Science, 2003 - 2004

WAKAMORI Minoru
Functional relationship between Ca^<2+>-dependent cation channel and Ca^<2+>-permeable channel

Grants-in-Aid for Scientific Research, Grant-in-Aid for Scientific Research (C), Japan Society for the Promotion of Science, 2001 - 2002

WAKAMORI Minoru
Dynamic analysis of subcellular ionic signalling in neurons

Grants-in-Aid for Scientific Research, Grant-in-Aid for Scientific Research (B)., Japan Society for the Promotion of Science, 1999 - 2000

IMOTO Keiji, WAKAMORI Minoru, NAKAI Junichi, MORI Yasuo
Electrophysiological study of mutant P-type Ca^<2+> channels causing diseases

Grants-in-Aid for Scientific Research, Grant-in-Aid for Scientific Research (C), Japan Society for the Promotion of Science, 1999 - 2000

WAKAMORI Minoru
Study of electrophysiological properties of cloned N-type Ca^<2+> channel

Grants-in-Aid for Scientific Research, Grant-in-Aid for Scientific Research (C), Japan Society for the Promotion of Science, 1997 - 1998

WAKAMORI Minoru

Profile Information

Research Interests

Research Areas

Research History

Papers

Misc.

Professional Memberships

Research Projects

Menu

Coauthors