2017年9月
ANTIVIRAL ACTIVITIES OF SOME NEW 2,4,6-TRISUBSTITUTED 1,3,5-TRIAZINES HAVING ALKOXY AND/OR ALKYLAMINO GROUPS
HETEROCYCLES
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- 巻
- 94
- 号
- 9
- 開始ページ
- 1653
- 終了ページ
- 1677
- 記述言語
- 英語
- 掲載種別
- 研究論文(学術雑誌)
- DOI
- 10.3987/COM-17-13735
- 出版者・発行元
- PERGAMON-ELSEVIER SCIENCE LTD
We report the preparation of C-3- and C-S-symmetrical 2,4,6-trisubstituted 1,3,5-triazine derivatives having alkoxy and/or alkylamino groups and results of biological evaluation of their anti-herpes simplex virus type 1 (anti-HSV-1) activity and cytotoxic activity against Vero cells. New targeted symmetrical molecules were obtained by using a method starting with 2,4,6-trichloro-1,3,5-triazine (1). Among the synthesized compounds, C-S-symmetrical tri-aliphatic alkylamino-substituted compound 6s showed high anti-HSV-1 activity (EC50 = 5.4 mu M) and low cytotoxicity (CC50 > 200 mu M). The results of an SAR study suggested that the presence of two hydrogen bond donor protons of sec-amine functionality in the molecule is an important structural factor for expression of potential anti-HSV-1 activities.
- リンク情報
- ID情報
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- DOI : 10.3987/COM-17-13735
- ISSN : 0385-5414
- eISSN : 1881-0942
- Web of Science ID : WOS:000411779600002