2020年11月
Human NINEIN polymorphism at codon 1111 is associated with the risk of colorectal cancer.
Biomedical reports
- 巻
- 13
- 号
- 5
- 開始ページ
- 45
- 終了ページ
- 45
- 記述言語
- 掲載種別
- 研究論文(学術雑誌)
- DOI
- 10.3892/br.2020.1352
NINEIN serves an essential role in centrosome function as a microtubule organizing center, and in the reformation of the interphase centrosome architecture following mitosis. In the present study, the association between NINEIN Pro1111Ala (rs2236316), a missense single nucleotide polymorphism, and the risk of colorectal cancer (CRC), related to smoking and alcohol consumption habits in 200 patients with CRC and 1,141 cancer-free control participants were assessed in a case-control study performed in Japan. The results showed that the NINEIN Ala/Ala genotype compared with the Pro/Pro genotype was significantly more associated with an increased risk of CRC, and the males with the Ala/Ala genotype exhibited a significantly increased risk of CRC compared with those with Pro/Pro and Pro/Ala genotypes. Stratified analyses of the Ala/Ala genotype with CRC risk further showed an increased association in never/light drinkers (<23 g of ethanol/day), in male never/light drinkers and in male patients with rectal cancer. These findings suggest that the genetic variant of the NINEIN Pro1111Ala polymorphism has a significant effect on CRC susceptibility in the Japanese population.
- リンク情報
- ID情報
-
- DOI : 10.3892/br.2020.1352
- PubMed ID : 32934817
- PubMed Central 記事ID : PMC7469573