1999年5月
Intrarenal angiotensin converting enzyme inhibition in spontaneously hypertensive rats
EUROPEAN JOURNAL OF PHARMACOLOGY
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- 巻
- 373
- 号
- 1
- 開始ページ
- 35
- 終了ページ
- 40
- 記述言語
- 英語
- 掲載種別
- DOI
- 10.1016/S0014-2999(99)00266-6
- 出版者・発行元
- ELSEVIER SCIENCE BV
We examined the hypotensive effect of enalapril in relation to the local renin-angiotensin system of the kidney in spontaneously hypertensive rats (SHR). Oral administration of enalapril for 7 days decreased mean arterial blood pressure and renal tissue angiotensin II concentration without affecting plasma angiotensin II concentration in SHR. The enalapril treatment did not affect maximum binding of angiotensin II to renal tubules and glomeruli in SHR. In normotensive Wistar-Kyoto rats, no significant changes in mean arterial blood pressure, renal and plasma angiotensin levels were observed with enalapril treatment. Direct infusion of enalapril into the renal medullary interstitium decreased mean arterial blood pressure in association with the reduction of renal tissue angiotensin II concentration without changes in plasma angiotensin II concentration in SHR. These observations suggest that the inhibition of angiotensin conversion in the kidney is important for the hypotensive action of enalapril. (C) 1999 Elsevier Science B.V. All rights reserved.
- リンク情報
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- DOI
- https://doi.org/10.1016/S0014-2999(99)00266-6
- CiNii Articles
- http://ci.nii.ac.jp/naid/80011156875
- PubMed
- https://www.ncbi.nlm.nih.gov/pubmed/10408249
- Web of Science
- https://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=JSTA_CEL&SrcApp=J_Gate_JST&DestLinkType=FullRecord&KeyUT=WOS:000080918300004&DestApp=WOS_CPL
- ID情報
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- DOI : 10.1016/S0014-2999(99)00266-6
- ISSN : 0014-2999
- CiNii Articles ID : 80011156875
- PubMed ID : 10408249
- Web of Science ID : WOS:000080918300004