Yasuyuki Endo

Profile Information

Affiliation: Professor, Faculty of Pharmaceutical Sciences, Department of Pharmaceutical Science, Tohoku Medical and Pharmaceutical University

Degree: Ph D.(The University of Tokyo)

J-GLOBAL ID: 200901040918296999
researchmap Member ID: 5000008884

External link: http://www.tohoku-pharm.ac.jp/laboratory/soyaku/english0.html

Research Interests

Research Areas

Research History

Apr, 2019 - Present

Specially Appointed Professor, Faculty of Pharmaceutical Sciences, Tohoku Medical and Pharmaceutical University
2016 - Mar, 2019

Faculty of Pharmaceutical Sciences, Tohoku Medical and Pharmaceutical University
2002 - 2016

東北薬科大学教授
1992 - 2002

Faculty of Pharmaceutical Sciences, The University of Tokyo
1992 - 2002

Associate Protessor University of Tokyo
1986 - 1992

Faculty of Pharmaceutical Sciences, The University of Tokyo
1986 - 1992

Assistant Professor, University of Tokyo
1980 - 1986

Faculty of Pharmaceutical Sciences, The University of Tokyo
1980 - 1986

Research Associate, University of Tokyo

Education

- 1979

The University of Tokyo
- 1979

Graduate school of Pharmaceutical Sciences, The University of Tokyo
- 1976

Faculty of Pharmaceutical Sciences, The University of Tokyo

Committee Memberships

Mar, 2016 - Mar, 2017

副会頭, 日本薬学会
Mar, 2015 - Mar, 2017

日本薬学会第137年会組織委員長, 日本薬学会
2009 - 2011

理事, 日本薬学会
2008 - 2009

厚生労働省第94回薬剤師国家試験委員長
2003 - 2009

厚生労働省薬剤師国家試験委員
2005

International Commitee, International Conference of Boron Chemistry

Awards

Papers

Challenging Approach to the Development of Novel Estrogen Receptor Modulators Based on the Chemical Properties of Guaiazulene.

Kiminori Ohta, Asako Kaise, Takumi Ogawa, Yasuyuki Endo

International journal of molecular sciences, 23(3), Jan 20, 2022
Development of force field parameters for p-carborane to investigate the structural influence of carborane derivatives on drug targets by complex formation

Koichi Kato, Tomoki Nakayoshi, Hiroki Inoue, Shuichi Fukuyoshi, Kiminori Ohta, Yasuyuki Endo, Eiji Kurimoto, Akifumi Oda

Biological and Pharmaceutical Bulletin, 43(12) 1931-1939, Dec 1, 2020
Antidepressant effect of BE360, a new selective estrogen receptor modulator, activated via CREB/BDNF, Bcl-2 signaling pathways in ovariectomized mice.

Wakana Sakuma, Osamu Nakagawasai, Wataru Nemoto, Takayo Odaira, Takumi Ogawa, Kiminori Ohta, Yasuyuki Endo, Koichi Tan-No

Behavioural brain research, 393 112764-112764, Jun 11, 2020 Peer-reviewed
アンドロゲン受容体とカルボラン誘導体との複合体の分子動力学シミュレーション

金井涼, 加藤紘一, 仲吉朝希, 太田公規, 遠藤泰之, 栗本英治, 小田彰史

日本薬学会年会要旨集, 140年会 28P-am259S, Mar, 2020
Development of Force Field Parameters for p-Carborane to Investigate the Structural Influence of Carborane Derivatives on Drug Targets by Complex Formation.

Koichi Kato, Tomoki Nakayoshi, Hiroki Inoue, Shuichi Fukuyoshi, Kiminori Ohta, Yasuyuki Endo, Eiji Kurimoto, Akifumi Oda

Biological & pharmaceutical bulletin, 43(12) 1931-1939, 2020
Design and Synthesis of Novel Breast Cancer Therapeutic Drug Candidates Based upon the Hydrophobic Feedback Approach of Antiestrogens.

Kiminori Ohta, Asako Kaise, Fumi Taguchi, Sayaka Aoto, Takumi Ogawa, Yasuyuki Endo

Molecules (Basel, Switzerland), 24(21), Nov 1, 2019 Peer-reviewed
ER subtype selectivity of m-carborane-containing phenols: C-alkyl groups on the m-carborane cage enhance ERα selectivity.

Kiminori Ohta, Takumi Ogawa, Koichi Kato, Akifumi Oda, Yasuyuki Endo

Bioorganic & medicinal chemistry letters, 29(16) 2290-2293, Aug 15, 2019 Peer-reviewed
Anti-cancer activity of m-carborane-containing trimethoxyphenyl derivatives through tubulin polymerization inhibition.

Asako Kaise, Yasuyuki Endo, Kiminori Ohta

Bioorganic & medicinal chemistry, 27(6) 1139-1144, Mar 15, 2019 Peer-reviewed
An automated microliter-scale high-throughput screening system (MSHTS) for real-time monitoring of protein aggregation using quantum-dot nanoprobes.

Rina Sasaki, Reina Tainaka, Yuichi Ando, Yurika Hashi, Hadya V Deepak, Yoshiko Suga, Yuta Murai, Masaki Anetai, Kenji Monde, Kiminori Ohta …

Scientific reports, 9(1) 2587-2587, Feb 22, 2019 Peer-reviewed
Novel androgen receptor full antagonists: Design, synthesis, and a docking study of glycerol and aminoglycerol derivatives that contain p-carborane cages

Asako Kaise, Kiminori Ohta, Shinya Fujii, Akifumi Oda, Tokuhito Goto, Yasuyuki Endo

Bioorganic and Medicinal Chemistry, 26(13) 3805-3811, 2018 Peer-reviewed
Novel p-carborane-containing multitarget anticancer agents inspired by the metabolism of 17 beta-estradiol

Asako Kaise, Kiminori Ohta, Yasuyuki Endo

BIOORGANIC & MEDICINAL CHEMISTRY, 25(24) 6371-6378, Dec, 2017 Peer-reviewed
Design and synthesis of p-carborane-containing sulfamates as multitarget anti-breast cancer agents

Asako Kaise, Kiminori Ohta, Chinami Shirata, Yasuyuki Endo

BIOORGANIC & MEDICINAL CHEMISTRY, 25(24) 6417-6426, Dec, 2017 Peer-reviewed
Screening of amyloid-β aggregation inhibitors from aromatic low molecular compounds by a microliter-scale high-throughput screening system with quantam-dot nanoprobes

Y.Ando, K. Ota, I. Ito, H. Kikuchi, Y. Oshima, Y. Endo, K. Uwai, K. Tokuraku

Neuroscience 2017, Nov, 2017
Design and synthesis of iodocarborane-containing ligands with high affinity and selectivity toward ER beta

Kiminori Ohta, Takumi Ogawa, Yasuyuki Endo

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 27(17) 4030-4033, Sep, 2017 Peer-reviewed
Structure-activity relations of rosmarinic acid derivatives for the amyloid beta aggregation inhibition and antioxidant properties

Riho Taguchi, Koki Hatayama, Tomohito Takahashi, Takafumi Hayashi, Yuki Sato, Daisuke Sato, Kiminori Ohta, Hiroto Nakano, Chigusa Seki, Yasuyuki Endo …

EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 138 1066-1075, Sep, 2017 Peer-reviewed
Discovery of lead compounds targeting Amyloid-β aggregation from aromatic low-molecular compounds

Yuichi Ando, Kiminori Ota, Ikuko Ito, Haruhisa Kikuchi, Yoshiteru Oshima, Yasuyuki Endo, Koji Uwai, Kiyotaka Tokuraku

Joint Seminar on Environmental Science and Disaster Mitigation Research 2017, 83-84, Mar, 2017
Design, synthesis, and anti-proliferative activity of 1-(4-methoxyphenyl)-12-hydroxymethyl-p-carborane derivatives

Asako Kaise, Kiminori Ohta, Yasuyuki Endo

EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 122 257-263, Oct, 2016 Peer-reviewed
BA321, a novel carborane analog that binds to androgen and estrogen receptors, acts as a new selective androgen receptor modulator of bone in male mice

Kenta Watanabe, Michiko Hirata, Tsukasa Tominari, Chiho Matsumoto, Yasuyuki Endo, Gillian Murphy, Hideaki Nagase, Masaki Inada, Chisato Miyaura

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 478(1) 279-285, Sep, 2016 Peer-reviewed
Symmetric 4,4 '-(piperidin-4-ylidenemethylene)bisphenol derivatives as novel tunable estrogen receptor (ER) modulators

Manabu Sato, Kiminori Ohta, Asako Kaise, Sayaka Aoto, Yasuyuki Endo

BIOORGANIC & MEDICINAL CHEMISTRY, 24(5) 1089-1094, Mar, 2016 Peer-reviewed
Targeting Cancer with PCPA-Drug Conjugates: LSD1 Inhibition-Triggered Release of 4-Hydroxytamoxifen

Yosuke Ota, Yukihiro Itoh, Asako Kaise, Kiminori Ohta, Yasuyuki Endo, Mitsuharu Masuda, Yoshihiro Sowa, Toshiyuki Sakai, Takayoshi Suzuki

Angewandte Chemie - International Edition, 55(52) 16115-16118, 2016 Peer-reviewed

Misc.

175

Molecular dynamics simulations of complexes of androgen receptor and carborane derivatives

金井涼, 加藤紘一, 加藤紘一, 仲吉朝希, 太田公規, 遠藤泰之, 栗本英治, 小田彰史

日本薬学会年会要旨集(CD-ROM), 140th (Web), 2020
更年期障害モデルマウスのうつ状態に対する新規選択的エストロゲン受容体モジュレーターBE360の効果

佐久間若菜, 中川西修, 根本亙, 八百板富紀枝, 小川卓巳, 太田公規, 遠藤泰之, 丹野孝一

生体機能と創薬シンポジウム要旨集, 2016 84, 2016
Determination of AMBER force field parameters for carborane moiety using quantum chemical calculations

Oda Akifumi, Ohta Kiminori, Endo Yasuyuki, Fukuyoshi Shuichi

Proceedings of the Symposium on Chemoinformatics, 2014 P02-P02, 2014
嗅球摘出マウスのうつ様行動に対する新規化合物BE360の改善効果

中川西修, 佐々木俊裕, 斎藤智恵, 深澤鈴, 星杏奈, 根本亙, 八百板富紀枝, 小川卓巳, 太田公規, 遠藤泰之 …

生体機能と創薬シンポジウム要旨集, 2013 95, 2013
ホウ素クラスターを用いた実践的創薬研究

太田公規, 遠藤泰之

ファルマシア, 48(6) 504-508, 2012 Peer-reviewed
Development of novel androgen antagonists based on hydrophobic boron clusters

Fujii, S, Yamada, A, Ohta, K, Endo, Y, Kagechika, H

Drugs of the Future, 35 Suppl.A 258-259, 2010
タモキシフェン代謝におけるCYP2D6バリアント酵素の機能解析

作山佳奈子, 佐々木崇光, 太田公規, 遠藤泰之, 石川正明, 平塚真弘

臨床薬理, 40(Suppl.) S185-S185, Nov, 2009
Development of androgen receptor ligands by using carborane as novel hydrophobic pharmacophore

Fujii, S, Endo, Y, Kagechika, H

Annual Reportes of the Institute of Biomaterials and Bioengineering, 2008(42) 51-54, 2009
A NEW CHIRAL SYNTHESIS OF A BICYCLIC ENEDIONE CONTAINING A SEVEN-MEMBERED RING MEDIATED BY A COMBINATION OF CHIRAL AMINE AND BRONSTED ACID

Takashi Nagamine, Kohei Inomata, Yasuyuki Endo

HETEROCYCLES, 76(2) 1191-1204, Nov, 2008
Carborane BE360, One of the Carbon-Containing Polyhedral Boron-Cluster Compounds, Is a New Type of Selective Estrogen Receptor Modulator.

M. Inada, T. Tominari, M. Hirata, C. Matsumoto, M. Takita, Y. Endo, C. Miyaura

JOURNAL OF BONE AND MINERAL RESEARCH, 23 S286-S286, Sep, 2008
Solid-state supramolecular array through cooperative pi-pi interactions of 1-(2-methoxyphenyl)-o-carborane

Kiminori Ohta, Hiroto Yamazaki, Fabio Pichierri, Masatoshi Kawahata, Kentaro Yamaguchi, Yasuyuki Endo

TETRAHEDRON, 63(49) 12160-12165, Dec, 2007
Enantioselective intramolecular aldol reaction mediated by a combination of L-amino acid and Bronsted acid to construct a bicyclic enedione containing a 7-membered ring

Takashl Nagamine, Kohei Inomata, Yasuyuki Endo

CHEMICAL & PHARMACEUTICAL BULLETIN, 55(12) 1710-1712, Dec, 2007
Development of novel non-seco-steroidal vitamin D derivatives

Hiroyuki Kagechika, Kyoko Yaguchi, Chalermkiat Songkram, Guang Sun, Tomoya Hirano, Aya Tanatani, Yasuyuki Endo

DRUGS OF THE FUTURE, 32 56-57, Jul, 2007
Potent androgen antagonists based on carborane as a hydrophobic core structure

Shinya Fujii, Kiminori Ohta, Tokuhito Goto, Yuichi Hashimoto, Tomoharu Suzuki, Sigeru Ohta, Yasuyuki Endo

DRUGS OF THE FUTURE, 32 105-106, Jul, 2007
Proton-driven conformational change in a 2-aryl-p-carborane constrained by an intramolecular C-H center dot center dot center dot O hydrogen bond

Kiminori Ohta, Hiroto Yamazaki, Masatoshi Kawahata, Kentaro Yamaguchi, Fabio Pichierri, Yasuyuki Endo

TETRAHEDRON LETTERS, 48(30) 5231-5234, Jul, 2007
Facile and efficient synthesis of C-hydroxycarboranes and C,C '-dihydroxycarboranes

Kiminori Ohta, Tokuhito Goto, Hiroto Yamazaki, Fabio Pichierri, Yasuyuki Endo

INORGANIC CHEMISTRY, 46(10) 3966-3970, May, 2007
1-IV-1 新規non-seco-ステロイド型ビタミンD誘導体の創製(ビタミン学の原点・栄養学への21世紀的回帰, 日本ビタミン学会第59回大会)

影近弘之, 谷口京子, Songkram Chalermkiat, 孫光, 平野智也, 河内恵美子, 棚谷綾, 吉見友弘, 遠藤泰之

ビタミン, 81(4) 151-151, Apr 25, 2007
Chemistry of boron clusters, carboranes synthesis, structure and application for molecular construction

Kiminori Ohta, Yasuyuki Endo

JOURNAL OF SYNTHETIC ORGANIC CHEMISTRY JAPAN, 65(4) 320-333, Apr, 2007
ホウ素クラスター：カルボランの有機化学―合成、構造、立体分子構築への応用

有機合成化学協会誌, 65: 320-333, 2007
An alternative chiral synthesis of Wieland-Miescher ketone mediated by (S)-2-(pyrrolidinylmethyl)pyrrolidine: Remarkable effects of bronsted acid

Yuichi Akahane, Naoko Inage, Takashi Nagamine, Kohei Inomata, Yasuyuki Endo

HETEROCYCLES, 74 637-648, 2007

Books and Other Publications

Utility of Boron Cluster for Drug Design: Selective Estrogen Receptor Modulators (SERMs) Bearing Carborane As a Hydrophobic Skeletal Structure., “Boron Chemistry at the Beginning of the 21th century”, Bubnov, Yu., et al (eds.)

Russian Academy of Sciences, Nauka, Moscow, p298-306, 2003
受容体構造とシグナル伝達「メディシナルケミストリー」（北川勲他編訳）

丸善（東京）, 2003
Polyboranes in Medicinal Chemistry. “Molecular Clusters of the Main-Group Elements”, Driess, M.; Noth, H (eds.)

Wiley-VHC, Weinheim, 2003
Polyboranes in Medicinal Chemistry. “Molecular Clusters of the Main-Group Elements”, Driess, M.; Noth, H (eds.)

Wiley-VHC, Weinheim, 2003
A New Medicinal Application of Boron Clusters. Potent Nuclear Receptor Ligands Bearing Carborane as a Hydrophobic Pharmacophore

"Contemporary Boron Chemistry", Wade, K., et al (eds.), the Royal Society of Chemistry, Cambridge Science Press, Cambridge, 2000
A New Medicinal Application of Boron Clusters. Potent Nuclear Receptor Ligands Bearing Carborane as a Hydrophobic Pharmacophore

"Contemporary Boron Chemistry", Wade, K., et al (eds.), the Royal Society of Chemistry, Cambridge Science Press, Cambridge, 2000
発癌プロモーター、テレオシジンの化学と生物活性

発癌と制癌の化学廣川書店（東京）, 1990
New Classes of Tumor Promoters: Teleocidin Aplysiatoxin and Palyioxin

"Cellular Interactions by Enviroumental Tumor promoters" Fujiki, H., et al (eds.), Japan Sci. Soc. Press, Tokyo/ VNU Science Press, Utrecht, 1984
New Classes of Tumor Promoters: Teleocidin Aplysiatoxin and Palyioxin

"Cellular Interactions by Enviroumental Tumor promoters" Fujiki, H., et al (eds.), Japan Sci. Soc. Press, Tokyo/ VNU Science Press, Utrecht, 1984

Professional Memberships

Works

Research Projects

Middle up and down type medicinal chemistry based upon boron compound library

Grants-in-Aid for Scientific Research, Grant-in-Aid for Scientific Research (C), Japan Society for the Promotion of Science, Apr, 2015 - Mar, 2020

Ohta Kiminori
A New Development of Molecular Design Utilizing Novel Hydrophobic Structures

Grants-in-Aid for Scientific Research, Grant-in-Aid for Scientific Research (C), Japan Society for the Promotion of Science, Apr, 2014 - Mar, 2018

ENDO Yasuyuki, TAN-NO Koichi, NAKAGAWASAI Osamu
Development of Receptor Regulators Utilizing Novel HydrophobicStructure and Its Application for Medicinal Drug Design

Grants-in-Aid for Scientific Research, Grant-in-Aid for Scientific Research (B), Japan Society for the Promotion of Science, 2008 - 2012

ENDO Yasuyuki, INOMATA Kohei, OHTA Kiminori, KAGECHIKA Hiroyuki, FUJII Shinya, FABIO Pichierri
Development and Application of Novel 3-Dimensional Hydrophobic Structures for Drug Design, Which Are Focused on Molecular Recognition between Ligand and Receptor

Grants-in-Aid for Scientific Research, Grant-in-Aid for Scientific Research (B), Japan Society for the Promotion of Science, 2004 - 2007

ENDO Yasuyuki, INOMATA Kohei, OHTA Kiminori
Design and development of biological response modifiers

Grants-in-Aid for Scientific Research, Grant-in-Aid for Scientific Research (S), Japan Society for the Promotion of Science, 2002 - 2006

HASHIMOTO Yuichi, MIYACHI Hiroyuki, TANATANI Aya, NAGASAWA Kazuo, ENDO Yasuyuki, KAGECHIKA Hiroyuki
がん増悪因子を阻害する医薬リードの創製

科学研究費助成事業, 特定領域研究, 日本学術振興会, 2002 - 2004

橋本祐一, 小林久芳, 長澤和夫, 遠藤泰之, 小磯邦子
Study on Electronic and Steric Effects of Boron Cluster and Application for Construction of Functional Molecules.

Grants-in-Aid for Scientific Research, Grant-in-Aid for Scientific Research (B), Japan Society for the Promotion of Science, 2001 - 2003

ENDO Yasuyuki, OHTA Kiminori, INOMATA Kohei
Design and Synthesis of Cellular Signal Transduction Modulator, Benzolactam Derivatives and Related Compounds

Grants-in-Aid for Scientific Research, Grant-in-Aid for Scientific Research (B)., Japan Society for the Promotion of Science, 1998 - 2000

ENDO Yasuyuki
医薬分子設計

1998
Medicinal Molecular Design

1998
Design, Synthesis and Biological Activity of Anti-HIV Compounds Derived from Teleocidins

Grants-in-Aid for Scientific Research, Grant-in-Aid for Scientific Research (B), Japan Society for the Promotion of Science, 1995 - 1997

ENDO Yasuyuki, KAGECHIKA Hiroyuki
ヘテロ原子間結合の開裂による[3,3]シグマトロピック転位反応の新展開

科学研究費助成事業, 基盤研究(C), 日本学術振興会, 1996 - 1996

遠藤泰之
発癌プロモーターの活性発現構造解析を目指す分子設計と合成

科学研究費助成事業, 一般研究(C), 日本学術振興会, 1995 - 1995

遠藤泰之
Development of New Methoda for Lead Discovery Using Computer

Grants-in-Aid for Scientific Research, Grant-in-Aid for Developmental Scientific Research (B), Japan Society for the Promotion of Science, 1994 - 1995

ITAI Akiko, TOMIOKA Nobuo, ENDO Yasuyuki, IWAI Yuzuru
Structural Studies on Reactive Complexes for Highly Selective Organic Reactions

Grants-in-Aid for Scientific Research, Grant-in-Aid for Developmental Scientific Research (B), Japan Society for the Promotion of Science, 1994 - 1995

ODASHIMA Kazunori, IMANARI Mamoru, HIGUCHI Tsunehiko, SODEOKA Mikiko, NOGUCHI Hiroshi, ENDO Yasuyuki
核内情報伝達系の制御分子の合成と制がん作用機構

科学研究費助成事業, 重点領域研究, 日本学術振興会, 1994 - 1995

首藤紘一, 影近弘之, 遠藤泰之
Regulatory compound of nuclear receptor functions.

Grants-in-Aid for Scientific Research, Grant-in-Aid for Developmental Scientific Research (B), Japan Society for the Promotion of Science, 1993 - 1995

SHUDO Koichi, KAGECHIKA Hiroyuki
分子設計と合成による発癌プロモーターの活性発現構造の一般性の確立

科学研究費助成事業, 一般研究(C), 日本学術振興会, 1994 - 1994

遠藤泰之
Search for New Tumor Promoters Employing Chemical Calculation

Grants-in-Aid for Scientific Research, Grant-in-Aid for General Scientific Research (C), Japan Society for the Promotion of Science, 1992 - 1993

ENDO Yasuyuki
Participation of di- and tri-cations in Friedel-Crafts reactions.

Grants-in-Aid for Scientific Research, Grant-in-Aid for General Scientific Research (B), Japan Society for the Promotion of Science, 1991 - 1992

SHUDO Koichi, OHWADA Tomo, ENDO Yasuyki

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