Arawaka Shigeki

Profile Information

Affiliation: Professor, Department of INternal Medicine IV, Division of Neurology, Osaka Medical and Pharmaceutical University

Degree: 博士(山形大学)

Researcher number: 00344789
J-GLOBAL ID: 200901047947859530
researchmap Member ID: 5000013710

External link: https://www.osaka-med.ac.jp/class/in4.html

Research Interests

Research Areas

Life sciences / Neurology / Pathological Nueroscience

Research History

Apr, 2017 - Present

Professor, Department of Internal Medicine IV, Division of Neurology, Osaka Medical and Pharmaceutical University
Oct, 2016 - Mar, 2017

Associate Professor, Department of Neurology, Hematology, Metabolism, Endocrinology and Diabetology, Yamagata University Faculty of Medicine
Apr, 2010 - Sep, 2016

Lecturer, Department of Neurology, Hematology, Metabolism, Endocrinology and Diabetology, Yamagata University Faculty of Medicine
Apr, 2007 - Mar, 2010

Research Associate, Department of Neurology, Hematology, Metabolism, Endocrinology and Diabetology, Yamagata University Faculty of Medicine
Apr, 2002 - Mar, 2007

Research Associate, Department of Neurology, Hematology, Metabolism, Endocrinology and Diabetology, Yamagata University Faculty of Medicine
Jun, 1999 - Mar, 2002

Postdoctoral Fellow, Centre for Research in Neurodegenerative Diseases, University of Toronto
Jul, 1998 - May, 1999

Research Fellow, Department of Neuroscience, Osaka City University Medical School
Apr, 1997 - Jun, 1998

Research Fellow, Department of Molecular Biology, Tokyo Institute of Psychiatry

Education

Apr, 1985 - Mar, 1991

Faculty of Medicine, Yamagata University

Committee Memberships

Nov, 2022 - Present

councillor, Japan Society for Dementia Research
2022 - Present

councillor, Movement Disorder Society of Japan
May, 2019 - Present

代議員, 日本神経学会
Apr, 2018 - Present

評議員, 日本内科学会
2017 - Present

評議員, 日本神経治療学会

Major Papers

White Matter Hyperintensities as a Risk Factor for Ischemic Stroke in Patients With Systemic Lupus Erythematosus

Eri Sano, Shigeki Arawaka

Frontiers in Neurology, 12, Dec 13, 2021 Peer-reviewedCorresponding author
Whole-exome sequencing and human leukocyte antigen analysis in familial myasthenia gravis with thymoma: Case report and literature review

Yoshitsugu Nakamura, Hidenori Sato, Yuki Miyano, Ryoko Murakami, Mikiko Motoki, Taro Shigekiyo, Masakazu Sugino, Shigeki Arawaka

Clinical Neurology and Neurosurgery, 208 106864-106864, Sep, 2021 Peer-reviewedCorresponding author
Monoamine oxidase-B inhibition facilitates α-synuclein secretion in vitro and delays its aggregation in rAAV-based rat models of Parkinson's disease.

Yoshitsugu Nakamura, Shigeki Arawaka, Hiroyasu Sato, Asuka Sasaki, Taro Shigekiyo, Kazue Takahata, Hiroko Tsunekawa, Takeo Kato

The Journal of neuroscience : the official journal of the Society for Neuroscience, Jul 21, 2021 Peer-reviewedCorresponding author
Assessment of clinical factors affecting outcome of myasthenia gravis.

Yukiyo Yoshimoto, Shimon Ishida, Takafumi Hosokawa, Shigeki Arawaka

Muscle & nerve, 64(1) 90-94, Jul, 2021 Peer-reviewedCorresponding author
Laterality of specific binding ratios on DAT-SPECT for differential diagnosis of degenerative parkinsonian syndromes.

Taro Shigekiyo, Shigeki Arawaka

Scientific reports, 10(1) 15761-15761, Sep 25, 2020 Peer-reviewedCorresponding author
Fulminant Guillain-Barré syndrome showing severe pharyngeal-cervical-brachial weakness in the recovery phase: a case report.

Yoshitsugu Nakamura, Mikiko Motoki, Takahiko Hirose, Takafumi Hosokawa, Shimon Ishida, Shigeki Arawaka

BMC neurology, 19(1) 145-145, Jun 28, 2019 Peer-reviewedCorresponding author
Mechanisms underlying extensive Ser129-phosphorylation in alpha-synuclein aggregates

Shigeki Arawaka, Hiroyasu Sato, Asuka Sasaki, Shingo Koyama, Takeo Kato

ACTA NEUROPATHOLOGICA COMMUNICATIONS, 5(1) 48, Jun, 2017 Peer-reviewedLead authorCorresponding author
A Segmental Copy Number Loss of the SFMBT1 Gene Is a Genetic Risk for Shunt-Responsive, Idiopathic Normal Pressure Hydrocephalus (iNPH): A Case-Control Study

Hidenori Sato, Yoshimi Takahashi, Luna Kimihira, Chifumi Iseki, Hajime Kato, Yuya Suzuki, Ryosuke Igari, Hiroyasu Sato, Shingo Koyama, Shigeki Arawaka …

PLOS ONE, 11(11), Nov, 2016 Peer-reviewed
Sensitive western blotting for detection of endogenous Ser129-phosphorylated alpha-synuclein in intracellular and extracellular spaces

Asuka Sasaki, Shigeki Arawaka, Hiroyasu Sato, Takeo Kato

SCIENTIFIC REPORTS, 5 14211, Sep, 2015 Peer-reviewedCorresponding author
Potential of Cellular and Animal Models Based on a Prion-Like Propagation of alpha-Synuclein for Assessing Antiparkinson Agents

Hiroyasu Sato, Takeo Kato, Shigeki Arawaka

MOLECULAR NEUROBIOLOGY, 52(1) 226-235, Aug, 2015 Peer-reviewedCorresponding author
Zonisamide Attenuates alpha-Synuclein Neurotoxicity by an Aggregation-Independent Mechanism in a Rat Model of Familial Parkinson's Disease

Shigeki Arawaka, Shingo Fukushima, Hiroyasu Sato, Asuka Sasaki, Kaori Koga, Shingo Koyama, Takeo Kato

PLOS ONE, 9(2) e89076, Feb, 2014 Peer-reviewedLead authorCorresponding author
Serine 129 phosphorylation of membrane-associated alpha-synuclein modulates dopamine transporter function in a G protein-coupled receptor kinase-dependent manner

Susumu Hara, Shigeki Arawaka, Hiroyasu Sato, Youhei Machiya, Can Cui, Asuka Sasaki, Shingo Koyama, Takeo Kato

MOLECULAR BIOLOGY OF THE CELL, 24(11) 1649-1660, Jun, 2013 Peer-reviewedCorresponding author
The role of Ser129 phosphorylation of alpha-synuclein in neurodegeneration of Parkinson's disease: a review of in vivo models

Hiroyasu Sato, Takeo Kato, Shigeki Arawaka

REVIEWS IN THE NEUROSCIENCES, 24(2) 115-123, Apr, 2013 Peer-reviewedCorresponding author
Authentically Phosphorylated alpha-Synuclein at Ser129 Accelerates Neurodegeneration in a Rat Model of Familial Parkinson's Disease

Hiroyasu Sato, Shigeki Arawaka, Susumu Hara, Shingo Fukushima, Kaori Koga, Shingo Koyama, Takeo Kato

JOURNAL OF NEUROSCIENCE, 31(46) 16884-16894, Nov, 2011 Peer-reviewedCorresponding author
Phosphorylated alpha-Synuclein at Ser-129 Is Targeted to the Proteasome Pathway in a Ubiquitin-independent Manner

Youhei Machiya, Susumu Hara, Shigeki Arawaka, Shingo Fukushima, Hiroyasu Sato, Masahiro Sakamoto, Shingo Koyama, Takeo Kato

JOURNAL OF BIOLOGICAL CHEMISTRY, 285(52) 40732-40744, Dec, 2010 Peer-reviewedCorresponding author
Contribution of endogenous G-protein-coupled receptor kinases to Ser129 phosphorylation of alpha-synuclein in HEK293 cells

Masahiro Sakamoto, Shigeki Arawaka, Susumu Hara, Hiroyasu Sato, Can Cui, Youhei Machiya, Shingo Koyama, Manabu Wada, Toru Kawanami, Keiji Kurita …

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 384(3) 378-382, Jul, 2009 Peer-reviewedCorresponding author
N-terminal region of alpha-synuclein is essential for the fatty acid-induced oligomerization of the molecules

Hiroki Karube, Masahiro Sakamoto, Shigeki Arawaka, Susumu Hara, Hiroyasu Sato, Chang-Hong Ren, Saori Goto, Shingo Koyama, Manabu Wada, Toru Kawanami …

FEBS LETTERS, 582(25-26) 3693-3700, Oct, 2008 Peer-reviewedCorresponding author
The role of G-protein-coupled receptor kinase 5 in pathogenesis of sporadic Parkinson's disease.

Shigeki Arawaka, Manabu Wada, Saori Goto, Hiroki Karube, Masahiro Sakamoto, Chang-Hong Ren, Shingo Koyama, Hikaru Nagasawa, Hideki Kimura, Toru Kawanami …

The Journal of neuroscience : the official journal of the Society for Neuroscience, 26(36) 9227-38, Sep 6, 2006 Peer-reviewedLead author
The levels of, mature glycosylated nicastrin are regulated and correlate with gamma-secretase processing of amyloid beta-precursor protein

S Arawaka, H Hasegawa, A Tandon, C Janus, FS Chen, G Yu, K Kikuchi, S Koyama, T Kato, PE Fraser …

JOURNAL OF NEUROCHEMISTRY, 83(5) 1065-1071, Dec, 2002 Peer-reviewedLead author
A founder mutation in presenilin 1 causing early-onset Alzheimer disease in unrelated Caribbean Hispanic families

ES Athan, J Williamson, A Ciappa, Santana, V, SN Romas, JH Lee, H Rondon, RA Lantigua, M Medrano, M Torres …

JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION, 286(18) 2257-2263, Nov, 2001 Peer-reviewed
Nicastrin binds to membrane tethered Notch

FS Chen, G Yu, S Arawaka, M Nishimura, T Kawarai, H Yu, A Tandon, A Supala, YQ Song, E Rogaeva …

NATURE CELL BIOLOGY, 3(8) 751-754, Aug, 2001 Peer-reviewed
Nicastrin modulates presenilin-mediated notch/glp-1 signal transduction and beta APP processing

G Yu, M Nishimura, S Arawaka, D Levitan, LL Zhang, A Tandon, YQ Song, E Rogaeva, FS Chen, T Kawaral …

NATURE, 407(6800) 48-54, Sep, 2000 Peer-reviewed
Deposition of beta-amyloid subtypes 40 and 42 differentiates dementia with Lewy bodies from Alzheimer disease

CF Lippa, K Ozawa, DMA Mann, K Ishii, TW Smith, S Arawaka, H Mori

ARCHIVES OF NEUROLOGY, 56(9) 1111-1118, Sep, 1999 Peer-reviewed
The tau mutation (val337met) disrupts cytoskeletal networks of microtubules

S Arawaka, M Usami, N Sahara, GD Schellenberg, G Lee, H Mori

NEUROREPORT, 10(5) 993-997, Apr, 1999 Peer-reviewedLead author
Lewy body in neurodegeneration with brain iron accumulation type 1 is immunoreactive for alpha-synuclein

S Arawaka, Y Saito, S Murayama, H Mori

NEUROLOGY, 51(3) 887-889, Sep, 1998 Peer-reviewedLead author
A novel autoantibody in paraneoplastic sensory-dominant neuropathy reacts with brain-type creatine kinase

S Arawaka, M Daimon, H Sasaki, JI Suzuki, T Kato

INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE, 1(3) 597-600, Mar, 1998 Peer-reviewedLead author
A novel autoantibody in paraneoplastic sensory-dominant neuropathy

S Arawaka, T Kato, K Kurita, M Daimon, N Matsumoto, H Sasaki

NEUROPATHOLOGY, 17(2) 89-93, Jun, 1997 Peer-reviewedLead author

Misc.

176

α-シヌクレイン細胞外分泌におけるMAO-B阻害薬の効果の細胞生物学的解析

中村善胤, 荒若繁樹

パーキンソン病・運動障害疾患コングレスプログラム・抄録集, 14回 95-95, Feb, 2021
MRIで両下肢筋に信号変化を呈した腰部脊柱管狭窄症の3例

細川隆史, 小川将司, 元木三記子, 吉本幸世, 増田裕一, 佐野恵理, 中村善胤, 重清太郎, 塚原彰弘, 太田真 …

臨床神経学, 60(Suppl.) S369-S369, Nov, 2020
高齢発症のcryptococcus髄膜炎における頭部MRI所見の経時的観察

石田志門, 元木三記子, 増田裕一, 重清太郎, 太田真, 山根一志, 荒若繁樹

臨床神経学, 60(Suppl.) S456-S456, Nov, 2020
サルコイドーシスに類似した抗ミトコンドリアM2抗体陽性筋炎の1例

小川将司, 中村善胤, 太田真, 山根一志, 細川隆史, 石田志門, 西野一三, 荒若繁樹

臨床神経学, 59(12) 848-848, Dec, 2019
SLEにおけるMRI大脳白質病変と脳梗塞発症の関連についての検討

佐野恵理, 谷裕基, 永井孝治, 細川隆史, 石田志門, 武内徹, 荒若繁樹

臨床神経学, 59(Suppl.) S235-S235, Nov, 2019
MPO-ANCA関連血管炎における脳小血管病の有病率と進行性

谷裕基, 永井孝治, 佐野恵理, 細川隆史, 石田志門, 荒若繁樹

臨床神経学, 59(Suppl.) S278-S278, Nov, 2019
細菌性髄膜炎と化膿性脊椎炎を併発した3例の臨床的検討

細川隆史, 澤井大樹, 堀はるか, 宮川るみな, 中村善胤, 重清太郎, 佐野恵理, 塚原彰弘, 太田真, 谷裕基 …

臨床神経学, 59(Suppl.) S286-S286, Nov, 2019
脳梗塞を契機に発見された神経梅毒の臨床像の検討

重清太郎, 中村善胤, 宇野田喜一, 細川隆史, 石田志門, 荒若繁樹

臨床神経学, 59(Suppl.) S287-S287, Nov, 2019
トルーソー症候群と心原性脳塞栓症での入院時の凝固線溶系の比較検討

堀はるか, 宇野田喜一, 澤井大樹, 宮川るみな, 塚原彰弘, 山根一志, 細川隆史, 石田志門, 荒若繁樹, 木村文治

臨床神経学, 59(Suppl.) S347-S347, Nov, 2019
パーキンソン病における夜間不眠についての検討

石田志門, 宇野田喜一, 山根一志, 細川隆史, 杉野正一, 木村文治, 荒若繁樹

臨床神経学, 59(Suppl.) S355-S355, Nov, 2019
サルコイドーシスに類似した抗ミトコンドリアM2抗体陽性筋炎の1例

中村善胤, 小川将司, 太田真, 山根一志, 細川隆史, 石田志門, 西野一三, 荒若繁樹

神経治療学, 36(6) S277-S277, Oct, 2019
パーキンソン病の病態解明と治療法の進歩

荒若繁樹

大阪医科大学雑誌, 78(1-2) 85-86, Sep, 2019
MRI拡散強調画像で両側大脳白質に高信号域を呈した敗血症性脳症の1例

細川隆史, 澤井大樹, 佐野恵理, 石田志門, 荒若繁樹

NEUROINFECTION, 24(2) 166-166, Sep, 2019
ニボルマブ投与後に発症した筋炎合併重症筋無力症の1剖検例

澤井大樹, 細川隆史, 重清太郎, 小川将司, 佐野恵理, 荒若繁樹

臨床神経学, 59(6) 360-364, Jun, 2019
関節リウマチの合併症関節リウマチ合併間質性肺疾患の治療に関する検討

庄田武司, 武内徹, 永井孝治, 秦健一郎, 松村洋子, 吉川紋佳, 小谷卓矢, 槇野茂樹, 荒若繁樹

日本リウマチ学会総会・学術集会プログラム・抄録集, 63回 458-458, Mar, 2019
リウマチ性疾患の基礎研究-3 ブレオマイシン誘発間質性肺炎モデルマウスに対する低分子量ヘパリンPLGA徐放粒子を用いた治療効果の検討

小谷卓矢, 鈴鹿隆保, 松田翔悟, 木坊子貴生, 永井孝治, 秦健一郎, 武内徹, 荒若繁樹

日本リウマチ学会総会・学術集会プログラム・抄録集, 63回 519-519, Mar, 2019
当院における間質性肺疾患合併関節リウマチに対するゴリムマブの使用経験

斯波秀行, 永井孝治, 松田翔悟, 木坊子貴生, 吉川紋佳, 石田貴昭, 藤木陽平, 秦健一郎, 庄田武司, 小谷卓矢 …

日本リウマチ学会総会・学術集会プログラム・抄録集, 63回 674-674, Mar, 2019
抗MDA5抗体迅速検査が診断と治療方針の決定に有用であった皮膚筋炎合併間質性肺炎の1例

久保山知彦, 藤木陽平, 小谷卓矢, 永井孝治, 秦健一郎, 武内徹, 荒若繁樹

日本リウマチ学会総会・学術集会プログラム・抄録集, 63回 766-766, Mar, 2019
右下腿の色素沈着を主訴に受診した筋膜脂肪織炎症候群の一例

辻野晃平, 松田翔悟, 藤木陽平, 宮川るみな, 塚原彰弘, 永井孝治, 秦健一郎, 小谷卓矢, 武内徹, 荒若繁樹

日本リウマチ学会総会・学術集会プログラム・抄録集, 63回 824-824, Mar, 2019
病理学的に脂肪織炎のみを認めた筋膜脂肪織炎症候群の2例

宮川るみな, 元木三記子, 吉本幸世, 佐野恵理, 宇野田喜一, 石田志門, 中嶋秀人, 木村文治, 荒若繁樹

臨床神経学, 58(Suppl.) S277-S277, Dec, 2018

Books and Other Publications

高齢者における神経変性疾患

荒若繁樹, 加藤丈夫 (Role: Contributor, 筋萎縮性側索硬化症の病態と治療の展望)

ライフ・サイエンス, 2016
遺伝子・再生医療研究から学ぶパーキンソン病

荒若繁樹, 加藤丈夫 (Role: Contributor, α-synuclein(PARK1/4)機能における翻訳後修飾の役割－リン酸化研究の現状)

医歯薬出版, 2013
図説分子病態学第5版

荒若繁樹, 加藤丈夫 (Role: Contributor, パーキンソン病)

中外医学社
内科学書第8版

荒若繁樹, 加藤丈夫

中山書店

Professional Memberships

Research Projects

Analysis of novel mechanisms of tau extracellular secretion for causing cognitive impairments in Parkison's disease

Grants-in-Aid for Scientific Research Grant-in-Aid for Scientific Research (C), Grant-in-Aid for Scientific Research (C), Japan Society for the Promotion of Science, Apr, 2022 - Mar, 2025
オートファジー制御因子Beclin 1を標的としたαシヌクレイン神経毒性緩和効果

科研費基盤（c）, 日本学術振興会, Apr, 2019 - Mar, 2022

荒若繁樹
アデノシンA2a受容体ノックアウトによるα-シヌクレイン神経毒性緩和機序の解明.

科研費基盤研究（c）, 日本学術振興会, Apr, 2015 - Mar, 2018

荒若繁樹
パーキンソン病治療標的としてのα-シヌクレイン発現抑制のin vivo解析.

科研費基盤研究（c）, 日本学術振興会, Apr, 2011 - Mar, 2014

荒若繁樹
パーキンソン病治療標的としてのリン酸化αシヌクレインの生物学的解析.

科研費基盤研究（c）, 日本学術振興会, Apr, 2007 - Mar, 2009

荒若繁樹
変異型SOD１の重合体形成についての細胞生物学的解析.

特定領域研究(先端脳), 文部科学省, Apr, 2004 - Mar, 2005

荒若繁樹
Notch S3部位の切断に関与するプレセニリン高分子複合体構成因子について.

科研費若手研究(B), 日本学術振興会, Apr, 2003 - Mar, 2005

荒若繁樹
γセクレターゼにおけるニカストリンとプレセニリン相互作用の細胞生物学的解析

特定領域研究(先端脳), 文部科学省, Apr, 2003 - Mar, 2004

荒若繁樹

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Research History

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Major Papers

Misc.

Books and Other Publications

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