Toru Ishizuka - My portal

Profile Information

Affiliation: Lecturer, Tohoku University

J-GLOBAL ID: 200901074007554259
researchmap Member ID: 5000025862

External link: http://db.tohoku.ac.jp/whois/e_detail/c7717666ed0fec64c797370841db5c66.html

Research Interests

Research Areas

Life sciences / Neuroscience - general /

Awards

Jul, 2018

5th Biophysics and Physicobioloby Editors' Choice Award, Kinetic characterization of chimeric channelrhodopsins implicate the molecular identity involved in desensitization, Biophysics and Physicobiology, Vol 14, p13-22, 2017, The Biophysical Society of Japan

ZAMANI Alemeh, SAKURAGI Shigeo, ISHIZUKA Toru, YAWO Hiromu
May, 2010

日本生理学会入澤記念JPS優秀論文賞, β-Phorbol ester-induced enhancement of exocytosis in large mossy fiber boutons of mouse hippocampus, 日本生理学会

引間卓弥, 荒木力太, 石塚徹, 八尾寛
May, 2006

第３回東北大学バイオサイエンスシンポジウムポスター賞, 神経ネットワークの解析のための光を用いた神経細胞の機能計測・刺激技術, 東北大学

石塚徹, 荒木力太, 引間卓弥, 角田雅昭, 鈴木宗太, 八尾寛
Nov, 2005

東北大学大学院生命科学研究科研究奨励賞, 海馬苔状線維終末からの活動依存的な脳由来神経栄養因子(BDNF)開口分泌メカニズムの解析, 東北大学大学院生命科学研究科

Papers

Expanding the Toolbox of Upconversion Nanoparticles for In Vivo Optogenetics and Neuromodulation.

All AH, Zeng X, Teh DBL, Yi Z, Prasad A, Ishizuka T, Thakor N, Hiromu Y, Liu X

Advanced materials (Deerfield Beach, Fla.), 31(41) e1803474, Oct, 2019 Peer-reviewed
Driving Neurogenesis in Neural Stem Cells with High Sensitivity Optogenetics.

Teh DBL, Prasad A, Jiang W, Zhang N, Wu Y, Yang H, Han S, Yi Z, Yeo Y, Ishizuka T …

Neuromolecular medicine, Oct, 2019 Peer-reviewed
Optogenetic study of the response interaction among multi-afferent inputs in the barrel cortex of rats.

Liu Y, Ohshiro T, Sakuragi S, Koizumi K, Mushiake H, Ishizuka T, Yawo H

Scientific reports, 9(1) 3917, Mar, 2019 Peer-reviewed
Targeted expression of step-function opsins in transgenic rats for optogenetic studies

Hiroyuki Igarashi, Keiko Ikeda, Hiroshi Onimaru, Ryosuke Kaneko, Kyo Koizumi, Kaoru Beppu, Kayo Nishizawa, Yukari Takahashi, Fusao Kato, Ko Matsui …

Scientific Reports, 8(1) 5435, Dec 1, 2018 Peer-reviewed
Red-Tuning of Channelrhodopsin Spectrum Using Long-Conjugated Retinal Analogues.

Shen YC, Sasaki T, Matsuyama T, Yamashita T, Shichida Y, Okitsu T, Yamano Y, Wada A, Ishizuka T, Yawo H …

Biochemistry, 57(38) 5544-5556, Sep, 2018 Peer-reviewed
Organelle Optogenetics: Direct Manipulation of Intracellular Ca²⁺ Dynamics by Light.

Asano T, Igarashi H, Ishizuka T, Yawo H

Frontiers in neuroscience, 12 561-561, Aug, 2018 Peer-reviewed
Functional emergence of a column-like architecture in layer 5 of mouse somatosensory cortex in vivo.

Koizumi K, Inoue M, Chowdhury S, Bito H, Yamanaka A, Ishizuka T, Yawo H

The journal of physiological sciences : JPS, May, 2018 Peer-reviewed
Blockade of the K ATP channel Kir6.2 by memantine represents a novel mechanism relevant to Alzheimer's disease therapy

S. Moriguchi, T. Ishizuka, Y. Yabuki, N. Shioda, Y. Sasaki, H. Tagashira, H. Yawo, J. Z. Yeh, H. Sakagami, T. Narahashi …

Molecular Psychiatry, 23(2) 211-221, Feb 1, 2018 Peer-reviewed
Functional characterization of sodium-pumping rhodopsins with different pumping properties

Satoshi P. Tsunoda, Matthias Prigge, Rei Abe-Yoshizumi, Keiichi Inoue, Yuko Kozaki, Toru Ishizuka, Hiromu Yawo, Ofer Yizhar, Hideki Kandori

PLOS ONE, 12(7) e0179232, Jul, 2017 Peer-reviewed
Alternative Formation of Red-Shifted Channelrhodopsins: Noncovalent Incorporation with Retinal-Based Enamine-Type Schiff Bases and Mutated Channelopsin

Takashi Okitsu, Take Matsuyama, Takahiro Yamashita, Toru Ishizuka, Hiromu Yawo, Yasushi Imamoto, Yoshinori Shichida, Akimori Wada

CHEMICAL & PHARMACEUTICAL BULLETIN, 65(4) 356-358, Apr, 2017 Peer-reviewed
Kinetic characteristics of chimeric channelrhodopsins implicate the molecular identity involved in desensitization

Zamani A, Sakuragi S, Ishizuka T, Yawo H

Biophysics and Physicobiology, 14 13-22, Jan 24, 2017 Peer-reviewed
A Chimera Na+ -Pump Rhodopsin as an Effective Optogenetic Silencer

Mohammad Razuanul Hogue, Toru Ishizuka, Keiichi Inoue, Rei Abe-Yoshizumi, Hiroyuki Igarashi, Takaaki Mishima, Hideki Kandori, Hiromu Yawo

PLOS ONE, 11(11) e0166820, Nov, 2016 Peer-reviewed
Position- and quantity-dependent responses in zebrafish turning behavior

Keiko Umeda, Toru Ishizuka, Hiromu Yawo, Wataru Shoji

SCIENTIFIC REPORTS, 6 27888, Jun, 2016 Peer-reviewed
A Novel Reporter Rat Strain That Conditionally Expresses the Bright Red Fluorescent Protein tdTomato

Hiroyuki Igarashi, Kyo Koizumi, Ryosuke Kaneko, Keiko Ikeda, Ryo Egawa, Yuchio Yanagawa, Shin-ichi Muramatsu, Hiroshi Onimaru, Toru Ishizuka, Hiromu Yawo

PLOS ONE, 11(5) e0155687, May, 2016 Peer-reviewed
The regulatory mechanism of ion permeation through a channelrhodopsin derived from Mesostigma viride (MvChR1)

Shota Watanabe, Toru Ishizuka, Shoko Hososhima, Alemeh Zamani, Mohammad Razuanul Hoque, Hiromu Yawo

PHOTOCHEMICAL & PHOTOBIOLOGICAL SCIENCES, 15(3) 365-374, 2016 Peer-reviewed
Membrane depolarization regulates intracellular RANKL transport in non-excitable osteoblasts

Takuya Notomi, Miyuki Kuno, Akiko Hiyama, Yoichi Ezura, Masashi Honma, Toru Ishizuka, Kiyoshi Ohura, Hiromu Yawo, Masaki Noda

BONE, 81 306-314, Dec, 2015 Peer-reviewed
Near-infrared (NIR) up-conversion optogenetics

Shoko Hososhima, Hideya Yuasa, Toru Ishizuka, Mohammad Razuanul Hoque, Takayuki Yamashita, Akihiro Yamanaka, Eriko Sugano, Hiroshi Tomita, Hiromu Yawo

SCIENTIFIC REPORTS, 5 16533, Nov, 2015 Peer-reviewed
A Phox2b BAC Transgenic Rat Line Useful for Understanding Respiratory Rhythm Generator Neural Circuitry

Keiko Ikeda, Masanori Takahashi, Shigeru Sato, Hiroyuki Igarashi, Toru Ishizuka, Hiromu Yawo, Satoru Arata, E. Michelle Southard-Smith, Kiyoshi Kawakami, Hiroshi Onimaru

PLOS ONE, 10(7) e0132475, Jul, 2015 Peer-reviewed
Chimeras of Channelrhodopsin-1 and-2 from Chlamydomonas reinhardtii Exhibit Distinctive Light-induced Structural Changes from Channelrhodopsin-2

Asumi Inaguma, Hisao Tsukamoto, Hideaki E. Kato, Tetsunari Kimura, Toru Ishizuka, Satomi Oishi, Hiromu Yawo, Osamu Nureki, Yuji Furutani

JOURNAL OF BIOLOGICAL CHEMISTRY, 290(18) 11623-11634, May, 2015 Peer-reviewed
Structural basis for Na+ transport mechanism by a light-driven Na+ pump

Hideaki E. Kato, Keiichi Inoue, Rei Abe-Yoshizumi, Yoshitaka Kato, Hikaru Ono, Masae Konno, Shoko Hososhima, Toru Ishizuka, Mohammad Razuanul Hoque, Hirofumi Kunitomo …

NATURE, 521(7550) 48-U347, May, 2015 Peer-reviewed

Misc.

Myogenic maturation by optical-training in cultured skeletal muscle cells

Toshifumi Asano, Toru Ishizuka, Hiromu Yawo

Methods in Molecular Biology, 1668 135-145, 2017
Engineering biological systems for light

Ishizuka T, Egawa R, Umeda K, Shoji W, Yawo H

SEIBUTSU BUTSURI, 55(6) 311-316, Nov 25, 2015
Optogenetic manipulation of neural and non-neural functions

Hiromu Yawo, Toshifumi Asano, Seiichiro Sakai, Toru Ishizuka

DEVELOPMENT GROWTH & DIFFERENTIATION, 55(4) 474-490, May, 2013
Channelrhodopsins—Their potential in gene therapy for neurological disorders

Ji ZG, Ishizuka T, Yawo H

Neurosci Res, 75(1) 6-12, Jan, 2013
Signal delivery to the brain using optogenetics

T. Honjoh, Z-G. Ji, Y. Yokoyama, A. Sumiyoshi, T. Ishizuka, R. Kawakshima, H. Yawo

Reports on The 437th Topical Meeting of The Laser Society of Japan - Neurophotonics, 15-19, Dec, 2012
Parallel-patterned optogenetic system

Hiromu Yawo, Seiichiro Sakai, Kenichi Ueno, Toru Ishizuka

Experimental Medicine, 30(16) 2584-2585, Oct 1, 2012
Molecular dynamics of photo-electrical transducing proteins, channelrhodopsins

Hiromu Yawo, Saki Tanimoto, Toru Ishizuka, Tetsuo Takahashi

SEIBUTSU BUTSURI, 52(5) 226-229, Sep 25, 2012
Controlling Neuronal Circuits with Light

Toru ISHIZUKA, Hiromu YAWO

The Review of Laser Engineering, 40(4) 254-258, Apr 19, 2012
光信号を電気情報に換えるタンパク質チャネルロドプシン −オプトジェネティクスへの招待−

Yuka Sugiyama, Hongxia Wan, Toru Ishizuka, Hiromu Yawo

Chemistry Today, 459(459) 30-36, Jun 1, 2009
網膜神経細胞光刺激技術の開発−基礎科学研究および医療・福祉への応用

八尾寛, 石塚徹, 王紅霞

Reserch papers of the Suzuken memorial fundation, 26 132-140, Feb, 2009
Presynaptic mechanisms of learning and memory

Hiromu Yawo, Toru Ishizuka

Brain and Nerve, 60(7) 725-736, Jul, 2008
Photostimulation of genetically engineered neurons expressing channelrhodopsin-2, a light-gated cation channel.

Toru Ishizuka, Hiromu Yawo

SEIBUTSU BUTSURI, 48(3) 180-184, May 25, 2008
pH感受性蛍光タンパク質フルオリンを用いたエキソサイトーシスの光学計測

石塚徹, 八尾寛

化学と生物, 43(4) 245-250, Apr 1, 2005
Synaphins/complexins, cytosolic proteins associated for neurotransmitter release

Ishizuka T, Abe T

Tanpakushitsu Kakusan Koso, 45(3 Suppl) 449-455, Feb, 2000

Books and Other Publications

Encyclopedia of Photobiology

日本光生物学協会, 光と生命の事典, 編集委員会 (Role: Editor, 73 チャネルロドプシン，150頁〜151頁)

朝倉書店, Feb 25, 2016 (ISBN: 9784254171617)
Optogenetics: Light-Sensing Proteins and Their Applications

Ji Z-G, Ishizuka T, Yawo H (Role: Joint editor, Chapter 21, Strategies to Probe Mechanoreception: From Mechanical to Optogenetic Approaches, pp305-314)

Springer Japan, 2015 (ISBN: 9784431555155)
Muscle Cells: Development, Disorders and Regeneration (Ed, Benigno Pezzo)

Toshifumi Asano, Toru Ishizuka, Hiromu Yawo (Role: Joint author, Chapter 5 - Muscular Optogenetics: Controlling Muscle Functions with Light (pp. 127-136))

Nova Science Publishers, Inc., Jan, 2013 (ISBN: 9781624172335)

Presentations

198

ラットバレル野におけるマルチ・ウィスカ入力間相互作用の光遺伝学的解析

劉越人, 大城朝一, 櫻木繁雄, 虫明元, 石塚徹, 八尾寛

第50回東北整理談話会, Oct 13, 2018
Development of red-shifted channelrhodopsin variants using long-conjugated retinal analogues

Shen Y-C, Sasaki T, Matsuyama T, Yamashita T, Shichida Y, Okitsu T, Yamano Y, Wada A, Ishizuka T, Yawo H, Imamoto Y

18th International Conference on Retinal Proteins, Sep 24, 2018
Impact and mechanism of phosphate binding to a light-driven anion transporter SyHR

Kojima K, Nakama M, Kurihara M, Shibukawa A, Yoshizawa S, Ishizuka T, Yawo H, Sudo Y

18th International Conference on Retinal Proteins, Sep 24, 2018
レチナールアナログを使用した深赤色光受容チャネルロドプシンの開発

沈宜中, 佐々木寿算, 山下高廣, 七田芳則, 沖津貴志, 山野由美子, 和田昭盛, 石塚徹, 八尾寛, 今元泰

2017年度生命科学系学会合同年次大会 (ConBio2017), Dec 6, 2017
ミトコンドリア機能の光操作

横山超一, 坂田一生, 五十嵐敬幸, 石塚徹, 八尾寛

第49回東北生理談話会, Oct 14, 2017
Functional control of clonal microglia by photo-activated channelrhodopsin-green receiver (ChRGR)

Jul 20, 2017
神経細胞における細胞内Ca⁺ダイナミクスの光操作

杉原嘉一, 五十嵐敬幸, 櫻木繁雄, 石塚徹, 八尾寛

第94回日本生理学会大会, Mar 28, 2017
アップコンバージョン・ナノ粒子を用いた近赤外光によるニューロンネットワークの光操作

八尾寛, 細島頌子, 湯浅英哉, 山下貴之, 山中章弘, 石塚徹

第94回日本生理学会大会, Mar 28, 2017
オルガネラ・オプトジェネティクス−細胞内Ca²⁺ダイナミクスの光操作

五十嵐敬幸, 吉川彩香, 浅野豪文, 今野歩, 櫻木繁雄, 石塚徹, 平井宏和, 八尾寛

第94回日本生理学会大会, Mar 28, 2017
Upconversion-rhodopsin hybrid system for near-infared optogenetics

Hososhima S, Yuasa H, Ishizuka T, Yawo H

17th International Conference on Retinal Proteins, Oct 2, 2016
Optogenetic silencing of neural activity using a chimeric light-driven Na⁺-transporter rhodopsin

Hoque MR, Ishizuka T, Yawo H

第39回日本神経科学大会 (Neuroscience 2016), Jul 20, 2016
発達期初期ニワトリ胚毛様体神経節におけるカスパーゼシステムと軸索投射パターン

加藤秀理, 石塚徹, 八尾寛

第39回日本神経科学大会 (Neuroscience 2016), Jul 20, 2016
近赤外光によるアップコンバージョン・オプトジェネティクス

八尾寛, 細島頌子, Hoque MR, 湯浅英哉, 山下貴之, 山中章弘, 石塚徹

第39回日本神経科学大会 (Neuroscience 2016), Jul 20, 2016
Near-infrared (NIR) controlled optogenetics in zebrafish larva

49th Annual Meeting of the Japanese Society of Developmental Biologists, May 31, 2016
近赤外オプトジェネティクスを用いたニューロンの制御

細島頌子, 湯浅英哉, 菅野江里子, 冨田浩史, 石塚徹, 八尾寛

第93回日本生理学会大会, Mar 22, 2016
軸索はいかにして標的を奪い合うのか？：発達期軸索再編の定量コネクトミクス解析

江川遼, 石塚徹, 八尾寛

2015年度包括型脳科学研究推進支援ネットワーク冬のシンポジウム, Dec 17, 2015
新規トランスジェニックラット3系統の開発 -tdTomatoレポーターラット, Flameラット, ChR(SFO)発現ラット-

五十嵐敬幸, 石塚徹, 八尾寛

2015年度包括型脳科学研究推進支援ネットワーク冬のシンポジウム, Dec 17, 2015
Extraction of the cytoplasm from single cell using planar patch clamp arrangement

Uno H, Wang Z-H, Ishigaki S, Ishizuka T, Takamura Y, Urisu T

The International Chemical Congress of Pacific Basin Societies 2015 (Pacifichem 2015), Dec 15, 2015
Optogenetic silencing of neuronal activity using a light-driven sodium ion pump in marine bacteria

Ishizuka T, Hososhima S, Hoque MR, Yoshida K, Inoue K, Kandori H, Yawo H

The International Chemical Congress of Pacific Basin Societies 2015 (Pacifichem 2015), Dec 15, 2015
Extraction of cytoplasm for suitably and quantitatively analyzing mRNA of a single cell

Uno H, Wang Z-H, Ishigaki S, Ukita Y, Ishizuka T, Takayama Y, Urisu T

9th International Symposium on Nanomedicine (ISNM2015), Dec 10, 2015

Professional Memberships

Industrial Property Rights

特許第5544659号改変された光受容体チャネル型ロドプシンタンパク質

八尾寛, 石塚徹