2016年7月
Accelerated decline of physical strength in peroxiredoxin-3 knockout mice
EXPERIMENTAL BIOLOGY AND MEDICINE
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- 巻
- 241
- 号
- 13
- 開始ページ
- 1395
- 終了ページ
- 1400
- 記述言語
- 英語
- 掲載種別
- 研究論文(学術雑誌)
- DOI
- 10.1177/1535370216642039
- 出版者・発行元
- SAGE PUBLICATIONS LTD
As a member of peroxiredoxin family, peroxiredoxin-3 plays a major role in the control of mitochondrial level of reactive oxygen species. During the breeding of experimental mice, we noticed that the peroxiredoxin-3 knockout mice were listless with aging. In the present study, we compared the swimming exercise performance and oxidative status between peroxiredoxin-3 knockout mice (n = 15) and wild-type littermates (n = 15). At the age of 10 months, the physical strength of peroxiredoxin-3 knockout mice was much lower than the wild-type littermates. Increased oxidative damage and decreased mitochondrial DNA copy number of the animal skeletal muscles were observed in peroxiredoxin-3 knockout mice as compared to that in the wild-type littermates. In addition, we found increased apoptotic cells in the brains of peroxiredoxin-3 knockout mice. Our results suggest that the deficiency of peroxiredoxin-3 induces accelerated oxidative stress and mitochondrial impairment, resulting in the decrease of energy supply and cellular activities. Peroxiredoxin-3 might be involved in the inhibition of aging process.
- リンク情報
- ID情報
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- DOI : 10.1177/1535370216642039
- ISSN : 1535-3702
- eISSN : 1535-3699
- PubMed ID : 27037278
- Web of Science ID : WOS:000379791400004