2007年3月
Etiology of severe sensorineural hearing loss in children: Independent impact of congenital cytomegalovirus infection and GJB2 mutations
JOURNAL OF INFECTIOUS DISEASES
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- 巻
- 195
- 号
- 6
- 開始ページ
- 782
- 終了ページ
- 788
- 記述言語
- 英語
- 掲載種別
- 研究論文(学術雑誌)
- DOI
- 10.1086/511981
- 出版者・発行元
- UNIV CHICAGO PRESS
Background. Sensorineural hearing loss (SNHL) is the most common congenital disease. Longitudinal studies of infants with congenital cytomegalovirus (CMV) infection have demonstrated an association between CMV and SNHL. However, because of the lack of suitable neonatally collected specimens, the proportion of CMV-associated SNHL has not been defined, nor has the relationship between CMV and the major genetic causes of SNHL, such as mutations in the GJB2 gene.
Methods. Sixty-seven children with severe SNHL were analyzed for CMV and human herpesvirus 6 (HHV6) infections and for GJB2 mutations. DNA specimens were prepared from dried umbilical cords, which are available for everyone born in Japan. Four children with typical symptomatic infection at birth served as positive control subjects.
Results. Congenital CMV infection and GJB2 mutations were identified in 15% and 24% of the patients, respectively. HHV-6 was not detected. All children with CMV-associated cases developed SNHL before they were 2 years old. Most children with CMV-associated SNHL had no obvious clinical abnormality at birth, and their viral loads were lower than those of symptomatic children.
Conclusions. Congenital CMV infection is an important cause of severe SNHL, and it has an incidence comparable to that of GJB2-associated SNHL.
Methods. Sixty-seven children with severe SNHL were analyzed for CMV and human herpesvirus 6 (HHV6) infections and for GJB2 mutations. DNA specimens were prepared from dried umbilical cords, which are available for everyone born in Japan. Four children with typical symptomatic infection at birth served as positive control subjects.
Results. Congenital CMV infection and GJB2 mutations were identified in 15% and 24% of the patients, respectively. HHV-6 was not detected. All children with CMV-associated cases developed SNHL before they were 2 years old. Most children with CMV-associated SNHL had no obvious clinical abnormality at birth, and their viral loads were lower than those of symptomatic children.
Conclusions. Congenital CMV infection is an important cause of severe SNHL, and it has an incidence comparable to that of GJB2-associated SNHL.
- リンク情報
- ID情報
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- DOI : 10.1086/511981
- ISSN : 0022-1899
- PubMed ID : 17299707
- Web of Science ID : WOS:000244243000005