2013年12月
SQSTM1 Is a Pathogenic Target of 5q Copy Number Gains in Kidney Cancer
CANCER CELL
- 巻
- 24
- 号
- 6
- 開始ページ
- 738
- 終了ページ
- 750
- 記述言語
- 英語
- 掲載種別
- 研究論文(学術雑誌)
- DOI
- 10.1016/j.ccr.2013.10.025
- 出版者・発行元
- CELL PRESS
Clear cell renal cell carcinoma (ccRCC) is the most common form of kidney cancer and is often linked to loss of chromosome 3p, which harbors the VHL tumor suppressor gene, loss of chromosome 14q, which includes HIF1A, and gain of chromosome 5q. The relevant target(s) on chromosome 5q is not known. Here, we show that 5q amplification leads to overexpression of the SQSTM1 oncogene in ccRCC lines and tumors. Overexpression of SQSTM1 in ccRCC lines promoted resistance to redox stress and increased soft agar growth, while downregulation of SQSTM1 decreased resistance to redox stress, impaired cellular fitness, and decreased tumor formation. Therefore, the selection pressure to amplify 5q in ccRCC is driven, at least partly, by SQSTM1.
- リンク情報
- ID情報
-
- DOI : 10.1016/j.ccr.2013.10.025
- ISSN : 1535-6108
- eISSN : 1878-3686
- Web of Science ID : WOS:000328443200008